C4B63_70g77

acidocalcisomal pyrophosphatase

Trypanosoma cruzi Dm28c 2018 OG6: OG6_100346 OG7: OG7_0003350 384 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 384 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_85g75 ⚠ ubiquitin activating enzyme	—	OG7 Tb927.11.7060 ↔ Tb927.5.3430 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_010542	OG7
C4B63_168g16 ⚠ aspartyl-tRNA synthetase	—	OG7 Tb927.11.7060 ↔ Tb927.4.2310 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003867	OG7
C4B63_42g203 ⚠ aspartyl-tRNA synthetase	—	OG7 Tb927.11.7060 ↔ Tb927.4.2310 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003867	OG7
C4B63_42g202 ⚠ aspartyl-tRNA synthetase	—	OG7 Tb927.11.7060 ↔ Tb927.4.2310 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003867	OG7
C4B63_102g61 ⚠ aspartyl-tRNA synthetase	—	OG7 Tb927.11.7060 ↔ Tb927.4.2310 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003867	OG7
C4B63_22g161 ⚠ calpain-like cysteine peptidase	—	OG6 Tb927.11.7060 ↔ Tb927.9.7540 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007342	OG6
C4B63_7g79 ⚠ aspartyl-tRNA synthetase	—	OG6 Tb927.11.7060 ↔ Tb927.4.2310 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003867 OG7 Tb927.11.7060 ↔ Tb927.4.2310 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003867	Both
C4B63_31g76 ⚠ ubiquitin-activating enzyme	—	OG6 Tb927.11.7060 ↔ Tb927.5.3430 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_010542 OG7 Tb927.11.7060 ↔ Tb927.5.3430 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_010542	Both
C4B63_22g164 ⚠ calpain-like cysteine peptidase	—	OG6 Tb927.11.7060 ↔ Tb927.9.7540 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007342	OG6
C4B63_149g26 ⚠ GDP-mannose pyrophosphorylase	—	OG6 Tb927.11.7080 ↔ Tb927.8.2050 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007603 OG7 Tb927.11.7080 ↔ Tb927.8.2050 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007603	Both
C4B63_38g169 ⚠ calpain-like cysteine peptidase	—	OG6 Tb927.11.7060 ↔ Tb927.9.7540 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007342	OG6
C4B63_4g146 ⚠ pyruvate kinase 2	—	OG6 Tb927.10.14140 ↔ Tb927.11.7060 OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006133 OG7 Tb927.10.14140 ↔ Tb927.11.7060 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006133	Both
C4B63_227g20 ⚠ pyruvate kinase 2	—	OG6 Tb927.10.14140 ↔ Tb927.11.7060 OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006133 OG7 Tb927.10.14140 ↔ Tb927.11.7060 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006133	Both
C4B63_4g213 ⚠ cyclophilin type peptidyl-prolyl cis-trans is	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006217	OG6
C4B63_7g358 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003737 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003737	Both
C4B63_175g8 ⚠ TPR-repeat protein	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_009926 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003496	OG6
C4B63_184g9 ⚠ protein phosphatase 2C	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_007482	OG6
C4B63_188g43 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_009863 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_009863	Both
C4B63_11g25 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006390 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006390	Both
C4B63_246g7 ⚠ Gastrulation defective protein 1 homolog	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_004877 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_004877	Both
C4B63_20g213 ⚠ enoyl-CoA hydratase/isomerase family protein	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_005344 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_005344	Both
C4B63_244g4 ⚠ Nuclear migration protein nudC	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_010327 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_010327	Both
C4B63_14g17 ⚠ small G-protein	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_004644	OG6
C4B63_153g41 ⚠ inositol 5-phosphatase 1(fragment)	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007569	Both
C4B63_21g30 ⚠ Exportin-7-A	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003586 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003586	Both
C4B63_7g417 ⚠ snoRNP protein GAR1	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_003690 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_003690	Both
C4B63_4g357 ⚠ Activator of 90 kDa heat shock protein ATPase	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006151 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006151	Both
C4B63_4g375 ⚠ glucan 1,3-alpha-glucosidase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006140 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006141	Both
C4B63_35g191 ⚠ 6-phosphogluconolactonase	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_007658 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_007658	Both
C4B63_4g136 ⚠ N-myristoyl transferase	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006126 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006126	Both
C4B63_44g235 ⚠ Kinesin-13 4	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7
C4B63_12g21 ⚠ Uncharacterized oxidoreductase YkwC	—	OG7 TCSYLVIO_003074 ↔ TCSYLVIO_004455	OG7
C4B63_7g383 ⚠ epsilon-adaptin	—	OG7 TCSYLVIO_003203 ↔ TCSYLVIO_004455	OG7
C4B63_87g11 ⚠ epsilon-adaptin(fragment)	—	OG7 TCSYLVIO_003203 ↔ TCSYLVIO_004455	OG7
C4B63_88g55 ⚠ conserved hypothetical protein	—	OG7 Tb927.11.12670 ↔ Tb927.11.7080	OG7
C4B63_20g217 ⚠ Methyltransferase tRNA wybutosine-synthesizin	—	OG7 Tb927.11.12670 ↔ Tb927.11.7080	OG7
C4B63_175g10 ⚠ aldo/keto reductase	—	OG7 TCSYLVIO_001508 ↔ TCSYLVIO_004455	OG7
C4B63_4g348 ⚠ Bifunctional coenzyme A synthase	—	OG7 TCSYLVIO_004096 ↔ TCSYLVIO_004455	OG7
C4B63_2g450 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_001709	OG7
C4B63_46g15 ⚠ Kinesin-13 5	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7
C4B63_325g1 ⚠ Kinesin-13 1	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7
C4B63_69g61 ⚠ Kinesin-13 1	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7
C4B63_23g109 ⚠ UDP-glucose:glycoprotein glucosyltransferase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_004363 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_004363	Both
C4B63_4g214 ⚠ cyclophilin type peptidyl-prolyl cis-trans is	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006217	OG6
C4B63_3g1104 ⚠ threonyl-tRNA synthetase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007511 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007511	Both
C4B63_54g22 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_005080 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_005080	Both
C4B63_27g4 ⚠ ubiquitin ligase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_006542 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_006542	Both
C4B63_2g748 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_005810 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_005810	Both
C4B63_32g239 ⚠ tubulin folding cofactor D	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_001709 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001709	Both
C4B63_144g30 ⚠ Kinesin-13 1	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_004455	OG7

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