C4B63_14g155

Leucine-rich repeat-containing protein 74A

Trypanosoma cruzi Dm28c 2018 OG6: OG6_110710 OG7: OG7_0006349 176 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 176 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_45g121 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-biphosp	—	OG6 TCSYLVIO_004468 ↔ TCSYLVIO_004736 OG6 LdBPK_030790.1 ↔ LdBPK_364440.1 OG7 TCSYLVIO_002376 ↔ TCSYLVIO_004736 OG7 TCSYLVIO_004468 ↔ TCSYLVIO_004736	Both
C4B63_23g264 ⚠ 6-phosphofructo-2-kinase 1	—	OG6 TCSYLVIO_004468 ↔ TCSYLVIO_004736 OG6 LdBPK_030790.1 ↔ LdBPK_364440.1 OG7 TCSYLVIO_002376 ↔ TCSYLVIO_004736 OG7 TCSYLVIO_004468 ↔ TCSYLVIO_004736	Both
C4B63_2g799 ⚠ tRNA wybutosine-synthesizing protein 4	—	OG6 LdBPK_352990.1 ↔ LdBPK_364440.1 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005852 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005852	Both
C4B63_2g566 phenylalanyl-tRNA synthetase	—	OG6 LdBPK_191010.1 ↔ LdBPK_364440.1 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005548 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005548	Both
C4B63_42g187 conserved hypothetical protein	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_004736 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_004736	Both
C4B63_38g169 ⚠ calpain-like cysteine peptidase	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_007342	OG6
C4B63_22g11 ⚠ developmentally regulated phosphoprotein	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004736	Both
C4B63_54g70 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005116 +2 more	Both
C4B63_31g99 WD repeat-containing protein 17	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_010560	Both
C4B63_21g259 Small RNA degrading nuclease 5	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_010944	Both
C4B63_43g126 ATP synthase F1 subunit gamma protein	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_009375 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_009375	Both
C4B63_153g40 ⚠ inositol 5-phosphatase 1	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_007569	Both
C4B63_10g490 Hsc70-interacting protein (Hip)	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_010703 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_010703	Both
C4B63_3g553 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005116 +2 more	Both
C4B63_4g116 FACT complex subunit ssrp1-B	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006113 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006113	Both
C4B63_11g484 Leucine Rich Repeat protein	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006421 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006421	Both
C4B63_4g342 ATP synthase mitochondrial F1 complex assembl	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006163 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006163	Both
C4B63_43g186 ATP synthase	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_009332 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_009332	Both
C4B63_4g320 conserved hypothetical protein	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006181 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006181	Both
C4B63_22g164 ⚠ calpain-like cysteine peptidase	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_007342	OG6
C4B63_2g376 ⚠ ribosome assembly protein RRB1	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005619 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005619	Both
C4B63_9g450 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006138	OG6
C4B63_80g25 ⚠ ubiquitin hydrolase	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005374 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005374	Both
C4B63_31g76 ⚠ ubiquitin-activating enzyme	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_010542 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_010542	Both
C4B63_39g359 conserved hypothetical protein	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_009198 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_009198	Both
C4B63_72g79 ⚠ inositol 5-phosphatase 1	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_007569	Both
C4B63_2g513 conserved hypothetical protein	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005512 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005512	Both
C4B63_11g475 COP9 signalosome complex subunit 2	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006413 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006413	Both
C4B63_15g18 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005116 +2 more	Both
C4B63_54g57 vacuolar ATP synthase subunit d	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005104 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005104	Both
C4B63_4g377 ⚠ Zinc finger protein 474	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006138 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006138	Both
C4B63_3g552 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005116 +2 more	Both
C4B63_39g357 ATP synthase	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_009199 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_009199	Both
C4B63_4g378 ⚠ Zinc finger C2HC domain-containing protein 1C	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006138 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006138	Both
C4B63_4g422 C-terminal motor kinesin	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006065	OG6
C4B63_3g554 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005116 +2 more	Both
C4B63_3g551 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_004736 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005116 +2 more	Both
C4B63_101g15 serine peptidase, Clan SC, Family S9B	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_007536 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_007536	Both
C4B63_22g161 ⚠ calpain-like cysteine peptidase	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_007342	OG6
C4B63_43g143 ⚠ protein kinase	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_009362 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_009362	Both
C4B63_4g269 conserved hypothetical protein	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006238 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006238	Both
C4B63_3g1104 threonyl-tRNA synthetase	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_007511 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_007511	Both
C4B63_153g41 ⚠ inositol 5-phosphatase 1(fragment)	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_007569	Both
C4B63_27g4 ⚠ ubiquitin ligase	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006542 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006542	Both
C4B63_2g748 conserved hypothetical protein	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_005810 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005810	Both
C4B63_227g4 ⚠ Zinc finger protein 474	—	OG6 TCSYLVIO_004736 ↔ TCSYLVIO_006138 OG7 TCSYLVIO_004736 ↔ TCSYLVIO_006138	Both
C4B63_28g111 ⚠ synaptojanin	—	OG7 TCSYLVIO_004736 ↔ TCSYLVIO_007569	OG7
C4B63_2g502 ⚠ ubiquitin carboxyl-terminal hydrolase	—	OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005374	OG7
C4B63_252g9 ⚠ ubiquitin carboxyl-terminal hydrolase	—	OG7 TCSYLVIO_004736 ↔ TCSYLVIO_005374	OG7
C4B63_20g38 ⚠ Synaptojanin	—	OG7 TCSYLVIO_004736 ↔ TCSYLVIO_007569	OG7

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