TcYC6_0032520

GDP-mannose pyrophosphorylase
Trypanosoma cruzi Y C6 OG6: OG6_100460 OG7: OG7_0001668 213 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 213 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0128180 ⚠
glutamine synthetase, putative
— Both
TcYC6_0044260 ⚠
acidocalcisomal pyrophosphatase, putative
— Both
TcYC6_0111400 ⚠
inorganic pyrophosphatase, putative
— Both
TcYC6_0127080
inositol-3-phosphate synthase, putative
— Both
TcYC6_0046330 ⚠
glutamine synthetase, putative
— Both
TcYC6_0027170 ⚠
hypothetical protein
— Both
TcYC6_0123380
hypothetical protein, conserved
— Both
TcYC6_0029650 ⚠
ABC transporter, putative
— OG7
TcYC6_0024170 ⚠
ABC transporter, putative
— OG7
TcYC6_0002740 ⚠
ABC transporter, putative
— OG7
TcYC6_0004090 ⚠
ABC transporter, putative
— OG7
TcYC6_0124530 ⚠
ATP-binding cassette sub-family F member 1, p
— OG7
TcYC6_0076500 ⚠
GTP-binding protein, putative
— OG7
TcYC6_0050280 ⚠
hypothetical protein
— OG7
TcYC6_0100340 ⚠
6-phosphofructo-2-kinase/fructose-2,6-biphosp
— OG7
TcYC6_0111530 ⚠
6-phosphofructo-2-kinase 1
— OG7
TcYC6_0080710 ⚠
6-phosphofructo-2-kinase/fructose-2,6-bisphos
— OG7
TcYC6_0049700 ⚠
hypothetical protein
— OG7
TcYC6_0043870 ⚠
cytochrome b5
— OG7
TcYC6_0049170 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0058570 ⚠
cytochrome b5-like Heme/Steroid binding domai
— OG7
TcYC6_0109080 ⚠
cytochrome b5, putative
— OG7
TcYC6_0040620 ⚠
cytochrome b5, putative
— OG7
TcYC6_0090570 ⚠
cleavage and polyadenylation specificity fact
— OG7
TcYC6_0024770 ⚠
mitochondrial exoribonuclease DSS-1, putative
— OG7
TcYC6_0044850 ⚠
exosome complex exonuclease RRP44p-like
— OG7
TcYC6_0072780 ⚠
aminopeptidase, putative,metallo-peptidase, C
— OG7
TcYC6_0113630 ⚠
ABC transport system ATP-binding protein, put
— Both
TcYC6_0087910
hypothetical protein, conserved
— Both
TcYC6_0083670
tubulin folding cofactor D, putative
— Both
TcYC6_0095370
hypothetical protein, conserved
— Both
TcYC6_0062940
hypothetical protein, conserved
— Both
TcYC6_0122980
isoleucyl-tRNA synthetase, putative
— Both
TcYC6_0027240 ⚠
hypothetical protein
— Both
TcYC6_0019430 ⚠
tyrosyl-tRNA synthetase, putative
— Both
TcYC6_0063050
hypothetical protein, conserved
— Both
TcYC6_0007460
hypothetical protein, conserved
— Both
TcYC6_0004940 ⚠
mitochondrial DNA polymerase beta, putative
— Both
TcYC6_0066100 ⚠
ubiquitin-activating enzyme
— Both
TcYC6_0107880
Facilitates chromatin transcription complex s
— Both
TcYC6_0080720
PUB domain containing protein, putative
— Both
TcYC6_0124540 ⚠
heat shock protein 85, putative
— +2 more Both
TcYC6_0065870
hypothetical protein, conserved
— Both
TcYC6_0088920
Zeta toxin, putative
— Both
TcYC6_0047950 ⚠
hypothetical protein, conserved
— Both
TcYC6_0005960 ⚠
Adaptor protein complex AP-3 subunit beta-3
— OG7
TcYC6_0005400
tRNA (Uracil-5-)-methyltransferase, putative
— Both
TcYC6_0062970
hypothetical protein
— Both
TcYC6_0031670
pteridine reductase
— Both
TcYC6_0022740
methionyl-tRNA synthetase, putative
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.