C4B63_6g521

DIS3-like exonuclease

Trypanosoma cruzi Dm28c 2018 OG6: OG6_102526 OG7: OG7_0002439 305 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 305 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_101g36 ⚠ inositol-3-phosphate synthase	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_007453 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007453 +1 more	Both
C4B63_136g36 ⚠ Alanyl-tRNA editing protein Aarsd1	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_007097 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007097 OG7 LdBPK_150720.1 ↔ LdBPK_280470.1	Both
C4B63_2g450 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 +1 more	Both
C4B63_93g65 ⚠ amidohydrolase	—	OG6 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 OG7 LdBPK_201740.1 ↔ LdBPK_280470.1	Both
C4B63_26g317 ⚠ Alanyl-tRNA editing protein Aarsd1-B	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_007097 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007097 OG7 LdBPK_150720.1 ↔ LdBPK_280470.1	Both
C4B63_2g244 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_005710 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_005710 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_005710 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005710 +1 more	Both
C4B63_136g37 ⚠ tRNA synthetases class II (A)/Threonyl and Al	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_007097 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007097 OG7 LdBPK_150720.1 ↔ LdBPK_280470.1	Both
C4B63_2g243 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_005710 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_005710 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_005710 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005710 +1 more	Both
C4B63_193g9 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 OG7 LdBPK_110640.1 ↔ LdBPK_280470.1	OG7
C4B63_93g64 ⚠ amidohydrolase	—	OG6 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_008414 OG7 LdBPK_201720.1 ↔ LdBPK_280470.1 OG7 LdBPK_201740.1 ↔ LdBPK_280470.1	Both
C4B63_19g179 ⚠ protein kinase	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_007401 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_007401 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007401 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007401 +1 more	Both
C4B63_355g19 ⚠ inositol-3-phosphate synthase(fragment)	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_007453 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007453 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007453 +1 more	Both
C4B63_70g129 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 OG7 LdBPK_110640.1 ↔ LdBPK_280470.1	OG7
C4B63_12g153 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 OG7 LdBPK_110640.1 ↔ LdBPK_280470.1	OG7
C4B63_40g73 ⚠ glycosyl hydrolase-like protein	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_006141 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_006140 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_006141	OG7
C4B63_20g12 ⚠ Vacuolar protein sorting-associated protein 2	—	OG7 LdBPK_280470.1 ↔ LdBPK_341570.1	OG7
C4B63_14g19 ⚠ flagellum transition zone component	—	OG7 LdBPK_280470.1 ↔ LdBPK_366480.1	OG7
C4B63_24g246 ⚠ kynureninase	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_003624	OG7
C4B63_348g23 ⚠ cytochrome b5	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_003124 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003124	OG7
C4B63_102g71 ⚠ Programmed cell death protein 2, C-terminal d	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_008261	OG7
C4B63_294g18 ⚠ dihydrouridine synthase (Dus)	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_009102	OG7
C4B63_42g172 ⚠ nuclear movement protein	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_010327 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_010327	OG7
C4B63_13g41 ⚠ protein kinase	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004355	OG7
C4B63_25g1526c ⚠ Acyl-lipid (8-3)-desaturase	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_003124 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003124	OG7
C4B63_263g16 ⚠ Programmed cell death protein 2-like	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_008261	OG7
C4B63_297g16 ⚠ cholinephosphate cytidylyltransferase A	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_004212	OG7
C4B63_6g391 ⚠ protein kinase	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004355	OG7
C4B63_87g16 ⚠ pitrilysin-like metalloprotease	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_009816	OG7
C4B63_7g306 ⚠ cleavage and polyadenylation specificity fact	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_005414 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005414	OG7
C4B63_58g38 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_006877 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_006877	OG7
C4B63_148g30 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_004123	OG7
C4B63_54g35 ⚠ protein kinase	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004355	OG7
C4B63_76g131 ⚠ protein kinase	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004355	OG7
C4B63_63g95 ⚠ poly(A)-specific ribonuclease PARN	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_004635	OG7
C4B63_10g403 ⚠ cytochrome b5	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_003124 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_003124	OG7
C4B63_20g6 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_011102	OG7
C4B63_13g118 ⚠ tRNA-dihydrouridine synthase 2	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_009102	OG7
C4B63_20g51 ⚠ tRNA-dihydrouridine synthase 4	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_009102	OG7
C4B63_336g10 ⚠ dihydrouridine synthase (Dus)	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_009102 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_009102	OG7
C4B63_2g785 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_005838	OG7
C4B63_7g161 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_011102	OG7
C4B63_7g169 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_011102	OG7
C4B63_7g173 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_011102	OG7
C4B63_7g324 ⚠ Programmed cell death protein 2, C-terminal d	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_008261	OG7
C4B63_45g139 ⚠ serine/threonine protein kinase	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004355	OG7
C4B63_18g248 ⚠ GTPase activating protein of Rab-like GTPase	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_008881	OG7
C4B63_4g180 ⚠ serine/threonine protein kinase	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_004355	OG7
C4B63_8g494 ⚠ Protein ApaG	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_002337	OG7
C4B63_147g45 ⚠ kynureninase	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_003624	OG7
C4B63_2g362 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_005630	OG7

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