TcYC6_0116560

prolyl-tRNA synthetase, putative

Trypanosoma cruzi Y C6 OG6: OG6_100749 OG7: OG7_0002333 184 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 184 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TcYC6_0089430 ⚠ asparaginyl-tRNA synthetase, putative	—	OG6 LdBPK_181220.1 ↔ LdBPK_342110.1 OG6 LdBPK_181230.1 ↔ LdBPK_342110.1 OG7 LdBPK_181220.1 ↔ LdBPK_342110.1 OG7 LdBPK_181230.1 ↔ LdBPK_342110.1 +1 more	Both
TcYC6_0061240 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_120255.1 ↔ LdBPK_181220.1 OG6 LdBPK_120255.1 ↔ LdBPK_181230.1 OG6 Tb927.10.12890 ↔ Tb927.6.950 OG7 Tb927.10.12890 ↔ Tb927.6.950 +2 more	Both
TcYC6_0061260 ⚠ helicase, putative	—	OG6 LdBPK_120255.1 ↔ LdBPK_181220.1 OG6 LdBPK_120255.1 ↔ LdBPK_181230.1 OG6 Tb927.10.12890 ↔ Tb927.6.950 OG7 Tb927.10.12890 ↔ Tb927.6.950 +2 more	Both
TcYC6_0061280 ⚠ helicase, putative	—	OG6 LdBPK_120255.1 ↔ LdBPK_181220.1 OG6 LdBPK_120255.1 ↔ LdBPK_181230.1 OG6 Tb927.10.12890 ↔ Tb927.6.950 OG7 Tb927.10.12890 ↔ Tb927.6.950 +2 more	Both
TcYC6_0061220 ⚠ helicase, putative	—	OG6 LdBPK_120255.1 ↔ LdBPK_181220.1 OG6 LdBPK_120255.1 ↔ LdBPK_181230.1 OG6 Tb927.10.12890 ↔ Tb927.6.950 OG7 Tb927.10.12890 ↔ Tb927.6.950 +2 more	Both
TcYC6_0115710 hypothetical protein, conserved	—	OG6 LdBPK_180550.1 ↔ LdBPK_181230.1 OG6 TCSYLVIO_006181 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_006181 ↔ TCSYLVIO_006246 OG7 LdBPK_180550.1 ↔ LdBPK_181230.1	Both
TcYC6_0083670 tubulin folding cofactor D, putative	—	OG6 LdBPK_181220.1 ↔ LdBPK_242100.1 OG6 LdBPK_181230.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_242100.1 +2 more	Both
TcYC6_0021550 ⚠ hypothetical protein	—	OG7 LdBPK_181230.1 ↔ LdBPK_332020.1 OG7 TCSYLVIO_005619 ↔ TCSYLVIO_006246	OG7
TcYC6_0116640 hypothetical protein, conserved	—	OG6 TCSYLVIO_006238 ↔ TCSYLVIO_006246 OG6 LdBPK_181230.1 ↔ LdBPK_181300.1 OG7 LdBPK_181230.1 ↔ LdBPK_181300.1 OG7 TCSYLVIO_006238 ↔ TCSYLVIO_006246	Both
TcYC6_0072130 ⚠ hypothetical protein	—	OG6 TCSYLVIO_005619 ↔ TCSYLVIO_006246 OG6 LdBPK_181230.1 ↔ LdBPK_332020.1 OG7 LdBPK_181230.1 ↔ LdBPK_332020.1 OG7 TCSYLVIO_005619 ↔ TCSYLVIO_006246	Both
TcYC6_0093170 guide RNA associated protein, GAP2, putative	—	OG6 LdBPK_181230.1 ↔ LdBPK_220520.1 OG6 TCSYLVIO_001262 ↔ TCSYLVIO_006246 OG7 LdBPK_181230.1 ↔ LdBPK_220520.1 OG7 TCSYLVIO_001262 ↔ TCSYLVIO_006246	Both
TcYC6_0015370 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_342110.1 OG7 LdBPK_181230.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_006246	Both
TcYC6_0095250 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_342110.1 OG7 LdBPK_181230.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_006246	Both
