C4B63_2g450

metallo-peptidase, Clan MF, Family M17

Trypanosoma cruzi Dm28c 2018 OG6: OG6_105603 OG7: OG7_0003405 328 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 328 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_93g65 ⚠ amidohydrolase	—	OG6 TCSYLVIO_005560 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_332700.1 OG6 LdBPK_201740.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008414 +7 more	Both
C4B63_93g64 ⚠ amidohydrolase	—	OG6 TCSYLVIO_005560 ↔ TCSYLVIO_008414 OG6 LdBPK_201720.1 ↔ LdBPK_332700.1 OG6 LdBPK_201740.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008414 +7 more	Both
C4B63_30g129 ⚠ rrp44p homologue	—	OG6 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 +1 more	Both
C4B63_72g106 ⚠ DIS3-like exonuclease(fragment)	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 OG7 LdBPK_110640.1 ↔ LdBPK_280470.1	OG7
C4B63_276g11 ⚠ DIS3-like exonuclease(fragment)	—	OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 OG7 LdBPK_110640.1 ↔ LdBPK_280470.1	OG7
C4B63_15g18 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
C4B63_3g552 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
C4B63_85g64 ⚠ DNA-damage inducible protein DDI1-like protei	—	OG6 LdBPK_010630.1 ↔ LdBPK_332700.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003428 OG7 LdBPK_010630.1 ↔ LdBPK_110630.1 OG7 LdBPK_010630.1 ↔ LdBPK_332700.1 +1 more	Both
C4B63_3g553 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
C4B63_42g187 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG7 LdBPK_110640.1 ↔ LdBPK_300580.1	OG7
C4B63_3g550 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
C4B63_168g16 ⚠ aspartyl-tRNA synthetase	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_005560 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	Both
C4B63_42g203 ⚠ aspartyl-tRNA synthetase	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_005560 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	Both
C4B63_54g71 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
C4B63_42g202 ⚠ aspartyl-tRNA synthetase	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_005560 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	Both
C4B63_102g61 ⚠ aspartyl-tRNA synthetase	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_005560 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	Both
C4B63_42g49 ⚠ Protein aardvark	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003145 OG7 LdBPK_110630.1 ↔ LdBPK_300810.1	OG7
C4B63_14g96 ⚠ isoleucil-tRNA synthetase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005560 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
C4B63_15g19 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
C4B63_14g97 ⚠ isoleucyl-tRNA synthetase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_005560 OG7 LdBPK_110630.1 ↔ LdBPK_365870.1 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_005560	Both
C4B63_3g554 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
C4B63_3g551 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
C4B63_40g52 ⚠ conserved hypothetical protein	—	OG6 LdBPK_332700.1 ↔ LdBPK_364240.1 OG6 TCSYLVIO_005560 ↔ TCSYLVIO_008197 OG7 TCSYLVIO_005560 ↔ TCSYLVIO_008197 OG7 LdBPK_110630.1 ↔ LdBPK_364240.1 +2 more	Both
