C4B63_101g36

inositol-3-phosphate synthase

Trypanosoma cruzi Dm28c 2018 OG6: OG6_100830 OG7: OG7_0006574 250 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 250 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_12g220 ⚠ pyruvate phosphate dikinase	—	OG6 LdBPK_111000.1 ↔ LdBPK_141450.1 OG6 Tb927.10.7110 ↔ Tb927.11.6280 OG7 Tb927.10.7110 ↔ Tb927.11.6280 OG7 LdBPK_111000.1 ↔ LdBPK_141450.1	Both
C4B63_12g221 ⚠ pyruvate phosphate dikinase	—	OG6 LdBPK_111000.1 ↔ LdBPK_141450.1 OG6 Tb927.10.7110 ↔ Tb927.11.6280 OG7 Tb927.10.7110 ↔ Tb927.11.6280 OG7 LdBPK_111000.1 ↔ LdBPK_141450.1	Both
C4B63_2g244 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005710 ↔ TCSYLVIO_007453 OG6 LdBPK_141450.1 ↔ LdBPK_354620.1 OG7 LdBPK_141450.1 ↔ LdBPK_354620.1 OG7 TCSYLVIO_005710 ↔ TCSYLVIO_007453	Both
C4B63_2g243 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005710 ↔ TCSYLVIO_007453 OG6 LdBPK_141450.1 ↔ LdBPK_354620.1 OG7 LdBPK_141450.1 ↔ LdBPK_354620.1 OG7 TCSYLVIO_005710 ↔ TCSYLVIO_007453	Both
C4B63_4g502 ⚠ ABC transporter	—	OG6 TCSYLVIO_006012 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_006012 ↔ TCSYLVIO_007453 OG7 LdBPK_141450.1 ↔ LdBPK_330340.1	Both
C4B63_113g34 ⚠ ABC transporter	—	OG6 LdBPK_141450.1 ↔ LdBPK_330340.1 OG7 TCSYLVIO_006012 ↔ TCSYLVIO_007453 OG7 LdBPK_141450.1 ↔ LdBPK_330340.1	Both
C4B63_206g11 ⚠ ABC transporter	—	OG7 TCSYLVIO_006012 ↔ TCSYLVIO_007453 OG7 LdBPK_141450.1 ↔ LdBPK_330340.1	OG7
C4B63_47g107 ⚠ ABC transporter	—	OG7 TCSYLVIO_006012 ↔ TCSYLVIO_007453 OG7 LdBPK_141450.1 ↔ LdBPK_330340.1	OG7
C4B63_149g26 ⚠ GDP-mannose pyrophosphorylase	—	OG6 TCSYLVIO_007453 ↔ TCSYLVIO_007603 OG6 Tb927.10.7110 ↔ Tb927.8.2050 OG7 Tb927.10.7110 ↔ Tb927.8.2050 OG7 TCSYLVIO_007453 ↔ TCSYLVIO_007603	Both
C4B63_19g179 ⚠ protein kinase	—	OG6 TCSYLVIO_007401 ↔ TCSYLVIO_007453 OG7 LdBPK_141450.1 ↔ LdBPK_331490.1 OG7 TCSYLVIO_007401 ↔ TCSYLVIO_007453	Both
C4B63_6g521 ⚠ DIS3-like exonuclease	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_007453 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007453 +1 more	Both
C4B63_72g106 ⚠ DIS3-like exonuclease(fragment)	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007453 OG7 LdBPK_141450.1 ↔ LdBPK_280470.1	OG7
C4B63_276g11 ⚠ DIS3-like exonuclease(fragment)	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007453 OG7 LdBPK_141450.1 ↔ LdBPK_280470.1	OG7
C4B63_30g129 ⚠ rrp44p homologue	—	OG6 LdBPK_141450.1 ↔ LdBPK_280470.1 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007453 OG7 LdBPK_141450.1 ↔ LdBPK_280470.1	Both
C4B63_14g96 ⚠ isoleucil-tRNA synthetase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007453	Both
C4B63_42g216 ⚠ disgorgin	—	OG7 TCSYLVIO_004663 ↔ TCSYLVIO_007453	OG7
C4B63_95g32 ⚠ conserved hypothetical protein	—	OG7 LdBPK_130770.1 ↔ LdBPK_141450.1	OG7
C4B63_40g73 ⚠ glycosyl hydrolase-like protein	—	OG7 TCSYLVIO_006140 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_007453	OG7
C4B63_3g864 ⚠ Mucin-associated surface protein (MASP)	—	OG7 TCSYLVIO_002771 ↔ TCSYLVIO_007453	OG7
C4B63_2g431 ⚠ GTPase protein	—	OG7 LdBPK_050200.1 ↔ LdBPK_141450.1	OG7
C4B63_2g345 ⚠ GTP-binding protein	—	OG7 LdBPK_050200.1 ↔ LdBPK_141450.1	OG7
C4B63_91g35 ⚠ GTPase	—	OG7 LdBPK_050200.1 ↔ LdBPK_141450.1	OG7
