C4B63_124g1

phosphatidylinositol 3-kinase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_139742 OG7: OG7_0001934 371 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 371 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_10g280 ⚠
dihydrolipoamide dehydrogenase
— OG7
C4B63_326g15 ⚠
dihydrolipoamide dehydrogenase
— OG7
C4B63_249g22 ⚠
dihydrolipoamide dehydrogenase
— OG7
C4B63_249g23 ⚠
dihydrolipoamide dehydrogenase
— OG7
C4B63_358g1 ⚠
dihydrolipoamide dehydrogenase
— OG7
C4B63_326g16 ⚠
dihydrolipoamide dehydrogenase
— OG7
C4B63_23g143 ⚠
dihydrolipoamide dehydrogenase
— OG7
C4B63_40g114 ⚠
glycosyl hydrolase
— OG7
C4B63_13g334 ⚠
conserved hypothetical protein
— OG7
C4B63_80g31 ⚠
Dynein assembly factor 4, axonemal
— OG7
C4B63_28g113 ⚠
dynein arm light chain
— OG7
C4B63_41g138 ⚠
myotubularin
— OG7
C4B63_56g93 ⚠
Splicing factor 3B subunit 3
— OG7
C4B63_354g7 ⚠
damage-specific DNA binding protein
— OG7
C4B63_247g23 ⚠
damage-specific DNA binding protein
— OG7
C4B63_18g183 ⚠
damage-specific DNA binding protein
— OG7
C4B63_354g8 ⚠
damage-specific DNA binding protein
— OG7
C4B63_30g190 ⚠
60S ribosomal protein L23a
— OG7
C4B63_4g72 ⚠
fibrillarin
— OG7
C4B63_207g2 ⚠
fibrillarin
— OG7
C4B63_63g101 ⚠
Phosphatidylinositol 3-kinase tor1
— OG7
C4B63_57g88 ⚠
fibrillarin
— OG7
C4B63_22g113 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_124g2 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_34g361 ⚠
phosphatidylinositol kinase related protein
— OG7
C4B63_124g3 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_7g424 ⚠
phosphatidylinositol 3-kinase(fragment)
— OG7
C4B63_7g380 ⚠
phosphatidylinositol 3-kinase(fragment)
— OG7
C4B63_17g278 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_17g277 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_2g296 ⚠
AMP deaminase
— OG7
C4B63_14g249 ⚠
structural maintenance of chromosome 3
— +2 more OG7
C4B63_127g31 ⚠
Flagellum attachment zone protein 14
— OG7
C4B63_40g106 ⚠
Adaptor protein complex AP-3 subunit beta-3
— OG7
C4B63_63g32 ⚠
adaptin-related protein-like
— OG7
C4B63_72g101 ⚠
AMP deaminase(fragment)
— OG7
C4B63_2g735 ⚠
acyl transferase-like protein
— OG7
C4B63_14g87 ⚠
conserved hypothetical protein
— OG7
C4B63_14g103 ⚠
beta adaptin
— OG7
C4B63_168g31 ⚠
dynein arm light chain
— OG7
C4B63_6g572 ⚠
5'-3' exoribonuclease A
— OG7
C4B63_89g51 ⚠
FYVE zinc-finger containing protein
— OG7
C4B63_22g288 ⚠
Midasin
— OG7
C4B63_4g531 ⚠
Cleavage stimulation factor subunit 1
— OG7
C4B63_7g240 ⚠
ribosomal protein L3
— OG7
C4B63_12g196 ⚠
conserved hypothetical protein
— OG7
C4B63_25g220 ⚠
5'-3' exoribonuclease B
— OG7
C4B63_2g63 ⚠
conserved hypothetical protein
— OG7
C4B63_72g102 ⚠
adenosine monophosphate deaminase
— OG7
C4B63_7g397 ⚠
conserved hypothetical protein
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.