C4B63_6g521 ⚠ DIS3-like exonuclease	—	OG6 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_005560 OG7 LdBPK_280470.1 ↔ LdBPK_332700.1 OG7 LdBPK_110630.1 ↔ LdBPK_280470.1 +1 more	Both
C4B63_54g70 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_008502 OG7 LdBPK_110630.1 ↔ LdBPK_350850.1	OG7
C4B63_31g99 ⚠ WD repeat-containing protein 17	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_110640.1	OG7
C4B63_7g79 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003867 OG7 LdBPK_110640.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_005560	OG7
C4B63_92g114 ⚠ conserved hypothetical protein	—	OG7 LdBPK_110640.1 ↔ LdBPK_310320.1	OG7
C4B63_26g231 ⚠ ubiquitin hydrolase(fragment)	—	OG7 LdBPK_332700.1 ↔ LdBPK_343890.1	OG7
C4B63_4g181 ⚠ Sestrin-3	—	OG7 LdBPK_110630.1 ↔ LdBPK_180660.1	OG7
C4B63_6g400 ⚠ conserved hypothetical protein	—	OG7 LdBPK_110640.1 ↔ LdBPK_282030.1	OG7
C4B63_2g815 ⚠ conserved hypothetical protein	—	OG7 LdBPK_110640.1 ↔ LdBPK_352820.1	OG7
C4B63_83g79 ⚠ RNA pseudouridylate synthase	—	OG7 LdBPK_110630.1 ↔ LdBPK_261140.1 OG7 LdBPK_110640.1 ↔ LdBPK_261140.1 OG7 LdBPK_261140.1 ↔ LdBPK_332700.1	OG7
C4B63_297g7 ⚠ CYC2-like cyclin(fragment)	—	OG7 LdBPK_110630.1 ↔ LdBPK_241960.1 OG7 LdBPK_110640.1 ↔ LdBPK_241960.1 OG7 LdBPK_241960.1 ↔ LdBPK_332700.1	OG7
C4B63_206g3 ⚠ tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminoc	—	OG7 LdBPK_110630.1 ↔ LdBPK_160320.1 OG7 LdBPK_110640.1 ↔ LdBPK_160320.1 OG7 LdBPK_160320.1 ↔ LdBPK_332700.1	OG7
C4B63_171g30 ⚠ FK506-binding protein (FKBP)-type peptidyl-pr	—	OG7 LdBPK_110630.1 ↔ LdBPK_291330.1 OG7 LdBPK_110640.1 ↔ LdBPK_291330.1 OG7 LdBPK_291330.1 ↔ LdBPK_332700.1	OG7
C4B63_488g7 ⚠ conserved hypothetical protein	—	OG7 LdBPK_110640.1 ↔ LdBPK_310320.1	OG7
C4B63_157g32 ⚠ inosine-5'-monophosphate dehydrogenase	—	OG7 LdBPK_110640.1 ↔ LdBPK_191590.1	OG7
C4B63_50g5 ⚠ protein farnesyltransferase	—	OG7 LdBPK_110640.1 ↔ LdBPK_261450.1	OG7
C4B63_7g388 ⚠ geranylgeranyl transferase type II beta subun	—	OG7 LdBPK_110640.1 ↔ LdBPK_261450.1	OG7
C4B63_4g258 ⚠ prolyl-tRNA synthetase	—	OG7 LdBPK_110640.1 ↔ LdBPK_181220.1 OG7 LdBPK_110640.1 ↔ LdBPK_181230.1	OG7
C4B63_114g1 ⚠ N-acetyltransferase	—	OG7 LdBPK_110630.1 ↔ LdBPK_130260.1 OG7 LdBPK_110640.1 ↔ LdBPK_130260.1 OG7 LdBPK_130260.1 ↔ LdBPK_332700.1	OG7
C4B63_76g133 ⚠ conserved hypothetical protein	—	OG7 LdBPK_110630.1 ↔ LdBPK_220710.1	OG7
C4B63_25g203 ⚠ conserved hypothetical protein	—	OG7 LdBPK_110630.1 ↔ LdBPK_171130.1	OG7
C4B63_20g49 ⚠ conserved hypothetical protein	—	OG7 LdBPK_110630.1 ↔ LdBPK_341230.1 OG7 LdBPK_110640.1 ↔ LdBPK_341230.1 OG7 LdBPK_332700.1 ↔ LdBPK_341230.1	OG7
C4B63_243g9 ⚠ CYC2-like cyclin	—	OG7 LdBPK_110630.1 ↔ LdBPK_241960.1 OG7 LdBPK_110640.1 ↔ LdBPK_241960.1 OG7 LdBPK_241960.1 ↔ LdBPK_332700.1	OG7
C4B63_157g28 ⚠ FK506-binding protein (FKBP)-type peptidyl-pr	—	OG7 LdBPK_110630.1 ↔ LdBPK_291330.1 OG7 LdBPK_110640.1 ↔ LdBPK_291330.1 OG7 LdBPK_291330.1 ↔ LdBPK_332700.1	OG7
C4B63_2g817 ⚠ conserved hypothetical protein	—	OG7 LdBPK_110640.1 ↔ LdBPK_352820.1	OG7
C4B63_4g234 ⚠ 5-oxoprolinase	—	OG7 LdBPK_110640.1 ↔ LdBPK_181050.1	OG7
C4B63_92g124 ⚠ conserved hypothetical protein	—	OG7 LdBPK_110640.1 ↔ LdBPK_310320.1	OG7

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