C4B63_7g67

Sec7 guanine-nucleotide exchange factor
Trypanosoma cruzi Dm28c 2018 OG6: OG6_143821 OG7: OG7_0001170 208 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 208 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_12g218 ⚠
Zinc finger HIT domain-containing protein 1
— OG7
C4B63_16g103 ⚠
conserved hypothetical protein
— OG7
C4B63_13g243 ⚠
intraflagellar transport protein 122B(fragmen
— OG7
C4B63_127g30 ⚠
Flagellum attachment zone protein 14
— OG7
C4B63_13g334 ⚠
conserved hypothetical protein
— OG7
C4B63_112g13 ⚠
neurobeachin/beige-like protein(fragment)
— OG7
C4B63_17g277 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_58g144 ⚠
Cilia- and flagella-associated protein 70
— OG7
C4B63_46g32 ⚠
E3 ubiquitin-protein ligase HERC2
— OG7
C4B63_8g48 ⚠
dynein arm light chain
— OG7
C4B63_248g25 ⚠
Centrosomal protein of 164 kDa
— OG7
C4B63_19g15 ⚠
translation initiation factor eIF2B delta sub
— OG7
C4B63_21g61 ⚠
guanine nucleotide exchange factor subunit GC
— OG7
C4B63_281g8 ⚠
translation initiation factor eIF2B delta sub
— OG7
C4B63_28g111 ⚠
synaptojanin
— OG7
C4B63_24g196 ⚠
microtubule-associated protein
— OG7
C4B63_17g276 ⚠
TRAF3-interacting protein 1
— OG7
C4B63_49g186 ⚠
ccr4-not transcription complex subunit
— OG7
C4B63_48g122 ⚠
neurobeachin/beige protein
— OG7
C4B63_20g38 ⚠
Synaptojanin
— OG7
C4B63_42g85 ⚠
conserved hypothetical protein
— OG7
C4B63_14g250 ⚠
Anaphase-promoting complex subunit 3
— OG7
C4B63_43g141 ⚠
conserved hypothetical protein
— OG7
C4B63_2g729 ⚠
structural maintenance of chromosome (SMC) fa
— OG7
C4B63_278g6 ⚠
endosomal trafficking protein RME-8
— OG7
C4B63_13g297 ⚠
Axonemal inner arm dynein light chain
— OG7
C4B63_24g194 ⚠
microtubule-associated protein
— OG7
C4B63_89g42 ⚠
translation initiation factor EIF-2b alpha su
— OG7
C4B63_204g23 ⚠
Axonemal inner arm dynein light chain
— OG7
C4B63_17g128 ⚠
cleavage and polyadenylation specificity fact
— OG7
C4B63_175g16 ⚠
Pre-mRNA-processing factor 19
— OG7
C4B63_11g50 ⚠
General negative regulator of transcription s
— OG7
C4B63_79g36 ⚠
CCR4-NOT transcription complex subunit 1
— OG7
C4B63_4g513 ⚠
Target of rapamycin complex subunit LST8
— OG7
C4B63_61g104 ⚠
conserved hypothetical protein
— OG7
C4B63_2g203 ⚠
synaptojanin (N-terminal domain)
— OG7
C4B63_22g113 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_55g168 ⚠
Cilia- and flagella-associated protein 57
— OG7
C4B63_24g195 ⚠
microtubule-associated protein
— OG7
C4B63_4g103 ⚠
intraflagellar transport protein 140
— OG7
C4B63_25g218 ⚠
Centrosomal protein of 164 kDa
— OG7
C4B63_41g73 ⚠
Centrosomal protein of 164 kDa
— OG7
C4B63_149g16 ⚠
conserved hypothetical protein
— OG7
C4B63_2g826 ⚠
conserved hypothetical protein
— OG7
C4B63_7g236 ⚠
regulatory subunit of protein kinase a-like p
— OG7
C4B63_31g46 ⚠
structural maintenance of chromosome 3 protei
— OG7
C4B63_102g78 ⚠
dynein arm light chain
— OG7
C4B63_4g506 ⚠
Microtubule Associated kinase (CAP-Gly domain
— OG7
C4B63_153g40 ⚠
inositol 5-phosphatase 1
— OG7
C4B63_1g57 ⚠
AAA ATPase
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.