C4B63_55g67

DNA-directed rna polymerase I largest subunit
Trypanosoma cruzi Dm28c 2018 OG6: OG6_101773 OG7: OG7_0001854 183 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 183 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_19g82 ⚠
RNA polymerase I second largest subunit
— +3 more Both
C4B63_31g109 ⚠
ribose-phosphate pyrophosphokinase
— Both
C4B63_44g250 ⚠
DNA-directed RNA polymerase II subunit 2
— +1 more OG7
C4B63_279g6 ⚠
DNA-directed RNA polymerase II subunit 2
— +1 more OG7
C4B63_194g21 ⚠
DNA-directed RNA polymerase III
— +1 more OG7
C4B63_279g5 ⚠
DNA-directed RNA polymerase II subunit 2
— +1 more OG7
C4B63_4g478 ⚠
DNA-directed RNA polymerases I and III subuni
— +1 more Both
C4B63_10g507 ⚠
DNA-directed RNA polymerases I and III subuni
— OG7
C4B63_14g147 ⚠
phosphoribosylpyrophosphate synthetase
— OG7
C4B63_59g118 ⚠
phosphoribosylpyrophosphate synthetase
— OG7
C4B63_2g380 ⚠
phosphoribosylpyrophosphate synthetase
— OG7
C4B63_127g51 ⚠
acetyl-CoA carboxylase
— Both
C4B63_23g143 ⚠
dihydrolipoamide dehydrogenase
— OG7
C4B63_354g8 ⚠
damage-specific DNA binding protein
— Both
C4B63_51g90 ⚠
ATP-dependent RNA helicase
— Both
C4B63_25g185 ⚠
ATP-dependent RNA helicase
— Both
C4B63_31g46 ⚠
structural maintenance of chromosome 3 protei
— Both
C4B63_12g1641c ⚠
DNA-directed RNA polymerase I subunit RPB10
— Both
C4B63_46g417c ⚠
DNA-directed RNA polymerase I subunit
— Both
C4B63_267g91c ⚠
DNA-directed RNA polymerase I subunit RPB10
— Both
C4B63_52g72 ⚠
WD repeat-containing protein 3
— Both
C4B63_31g274 ⚠
tubulin tyrosine ligase
— OG6
C4B63_60g126 ⚠
tubulin tyrosine ligase
— OG6
C4B63_60g127 ⚠
tubulin tyrosine ligase
— OG6
C4B63_35g167 ⚠
tubulin tyrosine ligase
— OG6
C4B63_4g2794c ⚠
DNA-directed RNA polymerase III subunit C11
— OG7
C4B63_304g10 ⚠
DNA-directed RNA polymerase III subunit C11
— OG7
C4B63_26g318 ⚠
conserved hypothetical protein
— OG7
C4B63_136g39 ⚠
conserved hypothetical protein
— OG7
C4B63_49g106 ⚠
histone H2A
— OG7
C4B63_242g10 ⚠
histone H2A
— OG7
C4B63_104g76 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_104g75 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_358g16 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_255g16 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_124g2 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_34g361 ⚠
phosphatidylinositol kinase related protein
— OG7
C4B63_124g3 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_7g424 ⚠
phosphatidylinositol 3-kinase(fragment)
— OG7
C4B63_9g329 ⚠
Beige/BEACH domain
— OG7
C4B63_48g124 ⚠
neurobeachin/beige protein
— OG7
C4B63_48g123 ⚠
neurobeachin/beige protein
— OG7
C4B63_9g327 ⚠
conserved hypothetical protein
— OG7
C4B63_249g22 ⚠
dihydrolipoamide dehydrogenase
— OG7
C4B63_14g103 ⚠
beta adaptin
— OG7
C4B63_30g181 ⚠
rRNA methyltransferase 1, mitochondrial
— OG7
C4B63_25g186 ⚠
formin
— OG7
C4B63_9g328 ⚠
conserved hypothetical protein
— OG7
C4B63_63g101 ⚠
Phosphatidylinositol 3-kinase tor1
— OG7
C4B63_2g215 ⚠
PIH1 domain-containing protein 1
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.