TcYC6_0116260

putative 5-oxoprolinase
Trypanosoma cruzi Y C6 OG6: OG6_100892 OG7: OG7_0005437 111 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 111 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0121920 ⚠
poly(A)-specific ribonuclease PARN, putative
— Both
TcYC6_0031230 ⚠
poly(A)-specific ribonuclease PARN, putative
— Both
TcYC6_0068420 ⚠
poly(A)-specific ribonuclease PARN, putative
— OG7
TcYC6_0092100 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0048370 ⚠
GMP reductase
— OG6
TcYC6_0077260
translation initiation factor IF-2, putative
— Both
TcYC6_0083670
tubulin folding cofactor D, putative
— Both
TcYC6_0125510
hypothetical protein, conserved
— Both
TcYC6_0031370
5'-AMP-activated protein kinase subunit beta,
— Both
TcYC6_0040350 ⚠
PPPDE putative peptidase domain containing pr
— Both
TcYC6_0110770
aspartyl aminopeptidase, putative
— Both
TcYC6_0072080
hypothetical protein, conserved
— Both
TcYC6_0040300 ⚠
PPPDE putative peptidase domain containing pr
— Both
TcYC6_0080930 ⚠
pyruvate dehydrogenase (lipoamide) kinase, pu
— Both
TcYC6_0022010
hypothetical protein, conserved
— Both
TcYC6_0116560
prolyl-tRNA synthetase, putative
— Both
TcYC6_0095370
hypothetical protein, conserved
— Both
TcYC6_0069310
hypothetical protein, conserved
— Both
TcYC6_0009740
CHAT domain containing protein, putative
— Both
TcYC6_0089430 ⚠
asparaginyl-tRNA synthetase, putative
— Both
TcYC6_0112960 ⚠
inosine-5'-monophosphate dehydrogenase, putat
— Both
TcYC6_0009900
vacuolar protein sorting-associated protein 3
— Both
TcYC6_0067770
Casein kinase II
— OG6
TcYC6_0109430 ⚠
Ankyrin repeats (many copies)/Ankyrin repeats
— Both
TcYC6_0069150
hypothetical protein, conserved
— Both
TcYC6_0024770 ⚠
mitochondrial exoribonuclease DSS-1, putative
— OG7
TcYC6_0116650 ⚠
cholinephosphate cytidylyltransferase A, puta
— OG7
TcYC6_0072780 ⚠
aminopeptidase, putative,metallo-peptidase, C
— OG7
TcYC6_0095890 ⚠
ubiquitin-protein ligase
— OG7
TcYC6_0104830 ⚠
CRAL/TRIO domain containing protein, putative
— OG7
TcYC6_0090760 ⚠
Programmed cell death protein 2, C-terminal p
— OG7
TcYC6_0127520 ⚠
ATP-dependent RNA helicase MTR4
— OG7
TcYC6_0100560
Domain of unknown function (DUF3437), putativ
— OG7
TcYC6_0042180 ⚠
Ankyrin repeats (3 copies), putative
— OG7
TcYC6_0116450 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0068720 ⚠
ankyrin repeat protein, putative
— OG7
TcYC6_0107860 ⚠
nuclear transcription factor, putative
— OG7
TcYC6_0091190 ⚠
Histidine kinase-, DNA gyrase B-, and HSP90-l
— OG7
TcYC6_0023910 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0107480 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0022580 ⚠
aspartyl-tRNA synthetase, putative
— OG7
TcYC6_0095250 ⚠
aspartyl-tRNA synthetase, putative
— OG7
TcYC6_0104800 ⚠
CRAL/TRIO domain containing protein, putative
— OG7
TcYC6_0071890 ⚠
ribosome-interacting GTPase 2, putative
— OG7
TcYC6_0091340 ⚠
geranylgeranyl transferase type II beta subun
— OG7
TcYC6_0102100 ⚠
mitochondrial processing peptidase alpha subu
— OG7
TcYC6_0009400 ⚠
mitochondrial processing peptidase alpha subu
— OG7
TcYC6_0052970 ⚠
PPPDE putative peptidase domain containing pr
— OG7
TcYC6_0121960 ⚠
ubiquitin-protein ligase, putative
— OG7
TcYC6_0109960
hypothetical protein, conserved
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.