TcYC6_0080710

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, putative
Trypanosoma cruzi Y C6 OG6: OG6_129420 OG7: OG7_0002306 151 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 151 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TcYC6_0124680 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0069000 ⚠
Leucine carboxyl methyltransferase/Cupin-like
— OG7
TcYC6_0080770 ⚠
leucine carboxyl methyltransferase, putative
— OG7
TcYC6_0044380 ⚠
seryl-tRNA synthetase
— OG7
TcYC6_0047190 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0123410 ⚠
CMGC/DYRK protein kinase, putative
— OG7
TcYC6_0005860 ⚠
vacuolar protein sorting-associated protein-l
— OG7
TcYC6_0113040 ⚠
eukaryotic translation initiation factor 4E (
— OG7
TcYC6_0061220 ⚠
helicase, putative
— OG7
TcYC6_0046920 ⚠
vacuolar ATP synthase subunit d
— OG7
TcYC6_0053470 ⚠
phenylalanyl-tRNA synthetase alpha chain, put
— OG7
TcYC6_0091400 ⚠
GRIP domain containing protein, putative
— OG7
TcYC6_0048300 ⚠
CMGC/CLK family protein kinase, putative
— OG7
TcYC6_0023910 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0006410 ⚠
vacuolar protein sorting-associated protein-l
— OG7
TcYC6_0116560 ⚠
prolyl-tRNA synthetase, putative
— OG7
TcYC6_0126040 ⚠
Ribosomal protein S5, C-terminal domain conta
— OG7
TcYC6_0091190 ⚠
Histidine kinase-, DNA gyrase B-, and HSP90-l
— OG7
TcYC6_0028200 ⚠
putative inositol/phosphatidylinositol phosph
— OG7
TcYC6_0031670 ⚠
pteridine reductase
— OG7
TcYC6_0072130 ⚠
hypothetical protein
— OG7
TcYC6_0085910 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0064660 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0095370 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0011990 ⚠
Vacuolar proton pump subunit B, putative
— OG7
TcYC6_0047040 ⚠
NADH-dependent fumarate reductase
— OG7
TcYC6_0146170 ⚠
retrotransposon hot spot (RHS) protein, putat
— OG7
TcYC6_0104220 ⚠
hypothetical protein
— OG7
TcYC6_0089430 ⚠
asparaginyl-tRNA synthetase, putative
— OG7
TcYC6_0084200 ⚠
ubiquitin activating enzyme, putative
— OG7
TcYC6_0022120 ⚠
ATP synthase F1 subunit gamma protein, putati
— OG7
TcYC6_0120590 ⚠
putative Leucine rich repeat
— OG7
TcYC6_0114860 ⚠
Histone chaperone Rttp106-like, putative
— OG7
TcYC6_0068480 ⚠
ubiquitin hydrolase, putative
— OG7
TcYC6_0108150 ⚠
Hsc70-interacting protein, putative
— OG7
TcYC6_0034830 ⚠
CMGC/DYRK protein kinase, putative
— OG7
TcYC6_0120270 ⚠
putative Leucine rich repeat
— OG7
TcYC6_0073500 ⚠
ubiquitin carboxyl-terminal hydrolase, putati
— OG7
TcYC6_0091590 ⚠
hypothetical protein
— OG7
TcYC6_0024860 ⚠
adenylosuccinate lyase, putative
— OG7
TcYC6_0114880 ⚠
Hsp70 protein, putative
— OG7
TcYC6_0077600 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0081220 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0080720 ⚠
PUB domain containing protein, putative
— OG7
TcYC6_0052930 ⚠
G5-interacting protein, putative
— OG7
TcYC6_0041650 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0013090 ⚠
oxidoreductase-like protein, putative
— OG7
TcYC6_0015620 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0103230 ⚠
hypothetical protein, conserved
— OG7
TcYC6_0012460 ⚠
leucine rich repeat
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.