TvY486_1112580

DNA topoisomerase II, putative, (fragment)
Trypanosoma vivax Y486 OG6: OG6_100284 OG7: OG7_0003182 16 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Network view all shared interactors, plus up to 150 more
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Interactions 16 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
TvY486_1108080 ⚠
cystathionine beta-synthase, putative
— Both
TvY486_0706530 ⚠
hypothetical protein, conserved
— Both
TvY486_0802390 ⚠
hypothetical protein, conserved
— Both
TvY486_0704970 ⚠
5'-3' exoribonuclease A, putative
— Both
TvY486_1006180 ⚠
5'-3' exoribonuclease D, putative
— Both
TvY486_0705035 ⚠
hypothetical protein, conserved
— Both
TvY486_0902770 ⚠
hypothetical protein, conserved
— Both
TvY486_0502180 ⚠
mitochondrial DNA polymerase beta-PAK, putati
— Both
TvY486_1104230 ⚠
hypothetical protein, conserved (fragment)
— Both
TvY486_0201200 ⚠
hypothetical protein, conserved
— Both
TvY486_0800460 ⚠
phosphoacetylglucosamine mutase, putative, (f
— Both
TvY486_0503450 ⚠
hypothetical protein, conserved
— Both
TvY486_1008600 ⚠
AAA domain containing protein, putative
— Both
TvY486_0503820 ⚠
nucleolar RNA helicase II, putative, (fragmen
— Both
TvY486_0502160 ⚠
mitochondrial DNA polymerase beta, putative
— OG7
TvY486_0005970 ⚠
5'-3' exonuclease, putative
— OG7
Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.