TcYC6_0115110

pyruvate kinase 2, putative
Trypanosoma cruzi Y C6 OG6: OG6_100258 OG7: OG7_0002165 207 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 207 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0044260 ⚠
acidocalcisomal pyrophosphatase, putative
— Both
TcYC6_0019440
Bifunctional NAD(P)H-hydrate repair enzyme
— Both
TcYC6_0111400 ⚠
inorganic pyrophosphatase, putative
— Both
TcYC6_0098250 ⚠
glyceraldehyde 3-phosphate dehydrogenase, put
— Both
TcYC6_0115010
N-myristoyl transferase, putative
— Both
TcYC6_0074380 ⚠
UBA/TS-N domain containing protein, putative
— Both
TcYC6_0092460
SEP domain containing protein, putative
— Both
TcYC6_0030300
alanine racemase, putative
— Both
TcYC6_0045150
electron-transfer-flavoprotein, alpha polypep
— Both
TcYC6_0045720 ⚠
protein phosphatase 2C, putative
— OG6
TcYC6_0095140 ⚠
phosphatase 2C, putative
— OG6
TcYC6_0045140
Component of motile flagella 15
— Both
TcYC6_0051940 ⚠
hypothetical protein, conserved
— Both
TcYC6_0084720
rotamase, putative
— OG6
TcYC6_0012390
tRNA threonylcarbamoyl adenosine modification
— Both
TcYC6_0110890
Flagellum attachment zone protein 19, putativ
— Both
TcYC6_0005350 ⚠
aminoacylase, putative
— Both
TcYC6_0005340 ⚠
amidohydrolase, putative
— Both
TcYC6_0005360 ⚠
amidohydrolase, putative
— Both
TcYC6_0109610 ⚠
carnitine/choline acetyltransferase, putative
— Both
TcYC6_0091050
phosphomannomutase-like protein, putative
— Both
TcYC6_0028500 ⚠
cAMP specific phosphodiesterase, putative
— Both
TcYC6_0084380 ⚠
fatty acyl CoA synthetase 2, putative
— Both
TcYC6_0047040 ⚠
NADH-dependent fumarate reductase
— Both
TcYC6_0043810 ⚠
metallo-peptidase, Clan MF, Family M17
— Both
TcYC6_0109070
guanine deaminase, putative
— Both
TcYC6_0017040 ⚠
cysteine peptidase, Clan CA, family C2, putat
— OG6
TcYC6_0098230 ⚠
glyceraldehyde 3-phosphate dehydrogenase, put
— Both
TcYC6_0084390 ⚠
fatty acyl CoA synthetase 2, putative
— Both
TcYC6_0126720 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— Both
TcYC6_0017070 ⚠
putative calpain-like cysteine peptidase
— OG6
TcYC6_0047480 ⚠
NADH-dependent fumarate reductase
— Both
TcYC6_0102650
adenylosuccinate synthetase, putative
— Both
TcYC6_0028510 ⚠
cAMP specific phosphodiesterase, putative
— Both
TcYC6_0045790
dihydrofolate reductase-thymidylate synthase
— Both
TcYC6_0098240 ⚠
glyceraldehyde 3-phosphate dehydrogenase, put
— Both
TcYC6_0024850 ⚠
cysteine peptidase, Clan CA, family C2, putat
— OG6
TcYC6_0047490 ⚠
NADH-dependent fumarate reductase, putative
— Both
TcYC6_0098890
S-adenosylmethionine synthetase, putative
— Both
TcYC6_0127290 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— Both
TcYC6_0026330 ⚠
calpain-like cysteine peptidase
— OG6
TcYC6_0125230
nicotinate phosphoribosyltransferase, putativ
— Both
TcYC6_0004020 ⚠
fatty acyl CoA synthetase, putative
— Both
TcYC6_0084410 ⚠
fatty acyl CoA syntetase 1
— Both
TcYC6_0026340 ⚠
hypothetical protein
— OG6
TcYC6_0029360 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— Both
TcYC6_0084400 ⚠
fatty acyl CoA synthetase 2, putative
— Both
TcYC6_0047150 ⚠
glyceraldehyde 3-phosphate dehydrogenase, cyt
— Both
TcYC6_0071270 ⚠
glyceraldehyde-3-phosphate dehydrogenase, put
— Both
TcYC6_0028450 ⚠
glutaminyl-tRNA synthetase, putative
— Both
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.