C4B63_40g106

Adaptor protein complex AP-3 subunit beta-3
Trypanosoma cruzi Dm28c 2018 OG6: OG6_101595 OG7: OG7_0001921 245 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 245 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_7g395 ⚠
conserved hypothetical protein
— Both
C4B63_11g484 ⚠
Leucine Rich Repeat protein
— OG7
C4B63_4g342 ⚠
ATP synthase mitochondrial F1 complex assembl
— OG7
C4B63_3g553 ⚠
NADH-dependent fumarate reductase
— OG7
C4B63_23g143 ⚠
dihydrolipoamide dehydrogenase
— OG7
C4B63_7g377 ⚠
[Pyruvate dehydrogenase (acetyl-transferring)
— OG7
C4B63_22g11 ⚠
developmentally regulated phosphoprotein
— OG7
C4B63_28g25 ⚠
pyruvate dehydrogenase (lipoamide) kinase
— OG7
C4B63_8g44 ⚠
conserved hypothetical protein
— OG7
C4B63_32g238 ⚠
tubulin folding cofactor D
— OG7
C4B63_32g239 ⚠
tubulin folding cofactor D
— OG7
C4B63_85g64 ⚠
DNA-damage inducible protein DDI1-like protei
— OG7
C4B63_21g30 ⚠
Exportin-7-A
— OG7
C4B63_24g190 ⚠
Exportin-7
— OG7
C4B63_38g67 ⚠
adenylate kinase
— OG7
C4B63_48g169 ⚠
adenylate kinase 1
— OG7
C4B63_192g4 ⚠
adenylate kinase 1
— OG7
C4B63_7g79 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_102g61 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_168g16 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_42g203 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_32g256 ⚠
PFU (PLAA family ubiquitin binding)
— OG7
C4B63_42g202 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_32g255 ⚠
WD domain, G-beta repeat
— OG7
C4B63_7g417 ⚠
snoRNP protein GAR1
— OG7
C4B63_124g1 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_17g277 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_17g278 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_7g424 ⚠
phosphatidylinositol 3-kinase(fragment)
— OG7
C4B63_124g3 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_34g361 ⚠
phosphatidylinositol kinase related protein
— OG7
C4B63_124g2 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_321g29 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_23g248 ⚠
inorganic pyrophosphatase
— OG7
C4B63_112g14 ⚠
neurobeachin/beige-like protein
— OG7
C4B63_160g6 ⚠
poly(A)-specific ribonuclease PARN
— OG7
C4B63_2g74 ⚠
poly(A)-specific ribonuclease PARN(fragment)
— OG7
C4B63_2g75 ⚠
poly(A)-specific ribonuclease PARN(fragment)
— OG7
C4B63_16g30 ⚠
poly(A)-specific ribonuclease PARN
— OG7
C4B63_63g95 ⚠
poly(A)-specific ribonuclease PARN
— OG7
C4B63_9g329 ⚠
Beige/BEACH domain
— OG7
C4B63_358g16 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_255g16 ⚠
RNA polymerase IIA largest subunit
— OG7
C4B63_48g124 ⚠
neurobeachin/beige protein
— OG7
C4B63_48g123 ⚠
neurobeachin/beige protein
— OG7
C4B63_70g77 ⚠
acidocalcisomal pyrophosphatase
— OG7
C4B63_9g327 ⚠
conserved hypothetical protein
— OG7
C4B63_259g8 ⚠
DNA polymerase theta (helicase domain only)
— OG7
C4B63_21g86 ⚠
conserved hypothetical protein
— OG7
C4B63_16g105 ⚠
coronin
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.