C4B63_8g202 ⚠ GTP-binding protein	—	OG7 LdBPK_050200.1 ↔ LdBPK_141450.1	OG7
C4B63_56g32 ⚠ GTPase	—	OG7 LdBPK_050200.1 ↔ LdBPK_141450.1	OG7
C4B63_348g23 ⚠ cytochrome b5	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007453	OG7
C4B63_25g1526c ⚠ Acyl-lipid (8-3)-desaturase	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007453	OG7
C4B63_10g403 ⚠ cytochrome b5	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007453	OG7
C4B63_8g211 ⚠ cytochrome b	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007453	OG7
C4B63_1g121c ⚠ cytochrome b5-like protein	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007453	OG7
C4B63_70g572c ⚠ cytochrome b5	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007453	OG7
C4B63_7g306 ⚠ cleavage and polyadenylation specificity fact	—	OG7 TCSYLVIO_005414 ↔ TCSYLVIO_007453	OG7
C4B63_34g372 ⚠ cytochrome b-domain protein	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007453	OG7
C4B63_61g73 ⚠ Acyl-CoA-binding domain-containing protein 5	—	OG7 LdBPK_090800.1 ↔ LdBPK_141450.1	OG7
C4B63_109g69 ⚠ Acyl-CoA-binding domain-containing protein 4	—	OG7 LdBPK_090800.1 ↔ LdBPK_141450.1	OG7
C4B63_7g1820c ⚠ acyl-CoA binding protein	—	OG7 LdBPK_090800.1 ↔ LdBPK_141450.1	OG7
C4B63_34g156 ⚠ Acyl-CoA-binding domain-containing protein 4	—	OG7 LdBPK_090800.1 ↔ LdBPK_141450.1	OG7
C4B63_25g968c ⚠ Acyl-CoA-binding domain-containing protein 5	—	OG7 LdBPK_090800.1 ↔ LdBPK_141450.1	OG7
C4B63_181g13 ⚠ conserved hypothetical protein	—	OG7 LdBPK_090800.1 ↔ LdBPK_141450.1	OG7
C4B63_18g130 ⚠ glutamyl-tRNA synthetase	—	OG7 Tb927.10.7110 ↔ Tb927.9.5210	OG7
C4B63_11g9 ⚠ eukaryotic translation initiation factor 3 su	—	OG6 TCSYLVIO_006404 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_006404 ↔ TCSYLVIO_007453	Both
C4B63_13g167 ⚠ stress-inducible protein STI1-like	—	OG6 TCSYLVIO_003496 ↔ TCSYLVIO_007453	OG6
C4B63_184g38 ⚠ TPR-repeat protein	—	OG6 TCSYLVIO_003496 ↔ TCSYLVIO_007453	OG6
C4B63_54g28 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005084 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_005084 ↔ TCSYLVIO_007453	Both
C4B63_81g44 ⚠ tRNA (cytosine(34)-C(5))-methyltransferase	—	OG6 TCSYLVIO_004998 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_004998 ↔ TCSYLVIO_007453	Both
C4B63_23g207 ⚠ tRNA (cytosine(34)-C(5))-methyltransferase	—	OG6 TCSYLVIO_004998 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_004998 ↔ TCSYLVIO_007453	Both
C4B63_4g375 ⚠ glucan 1,3-alpha-glucosidase	—	OG6 TCSYLVIO_006140 ↔ TCSYLVIO_007453 OG6 TCSYLVIO_006141 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_007453	Both
C4B63_227g2 ⚠ glucan 1,3-alpha-glucosidase	—	OG6 TCSYLVIO_006140 ↔ TCSYLVIO_007453 OG6 TCSYLVIO_006141 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_007453	Both
C4B63_18g219 ⚠ tRNA methyltransferase 10 homolog A	—	OG6 LdBPK_141450.1 ↔ LdBPK_303110.1 OG7 LdBPK_141450.1 ↔ LdBPK_303110.1	Both
C4B63_32g257 ⚠ Cyclin-U3-1	—	OG6 LdBPK_141450.1 ↔ LdBPK_241960.1 OG7 LdBPK_141450.1 ↔ LdBPK_241960.1	Both
C4B63_8g522 ⚠ conserved hypothetical protein	—	OG6 LdBPK_141450.1 ↔ LdBPK_260460.1 OG7 LdBPK_141450.1 ↔ LdBPK_260460.1	Both

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