C4B63_2g215

PIH1 domain-containing protein 1
Trypanosoma cruzi Dm28c 2018 OG6: OG6_104875 OG7: OG7_0006226 90 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 90 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_80g31 ⚠
Dynein assembly factor 4, axonemal
— OG7
C4B63_76g57 ⚠
Tripartite attachment complex protein 102
— OG7
C4B63_49g74 ⚠
MORN repeat-containing protein 5
— OG7
C4B63_6g279 ⚠
Coatomer subunit gamma
— OG7
C4B63_87g20 ⚠
Brefeldin A-inhibited guanine nucleotide-exch
— OG7
C4B63_10g126 ⚠
conserved hypothetical protein
— OG7
C4B63_28g54 ⚠
Dynein intermediate chain 1, axonemal
— OG7
C4B63_76g58 ⚠
Tripartite attachment complex protein 102
— OG7
C4B63_7g57 ⚠
Brefeldin A-inhibited guanine nucleotide-exch
— OG7
C4B63_87g21 ⚠
conserved hypothetical protein
— OG7
C4B63_9g306 ⚠
dynein intermediate chain
— OG7
C4B63_7g55 ⚠
conserved hypothetical protein
— OG7
C4B63_18g223 ⚠
eukaryotic translation initiation factor 3 su
— OG7
C4B63_4g526 ⚠
conserved hypothetical protein
— OG7
C4B63_81g14 ⚠
guanine-nucleotide exchange factor, Sec7
— OG7
C4B63_137g10 ⚠
Coatomer subunit gamma
— OG7
C4B63_24g273 ⚠
Probable E3 ubiquitin-protein ligase HERC1
— OG7
C4B63_52g136 ⚠
Cytoplasmic dynein 1 intermediate chain
— OG7
C4B63_11g83 ⚠
Eukaryotic translation initiation factor 3 su
— OG7
C4B63_54g50 ⚠
conserved hypothetical protein
— OG7
C4B63_24g272 ⚠
Zn-finger in Ran binding protein and others/S
— OG7
C4B63_55g67 ⚠
DNA-directed rna polymerase I largest subunit
— OG7
C4B63_30g206 ⚠
conserved hypothetical protein
— OG7
C4B63_481g13 ⚠
MORN repeat-containing protein 5
— OG7
C4B63_52g168 ⚠
Cilia- and flagella-associated protein 44
— OG7
C4B63_84g21 ⚠
conserved hypothetical protein
— OG7
C4B63_84g22 ⚠
conserved hypothetical protein
— OG7
C4B63_16g290 ⚠
mitochondrial RNA binding protein
— OG7
C4B63_286g18 ⚠
eukaryotic translation initiation factor 3 su
— OG7
C4B63_7g68 ⚠
Brefeldin A-inhibited guanine nucleotide-exch
— OG7
C4B63_17g102 ⚠
conserved hypothetical protein
— OG7
C4B63_7g67 ⚠
Sec7 guanine-nucleotide exchange factor
— OG7
C4B63_7g421 ⚠
coatomer alpha subunit
— OG7
C4B63_63g7 ⚠
eukaryotic translation initiation factor 3 su
— OG7
C4B63_70g71 ⚠
conserved hypothetical protein
— OG7
C4B63_43g211 ⚠
conserved hypothetical protein
— OG7
C4B63_22g173 ⚠
coatomer beta subunit
— OG7
C4B63_21g277 ⚠
conserved hypothetical protein
— OG7
C4B63_10g514 ⚠
WD domain, G-beta repeat
— OG7
C4B63_19g120 ⚠
conserved hypothetical protein
— OG7
C4B63_19g121 ⚠
conserved hypothetical protein
— OG7
C4B63_20g322 ⚠
conserved hypothetical protein
— OG7
C4B63_7g56 ⚠
Protein transport protein sec71
— OG7
C4B63_81g15 ⚠
guanine-nucleotide exchange factor, Sec7
— OG7
C4B63_43g210 ⚠
conserved hypothetical protein
— OG7
C4B63_34g361 ⚠
phosphatidylinositol kinase related protein
— OG7
C4B63_25g310 ⚠
conserved hypothetical protein
— OG7
C4B63_137g44 ⚠
receptor for activated C kinase 1
— OG7
C4B63_137g48 ⚠
receptor for activated C kinase 1
— OG7
C4B63_18g20 ⚠
Protein will die slowly
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.