C4B63_15g18

NADH-dependent fumarate reductase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_104311 OG7: OG7_0003099 203 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 203 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_193g9 ⚠
metallo-peptidase, Clan MF, Family M17
— +2 more Both
C4B63_70g129 ⚠
metallo-peptidase, Clan MF, Family M17
— +2 more Both
C4B63_12g153 ⚠
metallo-peptidase, Clan MF, Family M17
— +2 more Both
C4B63_2g450 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_42g49 ⚠
Protein aardvark
— +2 more Both
C4B63_6g257 ⚠
Vacuolar proton pump subunit B
— +2 more Both
C4B63_6g258 ⚠
Vacuolar proton pump subunit B
— +2 more Both
C4B63_16g30 ⚠
poly(A)-specific ribonuclease PARN
— Both
C4B63_41g122 ⚠
conserved hypothetical protein
— OG7
C4B63_41g125 ⚠
conserved hypothetical protein
— OG7
C4B63_43g202 ⚠
hook complex protein, conserved
— OG7
C4B63_41g119 ⚠
conserved hypothetical protein
— OG7
C4B63_17g179 ⚠
Importin subunit beta-3
— OG7
C4B63_13g113 ⚠
zinc-finger of a C2HC-type
— OG7
C4B63_56g88 ⚠
Zinc finger C2HC domain-containing protein 1C
— OG7
C4B63_19g264 ⚠
conserved hypothetical protein
— OG7
C4B63_32g238 ⚠
tubulin folding cofactor D
— +2 more Both
C4B63_32g239 ⚠
tubulin folding cofactor D
— +2 more Both
C4B63_42g187 ⚠
conserved hypothetical protein
— Both
C4B63_95g23 ⚠
N(2), N(2)-dimethylguanosine tRNA methyltrans
— Both
C4B63_14g155 ⚠
Leucine-rich repeat-containing protein 74A
— +2 more Both
C4B63_54g57 ⚠
vacuolar ATP synthase subunit d
— Both
C4B63_70g77 ⚠
acidocalcisomal pyrophosphatase
— Both
C4B63_23g248 ⚠
inorganic pyrophosphatase
— Both
C4B63_168g16 ⚠
aspartyl-tRNA synthetase
— +2 more Both
C4B63_42g203 ⚠
aspartyl-tRNA synthetase
— +2 more Both
C4B63_42g202 ⚠
aspartyl-tRNA synthetase
— +2 more Both
C4B63_102g61 ⚠
aspartyl-tRNA synthetase
— +2 more Both
C4B63_21g30 ⚠
Exportin-7-A
— Both
C4B63_24g190 ⚠
Exportin-7
— Both
C4B63_76g133 ⚠
conserved hypothetical protein
— Both
C4B63_41g203 ⚠
alanine aminotransferase
— Both
C4B63_76g41 ⚠
Probable S-adenosyl-L-methionine-binding prot
— Both
C4B63_10g487 ⚠
paraflagellar rod protein,I2 antigen
— Both
C4B63_44g120 ⚠
conserved hypothetical protein
— Both
C4B63_83g73 ⚠
ribonucleoprotein p18, mitochondrial precurso
— Both
C4B63_4g181 ⚠
Sestrin-3
— Both
C4B63_4g146 ⚠
pyruvate kinase 2
— Both
C4B63_227g20 ⚠
pyruvate kinase 2
— Both
C4B63_85g64 ⚠
DNA-damage inducible protein DDI1-like protei
— +2 more Both
C4B63_32g256 ⚠
PFU (PLAA family ubiquitin binding)
— Both
C4B63_32g255 ⚠
WD domain, G-beta repeat
— Both
C4B63_76g52 ⚠
pyrroline-5-carboxylate reductase
— Both
C4B63_10g524 ⚠
nuclear transcription factor
— Both
C4B63_63g95 ⚠
poly(A)-specific ribonuclease PARN
— Both
C4B63_41g128 ⚠
conserved hypothetical protein
— OG7
C4B63_160g6 ⚠
poly(A)-specific ribonuclease PARN
— Both
C4B63_30g161 ⚠
glutamine synthetase
— Both
C4B63_43g855c ⚠
60S ribosomal protein L37a
— Both
C4B63_242g4 ⚠
conserved hypothetical protein
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.