C4B63_101g15

serine peptidase, Clan SC, Family S9B
Trypanosoma cruzi Dm28c 2018 OG6: OG6_102236 OG7: OG7_0002160 238 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 238 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_14g96 ⚠
isoleucil-tRNA synthetase
— Both
C4B63_43g202 ⚠
hook complex protein, conserved
— OG7
C4B63_41g119 ⚠
conserved hypothetical protein
— OG7
C4B63_348g23 ⚠
cytochrome b5
— OG7
C4B63_25g1526c ⚠
Acyl-lipid (8-3)-desaturase
— OG7
C4B63_10g403 ⚠
cytochrome b5
— OG7
C4B63_8g211 ⚠
cytochrome b
— OG7
C4B63_1g121c ⚠
cytochrome b5-like protein
— OG7
C4B63_70g572c ⚠
cytochrome b5
— OG7
C4B63_7g306 ⚠
cleavage and polyadenylation specificity fact
— OG7
C4B63_34g372 ⚠
cytochrome b-domain protein
— OG7
C4B63_128g66 ⚠
oligopeptidase b(fragment)
— OG7
C4B63_63g36 ⚠
prolyl endopeptidase
— OG7
C4B63_128g64 ⚠
oligopeptidase b(fragment)
— OG7
C4B63_63g37 ⚠
oligopeptidase b(fragment)
— OG7
C4B63_128g65 ⚠
prolyl oligopeptidase
— OG7
C4B63_2g450 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_72g106 ⚠
DIS3-like exonuclease(fragment)
— OG7
C4B63_276g11 ⚠
DIS3-like exonuclease(fragment)
— OG7
C4B63_30g129 ⚠
rrp44p homologue
— OG7
C4B63_32g238 ⚠
tubulin folding cofactor D
— Both
C4B63_32g239 ⚠
tubulin folding cofactor D
— Both
C4B63_42g187
conserved hypothetical protein
— Both
C4B63_27g4 ⚠
ubiquitin ligase
— Both
C4B63_122g21 ⚠
ubiquitin ligase
— Both
C4B63_14g155
Leucine-rich repeat-containing protein 74A
— Both
C4B63_54g57
vacuolar ATP synthase subunit d
— Both
C4B63_70g77 ⚠
acidocalcisomal pyrophosphatase
— Both
C4B63_23g248 ⚠
inorganic pyrophosphatase
— Both
C4B63_11g484
Leucine Rich Repeat protein
— Both
C4B63_49g165 ⚠
alanyl-tRNA synthetase
— Both
C4B63_63g30
Histone-lysine N-methyltransferase ATXR2
— OG6
C4B63_23g207 ⚠
tRNA (cytosine(34)-C(5))-methyltransferase
— Both
C4B63_81g44 ⚠
tRNA (cytosine(34)-C(5))-methyltransferase
— Both
C4B63_54g28
conserved hypothetical protein
— Both
C4B63_85g64
DNA-damage inducible protein DDI1-like protei
— Both
C4B63_184g38 ⚠
TPR-repeat protein
— OG6
C4B63_13g167 ⚠
stress-inducible protein STI1-like
— OG6
C4B63_175g8 ⚠
TPR-repeat protein
— OG6
C4B63_23g110 ⚠
UDP-glucose:glycoprotein glucosyltransferase
— Both
C4B63_32g256 ⚠
PFU (PLAA family ubiquitin binding)
— Both
C4B63_23g109 ⚠
UDP-glucose:glycoprotein glucosyltransferase
— Both
C4B63_32g255 ⚠
WD domain, G-beta repeat
— Both
C4B63_19g137 ⚠
cleavage and polyadenylation specificity fact
— Both
C4B63_49g164 ⚠
alanyl-tRNA synthetase
— Both
C4B63_56g85 ⚠
conserved hypothetical protein
— Both
C4B63_109g37 ⚠
Gar1/Naf1 RNA binding region containing prote
— Both
C4B63_34g118 ⚠
conserved hypothetical protein
— Both
C4B63_56g84 ⚠
conserved hypothetical protein
— Both
C4B63_21g30 ⚠
Exportin-7-A
— Both
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Orthogroup expansion — connections between the query proteins
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How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.