C4B63_149g26

GDP-mannose pyrophosphorylase

Trypanosoma cruzi Dm28c 2018 OG6: OG6_100460 OG7: OG7_0001668 255 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 255 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_30g161 ⚠ glutamine synthetase	—	OG6 Tb927.7.4970 ↔ Tb927.8.2050 OG6 TCSYLVIO_001811 ↔ TCSYLVIO_007603 OG7 Tb927.7.4970 ↔ Tb927.8.2050 OG7 TCSYLVIO_001811 ↔ TCSYLVIO_007603	Both
C4B63_143g20 ⚠ glutamine synthetase	—	OG6 Tb927.7.4970 ↔ Tb927.8.2050 OG6 TCSYLVIO_001811 ↔ TCSYLVIO_007603 OG7 Tb927.7.4970 ↔ Tb927.8.2050 OG7 TCSYLVIO_001811 ↔ TCSYLVIO_007603	Both
C4B63_70g77 ⚠ acidocalcisomal pyrophosphatase	—	OG6 Tb927.11.7080 ↔ Tb927.8.2050 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007603 OG7 Tb927.11.7080 ↔ Tb927.8.2050 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007603	Both
C4B63_23g248 ⚠ inorganic pyrophosphatase	—	OG6 Tb927.11.7080 ↔ Tb927.8.2050 OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007603 OG7 Tb927.11.7080 ↔ Tb927.8.2050 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007603	Both
C4B63_101g36 ⚠ inositol-3-phosphate synthase	—	OG6 TCSYLVIO_007453 ↔ TCSYLVIO_007603 OG6 Tb927.10.7110 ↔ Tb927.8.2050 OG7 Tb927.10.7110 ↔ Tb927.8.2050 OG7 TCSYLVIO_007453 ↔ TCSYLVIO_007603	Both
C4B63_355g19 ⚠ inositol-3-phosphate synthase(fragment)	—	OG6 TCSYLVIO_007453 ↔ TCSYLVIO_007603 OG6 Tb927.10.7110 ↔ Tb927.8.2050 OG7 Tb927.10.7110 ↔ Tb927.8.2050 OG7 TCSYLVIO_007453 ↔ TCSYLVIO_007603	Both
C4B63_41g128 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007603	OG7
C4B63_160g6 ⚠ poly(A)-specific ribonuclease PARN	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007603	Both
C4B63_224g16 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007603	OG7
C4B63_41g122 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007603	OG7
C4B63_41g125 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007603	OG7
C4B63_43g202 ⚠ hook complex protein, conserved	—	OG7 TCSYLVIO_005619 ↔ TCSYLVIO_007603	OG7
C4B63_41g119 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007603	OG7
C4B63_348g23 ⚠ cytochrome b5	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007603	OG7
C4B63_25g1526c ⚠ Acyl-lipid (8-3)-desaturase	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007603	OG7
C4B63_10g403 ⚠ cytochrome b5	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007603	OG7
C4B63_8g211 ⚠ cytochrome b	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007603	OG7
C4B63_1g121c ⚠ cytochrome b5-like protein	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007603	OG7
C4B63_70g572c ⚠ cytochrome b5	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007603	OG7
C4B63_7g306 ⚠ cleavage and polyadenylation specificity fact	—	OG7 TCSYLVIO_005414 ↔ TCSYLVIO_007603	OG7
C4B63_34g372 ⚠ cytochrome b-domain protein	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007603	OG7
C4B63_2g450 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_007603	OG7
C4B63_72g106 ⚠ DIS3-like exonuclease(fragment)	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007603	OG7
C4B63_276g11 ⚠ DIS3-like exonuclease(fragment)	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007603	OG7
C4B63_30g129 ⚠ rrp44p homologue	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007603	OG7
C4B63_268g24 ⚠ HSPBP1	—	OG6 TCSYLVIO_003958 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_003958 ↔ TCSYLVIO_007603	Both
C4B63_20g355 ⚠ HSPBP1	—	OG6 TCSYLVIO_003958 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_003958 ↔ TCSYLVIO_007603	Both
C4B63_32g238 ⚠ tubulin folding cofactor D	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_007603	Both
C4B63_32g239 ⚠ tubulin folding cofactor D	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_007603	Both
C4B63_42g187 conserved hypothetical protein	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_007603	Both
C4B63_27g4 ⚠ ubiquitin ligase	—	OG6 TCSYLVIO_006542 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_006542 ↔ TCSYLVIO_007603	Both
C4B63_10g517 ⚠ tryptophanyl-tRNA synthetase	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010724	OG6
C4B63_244g4 ⚠ Nuclear migration protein nudC	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010327 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010327	Both
C4B63_82g71 ⚠ tryptophanyl-tRNA synthetase	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010724	OG6
C4B63_13g161 conserved hypothetical protein	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009932 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_009932	Both
C4B63_61g23 ⚠ tRNA-dihydrouridine synthase 3	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_009102	Both
C4B63_52g161 ⚠ tyrosyl-tRNA synthetase	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_010624	Both
C4B63_56g85 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001973 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_007603	Both
C4B63_14g155 Leucine-rich repeat-containing protein 74A	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_007603	Both
C4B63_54g57 vacuolar ATP synthase subunit d	—	OG6 TCSYLVIO_005104 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_005104 ↔ TCSYLVIO_007603	Both
C4B63_11g484 Leucine Rich Repeat protein	—	OG6 TCSYLVIO_006421 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_006421 ↔ TCSYLVIO_007603	Both
C4B63_14g96 ⚠ isoleucil-tRNA synthetase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007603	Both
C4B63_14g97 ⚠ isoleucyl-tRNA synthetase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007603	Both
C4B63_21g30 ⚠ Exportin-7-A	—	OG6 TCSYLVIO_003586 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_003586 ↔ TCSYLVIO_007603	Both
C4B63_24g190 ⚠ Exportin-7	—	OG6 TCSYLVIO_003586 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_003586 ↔ TCSYLVIO_007603	Both
C4B63_22g11 ⚠ developmentally regulated phosphoprotein	—	OG6 TCSYLVIO_007262 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007603	Both
C4B63_58g38 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_006877 ↔ TCSYLVIO_007603	OG7
C4B63_16g30 ⚠ poly(A)-specific ribonuclease PARN	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007603	Both
C4B63_63g95 ⚠ poly(A)-specific ribonuclease PARN	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007603	Both
C4B63_34g118 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_000836 ↔ TCSYLVIO_007603 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_007603	Both

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