C4B63_6g521

DIS3-like exonuclease
Trypanosoma cruzi Dm28c 2018 OG6: OG6_102526 OG7: OG7_0002439 305 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 305 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_101g36 ⚠
inositol-3-phosphate synthase
— +1 more Both
C4B63_136g36 ⚠
Alanyl-tRNA editing protein Aarsd1
— Both
C4B63_2g450 ⚠
metallo-peptidase, Clan MF, Family M17
— +1 more Both
C4B63_93g65 ⚠
amidohydrolase
— Both
C4B63_26g317 ⚠
Alanyl-tRNA editing protein Aarsd1-B
— Both
C4B63_2g244 ⚠
conserved hypothetical protein
— +1 more Both
C4B63_136g37 ⚠
tRNA synthetases class II (A)/Threonyl and Al
— Both
C4B63_2g243 ⚠
conserved hypothetical protein
— +1 more Both
C4B63_193g9 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_93g64 ⚠
amidohydrolase
— Both
C4B63_19g179 ⚠
protein kinase
— +1 more Both
C4B63_355g19 ⚠
inositol-3-phosphate synthase(fragment)
— +1 more Both
C4B63_70g129 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_12g153 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_40g73 ⚠
glycosyl hydrolase-like protein
— OG7
C4B63_20g12 ⚠
Vacuolar protein sorting-associated protein 2
— OG7
C4B63_14g19 ⚠
flagellum transition zone component
— OG7
C4B63_24g246 ⚠
kynureninase
— OG7
C4B63_348g23 ⚠
cytochrome b5
— OG7
C4B63_102g71 ⚠
Programmed cell death protein 2, C-terminal d
— OG7
C4B63_294g18 ⚠
dihydrouridine synthase (Dus)
— OG7
C4B63_42g172 ⚠
nuclear movement protein
— OG7
C4B63_13g41 ⚠
protein kinase
— OG7
C4B63_25g1526c ⚠
Acyl-lipid (8-3)-desaturase
— OG7
C4B63_263g16 ⚠
Programmed cell death protein 2-like
— OG7
C4B63_297g16 ⚠
cholinephosphate cytidylyltransferase A
— OG7
C4B63_6g391 ⚠
protein kinase
— OG7
C4B63_87g16 ⚠
pitrilysin-like metalloprotease
— OG7
C4B63_7g306 ⚠
cleavage and polyadenylation specificity fact
— OG7
C4B63_58g38 ⚠
conserved hypothetical protein
— OG7
C4B63_148g30 ⚠
conserved hypothetical protein
— OG7
C4B63_54g35 ⚠
protein kinase
— OG7
C4B63_76g131 ⚠
protein kinase
— OG7
C4B63_63g95 ⚠
poly(A)-specific ribonuclease PARN
— OG7
C4B63_10g403 ⚠
cytochrome b5
— OG7
C4B63_20g6 ⚠
D-isomer specific 2-hydroxyacid dehydrogenase
— OG7
C4B63_13g118 ⚠
tRNA-dihydrouridine synthase 2
— OG7
C4B63_20g51 ⚠
tRNA-dihydrouridine synthase 4
— OG7
C4B63_336g10 ⚠
dihydrouridine synthase (Dus)
— OG7
C4B63_2g785 ⚠
conserved hypothetical protein
— OG7
C4B63_7g161 ⚠
D-isomer specific 2-hydroxyacid dehydrogenase
— OG7
C4B63_7g169 ⚠
D-isomer specific 2-hydroxyacid dehydrogenase
— OG7
C4B63_7g173 ⚠
D-isomer specific 2-hydroxyacid dehydrogenase
— OG7
C4B63_7g324 ⚠
Programmed cell death protein 2, C-terminal d
— OG7
C4B63_45g139 ⚠
serine/threonine protein kinase
— OG7
C4B63_18g248 ⚠
GTPase activating protein of Rab-like GTPase
— OG7
C4B63_4g180 ⚠
serine/threonine protein kinase
— OG7
C4B63_8g494 ⚠
Protein ApaG
— OG7
C4B63_147g45 ⚠
kynureninase
— OG7
C4B63_2g362 ⚠
conserved hypothetical protein
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.