TcYC6_0123380

hypothetical protein, conserved

Trypanosoma cruzi Y C6 OG6: OG6_110710 OG7: OG7_0006349 148 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 148 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcYC6_0111530 ⚠ 6-phosphofructo-2-kinase 1	—	OG6 TCSYLVIO_004468 ↔ TCSYLVIO_004736 OG6 LdBPK_030790.1 ↔ LdBPK_364440.1 OG7 TCSYLVIO_002376 ↔ TCSYLVIO_004736 OG7 TCSYLVIO_004468 ↔ TCSYLVIO_004736	Both
TcYC6_0100340 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-biphosp	—	OG6 TCSYLVIO_004468 ↔ TCSYLVIO_004736 OG6 LdBPK_030790.1 ↔ LdBPK_364440.1 OG7 TCSYLVIO_002376 ↔ TCSYLVIO_004736 OG7 TCSYLVIO_004468 ↔ TCSYLVIO_004736	Both
TcYC6_0069000 ⚠ Leucine carboxyl methyltransferase/Cupin-like	—	OG6 LdBPK_352990.1 ↔ LdBPK_364440.1 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005852 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005852	Both
TcYC6_0072920 phenylalanyl-tRNA synthetase (beta subunit),	—	OG6 LdBPK_191010.1 ↔ LdBPK_364440.1 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005548 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005548	Both
TcYC6_0072780 ⚠ aminopeptidase, putative,metallo-peptidase, C	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_004736	OG7
TcYC6_0124540 ⚠ heat shock protein 85, putative	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_008621 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_009400 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_009151 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_008621 +2 more	Both
TcYC6_0047490 ⚠ NADH-dependent fumarate reductase, putative	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005116 +2 more	Both
TcYC6_0065870 hypothetical protein, conserved	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_010560	Both
TcYC6_0088920 Zeta toxin, putative	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_010958 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_010958	Both
TcYC6_0062940 hypothetical protein, conserved	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_008446 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_008446	Both
TcYC6_0116640 hypothetical protein, conserved	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006238 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006238	Both
TcYC6_0032520 GDP-mannose pyrophosphorylase	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_007603	Both
TcYC6_0115710 hypothetical protein, conserved	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006181 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006181	Both
TcYC6_0061260 ⚠ helicase, putative	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006977 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006977	Both
TcYC6_0015540 dihydrolipoamide branched chain transacylase,	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_009880 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_009880	Both
TcYC6_0061280 ⚠ helicase, putative	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006977 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006977	Both
TcYC6_0124550 ⚠ putative heat shock protein 85	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_008621 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_009400 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_009151 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_008621 +2 more	Both
TcYC6_0026330 ⚠ calpain-like cysteine peptidase	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_007342	OG6
TcYC6_0021740 2-oxoisovalerate dehydrogenase alpha subunit,	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_009339 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_009339	Both
TcYC6_0047190 hypothetical protein, conserved	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005125 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005125	Both
TcYC6_0061220 ⚠ helicase, putative	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006977 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006977	Both
TcYC6_0046920 vacuolar ATP synthase subunit d	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005104 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005104	Both
TcYC6_0026340 ⚠ hypothetical protein	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_007342	OG6
TcYC6_0116560 prolyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006246	Both
TcYC6_0017040 ⚠ cysteine peptidase, Clan CA, family C2, putat	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_007342	OG6
TcYC6_0031670 pteridine reductase	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_008848 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_008848	Both
TcYC6_0072130 ⚠ hypothetical protein	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005619 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005619	Both
TcYC6_0047040 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005116 +2 more	Both
TcYC6_0022120 ATP synthase F1 subunit gamma protein, putati	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_009375 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_009375	Both
TcYC6_0120590 ⚠ putative Leucine rich repeat	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006421 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006421	Both
TcYC6_0114860 Histone chaperone Rttp106-like, putative	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006113 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006113	Both
TcYC6_0108150 Hsc70-interacting protein, putative	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_010703 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_010703	Both
TcYC6_0120270 ⚠ putative Leucine rich repeat	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006421 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006421	Both
TcYC6_0015370 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004736 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004736 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004736	Both
TcYC6_0095250 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004736 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004736 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004736	Both
TcYC6_0022580 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004736 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004736 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004736	Both
TcYC6_0023910 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_004736 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_004736 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_004736	Both
TcYC6_0102190 N(2), N(2)-dimethylguanosine tRNA methyltrans	—	OG6 TCSYLVIO_002844 ↔ TCSYLVIO_004736 OG7 TCSYLVIO_002844 ↔ TCSYLVIO_004736	Both
TcYC6_0095370 hypothetical protein, conserved	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_004736 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_004736	Both
TcYC6_0083670 tubulin folding cofactor D, putative	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_004736 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_004736	Both
TcYC6_0080710 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-bisphos	—	OG7 TCSYLVIO_002376 ↔ TCSYLVIO_004736 OG7 TCSYLVIO_004468 ↔ TCSYLVIO_004736	OG7
TcYC6_0091190 ⚠ Histidine kinase-, DNA gyrase B-, and HSP90-l	—	OG7 TCSYLVIO_004736 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004736	OG7
TcYC6_0028200 ⚠ putative inositol/phosphatidylinositol phosph	—	OG7 TCSYLVIO_004736 ↔ TCSYLVIO_007569	OG7
TcYC6_0146170 ⚠ retrotransposon hot spot (RHS) protein, putat	—	OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006596 OG7 TCSYLVIO_000702 ↔ TCSYLVIO_004736	OG7
TcYC6_0104220 ⚠ hypothetical protein	—	OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006596 OG7 TCSYLVIO_000702 ↔ TCSYLVIO_004736	OG7
TcYC6_0084200 ⚠ ubiquitin activating enzyme, putative	—	OG7 TCSYLVIO_004736 ↔ TCSYLVIO_010542	OG7
TcYC6_0034830 ⚠ CMGC/DYRK protein kinase, putative	—	OG7 TCSYLVIO_004736 ↔ TCSYLVIO_009362	OG7
TcYC6_0068480 ⚠ ubiquitin hydrolase, putative	—	OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005374	OG7
TcYC6_0073500 ⚠ ubiquitin carboxyl-terminal hydrolase, putati	—	OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005374	OG7
TcYC6_0123030 ⚠ beta adaptin, putative	—	OG7 TCSYLVIO_004597 ↔ TCSYLVIO_004736	OG7

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