TvY486_1106950

metallo-peptidase, Clan MF, Family M17

Trypanosoma vivax Y486 OG6: OG6_142599 OG7: OG7_0003405 279 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 279 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
TvY486_0101330 ⚠ amidohydrolase, putative	—	OG6 LdBPK_110630.1 ↔ LdBPK_201720.1 OG6 LdBPK_110640.1 ↔ LdBPK_201720.1 OG6 LdBPK_110630.1 ↔ LdBPK_201740.1 OG6 LdBPK_110640.1 ↔ LdBPK_201740.1 +9 more	Both
TvY486_0101320 ⚠ amidohydrolase, putative	—	OG6 LdBPK_110630.1 ↔ LdBPK_201720.1 OG6 LdBPK_110640.1 ↔ LdBPK_201720.1 OG6 LdBPK_110630.1 ↔ LdBPK_201740.1 OG6 LdBPK_110640.1 ↔ LdBPK_201740.1 +9 more	Both
TvY486_1111170 ⚠ hypothetical protein, conserved	—	OG6 LdBPK_110630.1 ↔ LdBPK_364240.1 OG6 LdBPK_110640.1 ↔ LdBPK_364240.1 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008197 OG7 LdBPK_110630.1 ↔ LdBPK_364240.1 +2 more	Both
TvY486_0402160 ⚠ asparaginyl-tRNA synthetase, putative	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG6 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 +1 more	Both
TvY486_0902890 ⚠ calpain-like cysteine peptidase, putative, cy	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_007342 OG6 Tb927.11.6590 ↔ Tb927.9.7540	OG6
TvY486_0601330 ⚠ aspartyl-tRNA synthetase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	OG7
TvY486_1009060 ⚠ isoleucyl-tRNA synthetase, putative	—	OG6 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
TvY486_1108060 ⚠ rrp44p homologue, putative	—	OG6 LdBPK_110630.1 ↔ LdBPK_280470.1 OG6 LdBPK_110640.1 ↔ LdBPK_280470.1 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 +2 more	Both
TvY486_0500500 ⚠ NADH-dependent fumarate reductase, putative	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
TvY486_1003670 ⚠ NADH-dependent fumarate reductase, putative	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG6 LdBPK_110630.1 ↔ LdBPK_350850.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 +2 more	Both
TvY486_0100940 ⚠ calpain-like cysteine peptidase, putative, cy	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_007342 OG6 Tb927.11.6590 ↔ Tb927.9.7540	OG6
TvY486_0902820 ⚠ mitochondrial exoribonuclease DSS-1, putative	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 OG7 LdBPK_110640.1 ↔ LdBPK_280470.1	OG7
TvY486_1109070 ⚠ ribonuclease II-like protein, putative, (frag	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 OG7 LdBPK_110640.1 ↔ LdBPK_280470.1	OG7
TvY486_0901510 ⚠ DNA-damage inducible protein DDI1-like protei	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003428 OG6 LdBPK_010630.1 ↔ LdBPK_110630.1 OG6 LdBPK_010630.1 ↔ LdBPK_110640.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003428 +3 more	Both
TvY486_0502690 ⚠ WD domain, G-beta repeat, putative	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG6 LdBPK_080420.1 ↔ LdBPK_110640.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_110640.1	Both
TvY486_0601730 ⚠ hypothetical protein, conserved (fragment)	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003145 OG6 LdBPK_110630.1 ↔ LdBPK_300810.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003145 OG7 LdBPK_110630.1 ↔ LdBPK_300810.1	Both
TvY486_0601460 ⚠ hypothetical protein, conserved	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG6 LdBPK_110640.1 ↔ LdBPK_300580.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG7 LdBPK_110640.1 ↔ LdBPK_300580.1	Both
TvY486_0020590 ⚠ hypothetical protein, conserved in T.vivax	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_006596 OG7 TCSYLVIO_000702 ↔ TCSYLVIO_001670	OG7
TvY486_1004640 ⚠ peptidyl-prolyl cis-trans isomerase, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_291330.1 OG7 LdBPK_110640.1 ↔ LdBPK_291330.1 OG7 LdBPK_291330.1 ↔ LdBPK_332700.1	OG7
TvY486_1107120 ⚠ regulator of chromatin condensation, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
TvY486_0400380 ⚠ hypothetical protein, conserved	—	OG7 LdBPK_332700.1 ↔ LdBPK_343890.1	OG7
TvY486_1014960 ⚠ macrophage infectivity potentiator, precursor	—	OG7 LdBPK_110630.1 ↔ LdBPK_291330.1 OG7 LdBPK_110640.1 ↔ LdBPK_291330.1 OG7 LdBPK_291330.1 ↔ LdBPK_332700.1	OG7
