C4B63_4g197

DNA-directed RNA polymerase I subunit RPB5z
Trypanosoma cruzi Dm28c 2018 OG6: OG6_147556 OG7: OG7_0005341 51 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 51 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_6g1831c ⚠
DNA-dependent RNA polymerases
— OG7
C4B63_2g2395c ⚠
DNA-directed RNA polymerase II
— OG7
C4B63_230g118c ⚠
DNA-dependent RNA polymerases
— OG7
C4B63_10g507 ⚠
DNA-directed RNA polymerases I and III subuni
— OG7
C4B63_12g1641c ⚠
DNA-directed RNA polymerase I subunit RPB10
— OG7
C4B63_46g417c ⚠
DNA-directed RNA polymerase I subunit
— OG7
C4B63_304g10 ⚠
DNA-directed RNA polymerase III subunit C11
— OG7
C4B63_10g482
conserved hypothetical protein
— OG7
C4B63_104g76 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_104g75 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_49g106 ⚠
histone H2A
— OG7
C4B63_358g16 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_5g418 ⚠
DNA-directed RNA polymerase III subunit
— OG7
C4B63_255g16 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_17g120 ⚠
RNA polymerase-like protein
— OG7
C4B63_44g250 ⚠
DNA-directed RNA polymerase II subunit 2
— OG7
C4B63_321g29 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_47g56 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_242g10 ⚠
histone H2A
— OG7
C4B63_194g21 ⚠
DNA-directed RNA polymerase III
— OG7
C4B63_267g91c ⚠
DNA-directed RNA polymerase I subunit RPB10
— OG7
C4B63_279g5 ⚠
DNA-directed RNA polymerase II subunit 2
— OG7
C4B63_1g75 ⚠
DNA-directed RNA polymerase III subunit
— OG7
C4B63_19g82 ⚠
RNA polymerase I second largest subunit
— OG7
C4B63_12g246
conserved hypothetical protein
— OG7
C4B63_22g262c
DNA-directed RNA polymerase 2, RPB12 subunit
— OG7
C4B63_25g321
conserved hypothetical protein
— OG7
C4B63_2g165c ⚠
kinetoplastid membrane protein 11
— OG7
C4B63_55g67 ⚠
DNA-directed rna polymerase I largest subunit
— Both
C4B63_40g80 ⚠
DNA-directed RNA polymerase I subunit
— Both
C4B63_61g127 ⚠
histone H2A variant Z
— Both
C4B63_23g272
Uncharacterized protein YwhH
— OG7
C4B63_2g514
Reticulocyte-binding protein 2 homolog a
— OG7
C4B63_6g543
conserved hypothetical protein
— OG7
C4B63_20g214
conserved hypothetical protein
— OG7
C4B63_297g9 ⚠
conserved hypothetical protein
— OG7
C4B63_4g462
arginase
— OG7
C4B63_2g163c ⚠
kinetoplastid membrane protein 11
— OG7
C4B63_17g64 ⚠
conserved hypothetical protein
— OG7
C4B63_6g101
RNA polymerase B subunit RPB8
— OG7
C4B63_20g305
Uncharacterized protein C9orf85 homolog
— OG7
C4B63_83g24 ⚠
zinc-finger (CCCH type) protein
— OG7
C4B63_2g166c ⚠
kinetoplastid membrane protein 11
— OG7
C4B63_175g16
Pre-mRNA-processing factor 19
— OG7
C4B63_397g11 ⚠
zinc-finger CCCH domain containing protein 11
— OG7
C4B63_18g169 ⚠
Zinc finger CCCH domain-containing protein 47
— OG7
C4B63_12g2035c ⚠
zinc-finger protein 2
— OG7
C4B63_15g5 ⚠
zinc-finger CCCH domain containing protein 11
— OG7
C4B63_4g2794c ⚠
DNA-directed RNA polymerase III subunit C11
— OG7
C4B63_4g478 ⚠
DNA-directed RNA polymerases I and III subuni
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.