TcYC6_0056900

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase, putative
Trypanosoma cruzi Y C6 OG6: OG6_132778 OG7: OG7_0002306 159 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 159 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0069000 ⚠
Leucine carboxyl methyltransferase/Cupin-like
— OG7
TcYC6_0124680 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0080770 ⚠
leucine carboxyl methyltransferase, putative
— OG7
TcYC6_0126040 ⚠
Ribosomal protein S5, C-terminal domain conta
— OG7
TcYC6_0018650 ⚠
CMGC/DYRK protein kinase, putative
— OG7
TcYC6_0021670 ⚠
ATP synthase, putative
— OG7
TcYC6_0070640 ⚠
synaptojanin (N-terminal domain), putative
— OG7
TcYC6_0021990 ⚠
protein kinase PK4, putative
— OG7
TcYC6_0042410 ⚠
zinc-finger of a C2HC-type, putative
— OG7
TcYC6_0142880 ⚠
retrotransposon hot spot (RHS) protein, putat
— OG7
TcYC6_0123030 ⚠
beta adaptin, putative
— OG7
TcYC6_0072050 ⚠
Tcc1i14-2.10
— OG7
TcYC6_0071910 ⚠
isopentenyl-diphosphate delta-isomerase (type
— OG7
TcYC6_0023240 ⚠
Domain of unknown function (DUF4042), putativ
— OG7
TcYC6_0005960 ⚠
Adaptor protein complex AP-3 subunit beta-3
— OG7
TcYC6_0074310 ⚠
zinc-finger of a C2HC-type, putative
— OG7
TcYC6_0079620 ⚠
endonuclease/exonuclease/phosphatase, putativ
— OG7
TcYC6_0007440 ⚠
ATP synthase, putative
— OG7
TcYC6_0120160 ⚠
putative COP9 signalosome complex subunit 2
— OG7
TcYC6_0115230 ⚠
zinc-finger of a C2HC-type/Double zinc ribbon
— OG7
TcYC6_0015370 ⚠
aspartyl-tRNA synthetase, putative
— OG7
TcYC6_0116640 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0108590 ⚠
heat shock protein 90, putative
— OG7
TcYC6_0073050 ⚠
Eukaryotic translation initiation factor 4E-1
— OG7
TcYC6_0115710 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0018460 ⚠
CMGC/DYRK protein kinase, putative
— OG7
TcYC6_0095240 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
TcYC6_0080250 ⚠
zinc-finger of a C2HC-type, putative
— OG7
TcYC6_0072610 ⚠
heat shock protein 84, putative
— OG7
TcYC6_0081730 ⚠
putative synaptojanin
— OG7
TcYC6_0095250 ⚠
aspartyl-tRNA synthetase, putative
— OG7
TcYC6_0022580 ⚠
aspartyl-tRNA synthetase, putative
— OG7
TcYC6_0021740 ⚠
2-oxoisovalerate dehydrogenase alpha subunit,
— OG7
TcYC6_0047190 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0123410 ⚠
CMGC/DYRK protein kinase, putative
— OG7
TcYC6_0005860 ⚠
vacuolar protein sorting-associated protein-l
— OG7
TcYC6_0113040 ⚠
eukaryotic translation initiation factor 4E (
— OG7
TcYC6_0048300 ⚠
CMGC/CLK family protein kinase, putative
— OG7
TcYC6_0023910 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0006410 ⚠
vacuolar protein sorting-associated protein-l
— OG7
TcYC6_0116560 ⚠
prolyl-tRNA synthetase, putative
— OG7
TcYC6_0041650 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0080720 ⚠
PUB domain containing protein, putative
— OG7
TcYC6_0052930 ⚠
G5-interacting protein, putative
— OG7
TcYC6_0114880 ⚠
Hsp70 protein, putative
— OG7
TcYC6_0012460 ⚠
leucine rich repeat
— OG7
TcYC6_0013090 ⚠
oxidoreductase-like protein, putative
— OG7
TcYC6_0082160 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0011370 ⚠
heat shock protein 70
— OG7
TcYC6_0081220 ⚠
hypothetical protein, conserved
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.