C4B63_1g57

AAA ATPase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_112415 OG7: OG7_0016131 165 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 165 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_7g55 ⚠
conserved hypothetical protein
— OG7
C4B63_9g223 ⚠
Cilia- and flagella-associated protein 57
— Both
C4B63_4g103
intraflagellar transport protein 140
— Both
C4B63_293g23 ⚠
ATP-dependent DEAD/H RNA helicase(fragment)
— OG6
C4B63_17g45
kinesin
— OG6
C4B63_6g418
protein kinase
— Both
C4B63_149g16 ⚠
conserved hypothetical protein
— Both
C4B63_35g118 ⚠
conserved hypothetical protein
— OG6
C4B63_278g6 ⚠
endosomal trafficking protein RME-8
— Both
C4B63_18g71 ⚠
cyclosome subunit
— Both
C4B63_43g141
conserved hypothetical protein
— Both
C4B63_28g123 ⚠
conserved hypothetical protein
— Both
C4B63_63g98
ubiquitin-protein ligase
— OG6
C4B63_10g105 ⚠
kinesin protein
— OG6
C4B63_49g186
ccr4-not transcription complex subunit
— Both
C4B63_17g276 ⚠
TRAF3-interacting protein 1
— Both
C4B63_48g156 ⚠
conserved hypothetical protein
— OG6
C4B63_24g196 ⚠
microtubule-associated protein
— Both
C4B63_4g480 ⚠
Flagellum attachment zone protein 7(fragment)
— OG6
C4B63_48g155 ⚠
conserved hypothetical protein
— OG6
C4B63_8g48 ⚠
dynein arm light chain
— Both
C4B63_58g144
Cilia- and flagella-associated protein 70
— Both
C4B63_127g30 ⚠
Flagellum attachment zone protein 14
— Both
C4B63_13g334
conserved hypothetical protein
— Both
C4B63_13g243
intraflagellar transport protein 122B(fragmen
— Both
C4B63_16g103 ⚠
conserved hypothetical protein
— Both
C4B63_86g55 ⚠
Probable E3 ubiquitin-protein ligase HERC3
— OG6
C4B63_42g174
conserved hypothetical protein
— Both
C4B63_186g7 ⚠
cleavage and polyadenylation specificity fact
— Both
C4B63_18g325 ⚠
endosomal trafficking protein RME-8
— Both
C4B63_49g160 ⚠
ATP-dependent DEAD/H RNA helicase
— OG6
C4B63_18g72 ⚠
cyclosome subunit
— Both
C4B63_124g1 ⚠
phosphatidylinositol 3-kinase
— Both
C4B63_52g40
immunodominant antigen
— Both
C4B63_35g116 ⚠
VPS13A C
— OG6
C4B63_21g49
conserved hypothetical protein
— Both
C4B63_33g8 ⚠
Phosphatidylinositol 4-phosphate 5-kinase
— OG7
C4B63_29g3 ⚠
Phosphatidylinositol 4-phosphate 5-kinase
— OG7
C4B63_56g104 ⚠
Phosphatidylinositol 4-phosphate 5-kinase
— OG7
C4B63_81g15 ⚠
guanine-nucleotide exchange factor, Sec7
— OG7
C4B63_7g56 ⚠
Protein transport protein sec71
— OG7
C4B63_81g14 ⚠
guanine-nucleotide exchange factor, Sec7
— OG7
C4B63_102g78 ⚠
dynein arm light chain
— OG7
C4B63_2g729 ⚠
structural maintenance of chromosome (SMC) fa
— OG7
C4B63_351g1 ⚠
conserved hypothetical protein
— OG7
C4B63_7g236 ⚠
regulatory subunit of protein kinase a-like p
— OG7
C4B63_31g46 ⚠
structural maintenance of chromosome 3 protei
— OG7
C4B63_17g278 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_61g104
conserved hypothetical protein
— OG7
C4B63_2g828 ⚠
ankyrin repeat protein
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.