TcYC6_0011810

Eukaryotic translation initiation factor 4E-3
Trypanosoma cruzi Y C6 OG6: OG6_134811 OG7: OG7_0002303 214 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 214 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0081270 ⚠
aspartate aminotransferase, mitochondrial, pu
— OG7
TcYC6_0054200 ⚠
6-phosphogluconolactonase, putative
— OG7
TcYC6_0108610 ⚠
U-box domain protein, putative
— OG7
TcYC6_0118110 ⚠
TAP42-like family, putative
— OG7
TcYC6_0115350 ⚠
Activator of Hsp90 ATPase, N-terminal/Activat
— OG7
TcYC6_0016600 ⚠
Mitochondrial Editosome-like Complex TUTase
— OG7
TcYC6_0079840 ⚠
eukaryotic translation initiation factor 6 (e
— OG7
TcYC6_0022140 ⚠
RNA polymerase II, putative
— OG7
TcYC6_0009920 ⚠
CAMK/CAMKL pseudokinase, putative
— OG7
TcYC6_0100460 ⚠
CAMK/CAMKL family protein kinase, putative
— OG7
TcYC6_0115110 ⚠
pyruvate kinase 2, putative
— OG7
TcYC6_0009840 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0010170 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0007710 ⚠
Biotin--acetyl-CoA-carboxylase ligase, putati
— OG7
TcYC6_0066530 ⚠
dihydroorotase, putative
— OG7
TcYC6_0110350 ⚠
5'-AMP-activated protein kinase catalytic sub
— OG7
TcYC6_0070940 ⚠
Co-chaperone protein P23
— OG7
TcYC6_0070400 ⚠
Protein of unknown function (DUF2009), putati
— OG7
TcYC6_0119710 ⚠
2,4-dihydroxyhept-2-ene-1,7-dioic acid aldola
— OG7
TcYC6_0012100 ⚠
elongation factor G2-like protein, putative
— OG7
TcYC6_0063070 ⚠
isocitrate dehydrogenase [NADP], mitochondria
— OG7
TcYC6_0112660 ⚠
CS domain containing protein, putative
— OG7
TcYC6_0078640 ⚠
CAMK/CAMKL family protein kinase, putative
— OG7
TcYC6_0093270 ⚠
calcium/calmodulin-dependent protein kinase,
— OG7
TcYC6_0074780 ⚠
isocitrate dehydrogenase, putative
— OG7
TcYC6_0142880 ⚠
retrotransposon hot spot (RHS) protein, putat
— OG7
TcYC6_0012450 ⚠
Small Surface Antigen
— OG7
TcYC6_0063100 ⚠
putative protein transport protein SEC23
— OG7
TcYC6_0092200 ⚠
R3H domain containing protein, putative
— OG7
TcYC6_0012390 ⚠
tRNA threonylcarbamoyl adenosine modification
— OG7
TcYC6_0042220 ⚠
Present in the outer mitochondrial membrane p
— OG7
TcYC6_0107860 ⚠
nuclear transcription factor, putative
— OG7
TcYC6_0095910 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0085920 ⚠
deoxyhypusine hydroxylase, putative
— OG7
TcYC6_0108130 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0043360 ⚠
PUB domain containing protein, putative
— OG7
TcYC6_0055560 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0093620 ⚠
small nuclear ribonucleoprotein, putative
— OG7
TcYC6_0110890 ⚠
Flagellum attachment zone protein 19, putativ
— OG7
TcYC6_0111760 ⚠
quinone oxidoreductase, putative
— OG7
TcYC6_0121770 ⚠
protein transport protein SEC23
— OG7
TcYC6_0079830 ⚠
SNF1-related protein kinase, putative
— OG7
TcYC6_0116190 ⚠
UTP-glucose-1-phosphate uridylyltransferase 2
— OG7
TcYC6_0108170 ⚠
UBX domain-containing protein
— OG7
TcYC6_0088930 ⚠
pyroglutamyl-peptidase I, putative
— OG7
TcYC6_0000840 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0142810 ⚠
retrotransposon hot spot (RHS) protein, putat
— OG7
TcYC6_0080140 ⚠
Elongation factor G1, mitochondrial, putative
— OG7
TcYC6_0100560 ⚠
Domain of unknown function (DUF3437), putativ
— OG7
TcYC6_0072920 ⚠
phenylalanyl-tRNA synthetase (beta subunit),
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.