TvY486_0907260 ⚠ ubiquitin hydrolase, putative, cysteine pepti	—	OG7 LdBPK_332700.1 ↔ LdBPK_343890.1	OG7
TvY486_0801730 ⚠ tryptophanyl-tRNA synthetase, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_290060.1 OG7 LdBPK_110640.1 ↔ LdBPK_290060.1 OG7 LdBPK_290060.1 ↔ LdBPK_332700.1	OG7
TvY486_1102360 ⚠ mRNA export factor MEX67	—	OG7 LdBPK_110630.1 ↔ LdBPK_271580.1 OG7 LdBPK_110640.1 ↔ LdBPK_271580.1 OG7 LdBPK_271580.1 ↔ LdBPK_332700.1	OG7
TvY486_0006090 ⚠ peptidylprolyl isomerase-like, putative (frag	—	OG7 LdBPK_110630.1 ↔ LdBPK_291330.1 OG7 LdBPK_110640.1 ↔ LdBPK_291330.1 OG7 LdBPK_291330.1 ↔ LdBPK_332700.1	OG7
TvY486_1111190 ⚠ regulator of chromosome condensation 1-like p	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
TvY486_0033520 ⚠ ubiquitin hydrolase, putative	—	OG7 LdBPK_332700.1 ↔ LdBPK_343890.1	OG7
TvY486_1003730 ⚠ proteasome activator protein pa26, putative	—	OG7 LdBPK_332700.1 ↔ LdBPK_350770.1	OG7
TvY486_0703300 ⚠ peptidyl-prolyl cis-trans isomerase, putative	—	OG7 LdBPK_110630.1 ↔ LdBPK_291330.1 OG7 LdBPK_110640.1 ↔ LdBPK_291330.1 OG7 LdBPK_291330.1 ↔ LdBPK_332700.1	OG7
TvY486_0402550 ⚠ Regulator of chromosome condensation (RCC1) r	—	OG7 LdBPK_110630.1 ↔ LdBPK_260720.1 OG7 LdBPK_110640.1 ↔ LdBPK_260720.1 OG7 LdBPK_260720.1 ↔ LdBPK_332700.1	OG7
TvY486_0401810 ⚠ acyl-CoA binding protein, putative	—	OG7 LdBPK_090800.1 ↔ LdBPK_110630.1 OG7 LdBPK_090800.1 ↔ LdBPK_332700.1 OG7 LdBPK_090800.1 ↔ LdBPK_110640.1	OG7
TvY486_0006340 ⚠ elongation factor 1-alpha, putative (fragment	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
TvY486_0705480 ⚠ Acyl CoA binding protein, putative	—	OG7 LdBPK_090800.1 ↔ LdBPK_110630.1 OG7 LdBPK_090800.1 ↔ LdBPK_332700.1 OG7 LdBPK_090800.1 ↔ LdBPK_110640.1	OG7
TvY486_1002080 ⚠ elongation factor 1-alpha, putative	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
TvY486_1002090 ⚠ elongation factor 1-alpha, putative (fragment	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
TvY486_0904800 ⚠ elongation factor 1-alpha, putative	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
TvY486_1103630 ⚠ Acyl CoA binding protein, putative	—	OG7 LdBPK_090800.1 ↔ LdBPK_110630.1 OG7 LdBPK_090800.1 ↔ LdBPK_332700.1 OG7 LdBPK_090800.1 ↔ LdBPK_110640.1	OG7
TvY486_1002100 ⚠ elongation factor 1-alpha, putative	—	OG7 LdBPK_111160.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_111160.1 OG7 LdBPK_110640.1 ↔ LdBPK_111160.1	OG7
TvY486_0906670 ⚠ ubiquitin hydrolase, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005374	OG7
TvY486_0028820 ⚠ hypothetical protein, conserved in T.vivax	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_006596 OG7 TCSYLVIO_000702 ↔ TCSYLVIO_001670	OG7
TvY486_0904770 ⚠ synaptojanin (N-terminal domain), putative, (	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_007569	OG7
TvY486_1001500 ⚠ methionyl-tRNA synthetase, putative, (fragmen	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_007991	OG7
TvY486_1002400 ⚠ Lupus La protein homolog, putative	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_006827	OG7
TvY486_0301590 ⚠ eukaryotic translation initiation factor 3 su	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_006404	OG7
TvY486_0001070 ⚠ methionyl-tRNA synthetase, putative (fragment	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_007991	OG7
TvY486_1101900 ⚠ ubiquitin carboxyl-terminal hydrolase, putati	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005374	OG7
TvY486_1005550 ⚠ endonuclease/exonuclease/phosphatase, putativ	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_007569	OG7
TvY486_0302990 ⚠ heat shock protein 90, putative	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008621 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_009400 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_009151 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_005578	OG7
TvY486_0905830 ⚠ Peroxin 19	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_005818	OG7

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