TcYC6_0022580 ⚠ aspartyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_342110.1 OG7 LdBPK_181230.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_006246	Both
TcYC6_0023910 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_342110.1 OG7 LdBPK_181230.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_006246	Both
TcYC6_0097650 ⚠ replication factor C, subunit 2, putative	—	OG7 LdBPK_181220.1 ↔ LdBPK_241010.1 OG7 LdBPK_181230.1 ↔ LdBPK_241010.1	OG7
TcYC6_0121490 ⚠ replication factor C subunit 3, putative	—	OG7 LdBPK_181220.1 ↔ LdBPK_241010.1 OG7 LdBPK_181230.1 ↔ LdBPK_241010.1	OG7
TcYC6_0005570 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_181220.1 ↔ LdBPK_261200.1 OG7 LdBPK_181230.1 ↔ LdBPK_261200.1	OG7
TcYC6_0053860 ⚠ Outer row dynein-assembly protein 7	—	OG7 LdBPK_181220.1 ↔ LdBPK_261200.1 OG7 LdBPK_181230.1 ↔ LdBPK_261200.1	OG7
TcYC6_0123530 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_181230.1 ↔ LdBPK_321150.1	OG7
TcYC6_0096210 ⚠ small nuclear ribonucleoprotein Sm-E, putativ	—	OG7 LdBPK_181230.1 ↔ LdBPK_260010.1	OG7
TcYC6_0091340 ⚠ geranylgeranyl transferase type II beta subun	—	OG7 LdBPK_181220.1 ↔ LdBPK_261450.1 OG7 LdBPK_181230.1 ↔ LdBPK_261450.1	OG7
TcYC6_0057730 hypothetical protein, conserved	—	OG7 LdBPK_181230.1 ↔ LdBPK_261260.1	OG7
TcYC6_0080710 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-bisphos	—	OG7 TCSYLVIO_004468 ↔ TCSYLVIO_006246	OG7
TcYC6_0056900 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-biphosp	—	OG7 TCSYLVIO_004468 ↔ TCSYLVIO_006246	OG7
TcYC6_0121960 ⚠ ubiquitin-protein ligase, putative	—	OG7 LdBPK_161180.1 ↔ LdBPK_181220.1 OG7 LdBPK_161180.1 ↔ LdBPK_181230.1 OG7 LdBPK_181230.1 ↔ LdBPK_300970.1	OG7
TcYC6_0092100 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_161180.1 ↔ LdBPK_181220.1 OG7 LdBPK_161180.1 ↔ LdBPK_181230.1 OG7 LdBPK_181230.1 ↔ LdBPK_300970.1	OG7
TcYC6_0099570 ⚠ ubiquitin-protein ligase-like, putative	—	OG7 LdBPK_161180.1 ↔ LdBPK_181220.1 OG7 LdBPK_161180.1 ↔ LdBPK_181230.1 OG7 LdBPK_181230.1 ↔ LdBPK_300970.1	OG7
TcYC6_0072780 ⚠ aminopeptidase, putative,metallo-peptidase, C	—	OG7 LdBPK_110640.1 ↔ LdBPK_181220.1 OG7 LdBPK_110640.1 ↔ LdBPK_181230.1	OG7
TcYC6_0080250 ⚠ zinc-finger of a C2HC-type, putative	—	OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	OG7
TcYC6_0074310 ⚠ zinc-finger of a C2HC-type, putative	—	OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	OG7
TcYC6_0106500 hypothetical protein, conserved	—	OG6 TCSYLVIO_002919 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_002919 ↔ TCSYLVIO_006246	Both
TcYC6_0071320 hypothetical protein, conserved	—	OG6 LdBPK_181220.1 ↔ LdBPK_354870.1 OG6 LdBPK_181230.1 ↔ LdBPK_354870.1 OG7 LdBPK_181220.1 ↔ LdBPK_354870.1 OG7 LdBPK_181230.1 ↔ LdBPK_354870.1	Both
