TcYC6_0073050

Eukaryotic translation initiation factor 4E-1
Trypanosoma cruzi Y C6 OG6: OG6_100627 OG7: OG7_0002303 236 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 236 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0053340 ⚠
Vps23 core domain containing protein, putativ
— OG7
TcYC6_0060680 ⚠
Centrosomal protein of 164 kDa, putative
— OG7
TcYC6_0012030 ⚠
hypothetical protein
— OG7
TcYC6_0048910 ⚠
5'-3' exoribonuclease B, putative
— OG7
TcYC6_0044720 ⚠
haloacid dehalogenase hydrolase, putative
— OG7
TcYC6_0000450 ⚠
Vps51/Vps67, putative
— OG7
TcYC6_0092450 ⚠
carnitine O-palmitoyltransferase II, putative
— OG7
TcYC6_0073110 ⚠
choline/carnitine O-acetyltransferase, putati
— OG7
TcYC6_0025610 ⚠
choline/carnitine O-acyltransferase , putativ
— OG7
TcYC6_0112990 ⚠
choline/carnitine O-acyltransferase , putativ
— OG7
TcYC6_0049090 ⚠
carnitine O-acetyltransferase
— OG7
TcYC6_0091270 ⚠
AP-1 adapter complex gamma subunit, putative
— OG7
TcYC6_0099160 ⚠
alpha-adaptin-like, putative
— OG7
TcYC6_0088810 ⚠
Protein of unknown function (DUF3808), putati
— OG7
TcYC6_0077310 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0112470 ⚠
Conserved oligomeric complex COG6, putative
— OG7
TcYC6_0071320 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0089430 ⚠
asparaginyl-tRNA synthetase, putative
— OG7
TcYC6_0095370 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0023910 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0125890 ⚠
neurobeachin/beige protein
— OG7
TcYC6_0125900 ⚠
Sec34-like family, putative
— OG7
TcYC6_0072080 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0022580 ⚠
aspartyl-tRNA synthetase, putative
— OG7
TcYC6_0095250 ⚠
aspartyl-tRNA synthetase, putative
— OG7
TcYC6_0005990 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0077260 ⚠
translation initiation factor IF-2, putative
— OG7
TcYC6_0015370 ⚠
aspartyl-tRNA synthetase, putative
— OG7
TcYC6_0044540 ⚠
neurobeachin/beige-like protein
— OG7
TcYC6_0072660 ⚠
hypothetical protein
— OG7
TcYC6_0111530 ⚠
6-phosphofructo-2-kinase 1
— OG7
TcYC6_0014450 ⚠
ribosomal protein S29, putative
— OG7
TcYC6_0014440 ⚠
ribosomal protein S29, putative
— OG7
TcYC6_0014410 ⚠
ribosomal protein S29, putative
— OG7
TcYC6_0093550 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0095890 ⚠
ubiquitin-protein ligase
— OG7
TcYC6_0099570 ⚠
ubiquitin-protein ligase-like, putative
— OG7
TcYC6_0055300 ⚠
WW domain containing protein, putative
— OG7
TcYC6_0092100 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0121960 ⚠
ubiquitin-protein ligase, putative
— OG7
TcYC6_0101550 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0101540 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0080950 ⚠
clathrin coat assembly protein, putative
— OG7
TcYC6_0056900 ⚠
6-phosphofructo-2-kinase/fructose-2,6-biphosp
— OG7
TcYC6_0080710 ⚠
6-phosphofructo-2-kinase/fructose-2,6-bisphos
— OG7
TcYC6_0075770 ⚠
aldo-keto reductase, putative
— OG7
TcYC6_0069360 ⚠
replication factor C, subunit 3, putative
— OG7
TcYC6_0016870 ⚠
Replication Factor C Subunit 1-related protei
— OG7
TcYC6_0034660 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0081900 ⚠
putative replication factor C, subunit 1
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.