TcYC6_0091190

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative

Trypanosoma cruzi Y C6 OG6: OG6_146732 OG7: OG7_0002830 139 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 139 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcYC6_0072920 ⚠ phenylalanyl-tRNA synthetase (beta subunit),	—	OG7 TCSYLVIO_005548 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_240010.1	OG7
TcYC6_0068420 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
TcYC6_0031230 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
TcYC6_0121920 ⚠ poly(A)-specific ribonuclease PARN, putative	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
TcYC6_0110770 ⚠ aspartyl aminopeptidase, putative	—	OG7 LdBPK_240010.1 ↔ LdBPK_292470.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004406	OG7
TcYC6_0061240 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_240010.1	OG7
TcYC6_0061260 ⚠ helicase, putative	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_240010.1	OG7
TcYC6_0061280 ⚠ helicase, putative	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_240010.1	OG7
TcYC6_0083670 ⚠ tubulin folding cofactor D, putative	—	OG7 LdBPK_240010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_007262	OG7
TcYC6_0061220 ⚠ helicase, putative	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_240010.1	OG7
TcYC6_0017360 ⚠ putative developmentally regulated phosphopro	—	OG7 Tb927.1.1000 ↔ Tb927.11.4780 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007262	OG7
TcYC6_0080930 ⚠ pyruvate dehydrogenase (lipoamide) kinase, pu	—	OG7 Tb927.1.1000 ↔ Tb927.11.4780 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007262	OG7
TcYC6_0015370 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
TcYC6_0023910 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
TcYC6_0089430 ⚠ asparaginyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
TcYC6_0095250 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
TcYC6_0022580 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
TcYC6_0043160 ⚠ protein transport protein SEC31, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_001623	OG7
TcYC6_0088260 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007569	OG7
TcYC6_0063050 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010944	OG7
TcYC6_0043300 ⚠ beta-adaptin 1, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004597 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_007262	OG7
TcYC6_0007460 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009198 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009198	OG7
TcYC6_0013090 ⚠ oxidoreductase-like protein, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_002566	OG7
TcYC6_0070640 ⚠ synaptojanin (N-terminal domain), putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007569	OG7
TcYC6_0024530 ⚠ inositol 5-phosphatase 1	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007569	OG7
TcYC6_0142880 ⚠ retrotransposon hot spot (RHS) protein, putat	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006596 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_002801 OG7 TCSYLVIO_000702 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000702 ↔ TCSYLVIO_007262 +1 more	OG7
TcYC6_0113000 ⚠ FK506-binding protein (FKBP)-type peptidyl-pr	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005957	OG7
TcYC6_0066100 ⚠ ubiquitin-activating enzyme	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010542 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010542	OG7
TcYC6_0123030 ⚠ beta adaptin, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004597 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_007262	OG7
TcYC6_0073420 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005512 OG7 TCSYLVIO_005512 ↔ TCSYLVIO_007262	OG7
TcYC6_0099600 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006116	OG7
TcYC6_0113560 ⚠ macrophage infectivity potentiator, precursor	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005957	OG7
TcYC6_0107880 ⚠ Facilitates chromatin transcription complex s	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010728 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010728	OG7
TcYC6_0005960 ⚠ Adaptor protein complex AP-3 subunit beta-3	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004597 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_007262	OG7
TcYC6_0079620 ⚠ endonuclease/exonuclease/phosphatase, putativ	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007569	OG7
TcYC6_0062380 ⚠ threonyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007511 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007511	OG7
TcYC6_0111710 ⚠ arginine N-methyltransferase, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006901	OG7
TcYC6_0124540 ⚠ heat shock protein 85, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009400 +2 more	OG7
TcYC6_0065870 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010560	OG7
TcYC6_0088920 ⚠ Zeta toxin, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010958 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010958	OG7
TcYC6_0062940 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008446 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008446	OG7
TcYC6_0108590 ⚠ heat shock protein 90, putative	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009400 +2 more	OG7
TcYC6_0032520 ⚠ GDP-mannose pyrophosphorylase	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007603	OG7
TcYC6_0043840 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001673 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_001673	OG7
TcYC6_0015540 ⚠ dihydrolipoamide branched chain transacylase,	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009880 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009880	OG7
TcYC6_0127990 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_001826	OG7
TcYC6_0087960 ⚠ uracil phosphoribosyltransferase, putative	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003952	OG7
TcYC6_0045780 ⚠ protein arginine n-methyltransferase 7	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006901	OG7
TcYC6_0022120 ⚠ ATP synthase F1 subunit gamma protein, putati	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009375 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009375	OG7
TcYC6_0119330 ⚠ hypothetical protein, conserved	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006116	OG7

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