C4B63_70g77

acidocalcisomal pyrophosphatase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_100346 OG7: OG7_0003350 384 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 384 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_85g75 ⚠
ubiquitin activating enzyme
— OG7
C4B63_168g16 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_42g203 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_42g202 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_102g61 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_22g161 ⚠
calpain-like cysteine peptidase
— OG6
C4B63_7g79 ⚠
aspartyl-tRNA synthetase
— Both
C4B63_31g76 ⚠
ubiquitin-activating enzyme
— Both
C4B63_22g164 ⚠
calpain-like cysteine peptidase
— OG6
C4B63_149g26 ⚠
GDP-mannose pyrophosphorylase
— Both
C4B63_38g169 ⚠
calpain-like cysteine peptidase
— OG6
C4B63_4g146 ⚠
pyruvate kinase 2
— Both
C4B63_227g20 ⚠
pyruvate kinase 2
— Both
C4B63_4g213 ⚠
cyclophilin type peptidyl-prolyl cis-trans is
— OG6
C4B63_7g358 ⚠
conserved hypothetical protein
— Both
C4B63_175g8 ⚠
TPR-repeat protein
— OG6
C4B63_184g9 ⚠
protein phosphatase 2C
— OG6
C4B63_188g43 ⚠
conserved hypothetical protein
— Both
C4B63_11g25 ⚠
conserved hypothetical protein
— Both
C4B63_246g7 ⚠
Gastrulation defective protein 1 homolog
— Both
C4B63_20g213 ⚠
enoyl-CoA hydratase/isomerase family protein
— Both
C4B63_244g4 ⚠
Nuclear migration protein nudC
— Both
C4B63_14g17 ⚠
small G-protein
— OG6
C4B63_153g41 ⚠
inositol 5-phosphatase 1(fragment)
— Both
C4B63_21g30 ⚠
Exportin-7-A
— Both
C4B63_7g417 ⚠
snoRNP protein GAR1
— Both
C4B63_4g357 ⚠
Activator of 90 kDa heat shock protein ATPase
— Both
C4B63_4g375 ⚠
glucan 1,3-alpha-glucosidase
— Both
C4B63_35g191 ⚠
6-phosphogluconolactonase
— Both
C4B63_4g136 ⚠
N-myristoyl transferase
— Both
C4B63_44g235 ⚠
Kinesin-13 4
— OG7
C4B63_12g21 ⚠
Uncharacterized oxidoreductase YkwC
— OG7
C4B63_7g383 ⚠
epsilon-adaptin
— OG7
C4B63_87g11 ⚠
epsilon-adaptin(fragment)
— OG7
C4B63_88g55 ⚠
conserved hypothetical protein
— OG7
C4B63_20g217 ⚠
Methyltransferase tRNA wybutosine-synthesizin
— OG7
C4B63_175g10 ⚠
aldo/keto reductase
— OG7
C4B63_4g348 ⚠
Bifunctional coenzyme A synthase
— OG7
C4B63_2g450 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_46g15 ⚠
Kinesin-13 5
— OG7
C4B63_325g1 ⚠
Kinesin-13 1
— OG7
C4B63_69g61 ⚠
Kinesin-13 1
— OG7
C4B63_23g109 ⚠
UDP-glucose:glycoprotein glucosyltransferase
— Both
C4B63_4g214 ⚠
cyclophilin type peptidyl-prolyl cis-trans is
— OG6
C4B63_3g1104 ⚠
threonyl-tRNA synthetase
— Both
C4B63_54g22 ⚠
conserved hypothetical protein
— Both
C4B63_27g4 ⚠
ubiquitin ligase
— Both
C4B63_2g748 ⚠
conserved hypothetical protein
— Both
C4B63_32g239 ⚠
tubulin folding cofactor D
— Both
C4B63_144g30 ⚠
Kinesin-13 1
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.