TcYC6_0112960 ⚠ inosine-5'-monophosphate dehydrogenase, putat	—	OG6 LdBPK_181220.1 ↔ LdBPK_191590.1 OG6 LdBPK_181230.1 ↔ LdBPK_191590.1 OG7 LdBPK_181220.1 ↔ LdBPK_191590.1 OG7 LdBPK_181230.1 ↔ LdBPK_191590.1	Both
TcYC6_0053280 hypothetical protein, conserved	—	OG6 LdBPK_181230.1 ↔ LdBPK_321100.1 OG7 LdBPK_181230.1 ↔ LdBPK_321100.1	Both
TcYC6_0067770 Casein kinase II	—	OG6 LdBPK_181220.1 ↔ LdBPK_351720.1 OG6 LdBPK_181230.1 ↔ LdBPK_351720.1	OG6
TcYC6_0110900 protein kinase, putative	—	OG6 LdBPK_181230.1 ↔ LdBPK_292600.1 OG7 LdBPK_181230.1 ↔ LdBPK_292600.1	Both
TcYC6_0115770 Zn-finger in Ran binding protein and others/F	—	OG6 LdBPK_180610.1 ↔ LdBPK_181220.1 OG6 LdBPK_180610.1 ↔ LdBPK_181230.1	OG6
TcYC6_0000440 Ankyrin repeats (3 copies)/Zinc finger, C3HC4	—	OG6 LdBPK_020120.1 ↔ LdBPK_181220.1 OG6 LdBPK_020120.1 ↔ LdBPK_181230.1	OG6
TcYC6_0093110 hypothetical protein	—	OG6 TCSYLVIO_001255 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_001255 ↔ TCSYLVIO_006246	Both
TcYC6_0043350 zinc finger ccch and cchc domain-containing p	—	OG6 LdBPK_110930.1 ↔ LdBPK_181220.1 OG6 LdBPK_110930.1 ↔ LdBPK_181230.1 OG7 LdBPK_110930.1 ↔ LdBPK_181220.1 OG7 LdBPK_110930.1 ↔ LdBPK_181230.1	Both
TcYC6_0084300 DNA-damage inducible protein DDI1-like protei	—	OG6 TCSYLVIO_003428 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_003428 ↔ TCSYLVIO_006246	Both
TcYC6_0102190 N(2), N(2)-dimethylguanosine tRNA methyltrans	—	OG6 TCSYLVIO_002844 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_002844 ↔ TCSYLVIO_006246	Both
TcYC6_0123380 hypothetical protein, conserved	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006246	Both
TcYC6_0116260 putative 5-oxoprolinase	—	OG6 LdBPK_181050.1 ↔ LdBPK_181220.1 OG6 LdBPK_181050.1 ↔ LdBPK_181230.1 OG7 LdBPK_181050.1 ↔ LdBPK_181220.1 OG7 LdBPK_181050.1 ↔ LdBPK_181230.1	Both
TcYC6_0043390 hypothetical protein, conserved	—	OG6 LdBPK_110890.1 ↔ LdBPK_181220.1 OG6 LdBPK_110890.1 ↔ LdBPK_181230.1 OG7 LdBPK_110890.1 ↔ LdBPK_181220.1 OG7 LdBPK_110890.1 ↔ LdBPK_181230.1	Both
TcYC6_0096230 hypothetical protein, conserved	—	OG6 TCSYLVIO_003179 ↔ TCSYLVIO_006246 OG7 TCSYLVIO_003179 ↔ TCSYLVIO_006246	Both
TcYC6_0060680 ⚠ Centrosomal protein of 164 kDa, putative	—	OG6 LdBPK_120470.1 ↔ LdBPK_181220.1 OG6 LdBPK_120470.1 ↔ LdBPK_181230.1 OG7 LdBPK_120470.1 ↔ LdBPK_181220.1 OG7 LdBPK_120470.1 ↔ LdBPK_181230.1	Both
TcYC6_0065870 hypothetical protein, conserved	—	OG6 LdBPK_080420.1 ↔ LdBPK_181220.1 OG6 LdBPK_080420.1 ↔ LdBPK_181230.1 OG7 LdBPK_080420.1 ↔ LdBPK_181220.1 OG7 LdBPK_080420.1 ↔ LdBPK_181230.1	Both
TcYC6_0042410 ⚠ zinc-finger of a C2HC-type, putative	—	OG7 TCSYLVIO_006138 ↔ TCSYLVIO_006246	OG7

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