C4B63_32g238

tubulin folding cofactor D

Trypanosoma cruzi Dm28c 2018 OG6: OG6_102599 OG7: OG7_0006853 230 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 230 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_16g30 ⚠ poly(A)-specific ribonuclease PARN	—	OG6 LdBPK_230660.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 LdBPK_230660.1 ↔ LdBPK_242100.1	Both
C4B63_63g95 ⚠ poly(A)-specific ribonuclease PARN	—	OG6 LdBPK_230660.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 LdBPK_230660.1 ↔ LdBPK_242100.1	Both
C4B63_160g6 ⚠ poly(A)-specific ribonuclease PARN	—	OG6 LdBPK_230660.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 LdBPK_230660.1 ↔ LdBPK_242100.1	Both
C4B63_42g187 ⚠ conserved hypothetical protein	—	OG6 LdBPK_242100.1 ↔ LdBPK_300580.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003118 OG7 LdBPK_242100.1 ↔ LdBPK_300580.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003118	Both
C4B63_42g202 ⚠ aspartyl-tRNA synthetase	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003107 OG7 LdBPK_242100.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003107	Both
C4B63_22g11 ⚠ developmentally regulated phosphoprotein	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_007262	Both
C4B63_2g74 ⚠ poly(A)-specific ribonuclease PARN(fragment)	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 LdBPK_230660.1 ↔ LdBPK_242100.1	OG7
C4B63_31g99 ⚠ WD repeat-containing protein 17	—	OG6 LdBPK_080420.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_010560	Both
C4B63_2g75 ⚠ poly(A)-specific ribonuclease PARN(fragment)	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 LdBPK_230660.1 ↔ LdBPK_242100.1	OG7
C4B63_102g61 ⚠ aspartyl-tRNA synthetase	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003107 OG7 LdBPK_242100.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003107	Both
C4B63_7g79 ⚠ aspartyl-tRNA synthetase	—	OG6 LdBPK_242100.1 ↔ LdBPK_342110.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003867 OG7 LdBPK_242100.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003867 +1 more	Both
C4B63_4g258 ⚠ prolyl-tRNA synthetase	—	OG6 LdBPK_181220.1 ↔ LdBPK_242100.1 OG6 LdBPK_181230.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006246 OG7 LdBPK_181220.1 ↔ LdBPK_242100.1 +2 more	Both
C4B63_2g566 ⚠ phenylalanyl-tRNA synthetase	—	OG6 LdBPK_191010.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005548 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_242100.1	Both
C4B63_42g203 ⚠ aspartyl-tRNA synthetase	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003107 OG7 LdBPK_242100.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003107	Both
C4B63_28g25 ⚠ pyruvate dehydrogenase (lipoamide) kinase	—	OG6 LdBPK_240010.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_001571 OG7 LdBPK_240010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001571 +1 more	Both
C4B63_7g377 ⚠ [Pyruvate dehydrogenase (acetyl-transferring)	—	OG7 LdBPK_240010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_007262	OG7
C4B63_168g16 ⚠ aspartyl-tRNA synthetase	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003107 OG7 LdBPK_242100.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003107	Both
C4B63_41g119 ⚠ conserved hypothetical protein	—	OG7 LdBPK_120255.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_006977	OG7
C4B63_41g125 ⚠ conserved hypothetical protein	—	OG7 LdBPK_120255.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_006977	OG7
C4B63_41g128 ⚠ conserved hypothetical protein	—	OG7 LdBPK_120255.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_006977	OG7
C4B63_224g16 ⚠ conserved hypothetical protein	—	OG7 LdBPK_120255.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_006977	OG7
C4B63_41g122 ⚠ conserved hypothetical protein	—	OG7 LdBPK_120255.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_006977	OG7
C4B63_4g577 ⚠ eukaryotic translation initiation factor 4E (	—	OG7 LdBPK_242100.1 ↔ LdBPK_300460.1	OG7
C4B63_4g377 ⚠ Zinc finger protein 474	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006138 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_006138	Both
C4B63_171g22 ⚠ eukaryotic translation initiation factor 4E (	—	OG7 LdBPK_242100.1 ↔ LdBPK_300460.1	OG7
C4B63_17g50 ⚠ Outer row dynein-assembly protein 7	—	OG7 LdBPK_242100.1 ↔ LdBPK_261200.1	OG7
C4B63_157g19 ⚠ eukaryotic translation initiation factor 4E (	—	OG7 LdBPK_242100.1 ↔ LdBPK_300460.1	OG7
C4B63_39g340 ⚠ replication factor C, subunit 4	—	OG7 LdBPK_241010.1 ↔ LdBPK_242100.1	OG7
C4B63_63g41 ⚠ replication factor C, subunit 3	—	OG7 LdBPK_241010.1 ↔ LdBPK_242100.1	OG7
C4B63_61g81 ⚠ conserved hypothetical protein	—	OG7 LdBPK_241010.1 ↔ LdBPK_242100.1	OG7
C4B63_18g277 ⚠ replication factor C, subunit 2	—	OG7 LdBPK_241010.1 ↔ LdBPK_242100.1	OG7
C4B63_61g82 ⚠ Chromosome transmission fidelity protein 18 h	—	OG7 LdBPK_241010.1 ↔ LdBPK_242100.1	OG7
C4B63_2g762 ⚠ replication factor C, subunit 3	—	OG7 LdBPK_241010.1 ↔ LdBPK_242100.1	OG7
C4B63_22g108 ⚠ Replication Factor C Subunit 1-related protei	—	OG7 LdBPK_241010.1 ↔ LdBPK_242100.1	OG7
C4B63_42g49 ⚠ Protein aardvark	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003145 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003145	Both
C4B63_227g4 ⚠ Zinc finger protein 474	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006138 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_006138	Both
C4B63_2g748 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005810 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_005810	Both
C4B63_27g4 ⚠ ubiquitin ligase	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006542 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_006542	Both
C4B63_7g417 ⚠ snoRNP protein GAR1	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003690 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003690	Both
C4B63_21g30 ⚠ Exportin-7-A	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003586 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003586	Both
C4B63_83g73 ⚠ ribonucleoprotein p18, mitochondrial precurso	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_002426 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_002426	Both
C4B63_3g554 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_005116 +2 more	Both
C4B63_22g123 ⚠ Mucin-associated surface protein (MASP)	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_001559	OG6
C4B63_44g120 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_002919 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_002919	Both
C4B63_70g126 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_001673 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001673	Both
C4B63_42g221 ⚠ kinesin	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003093	OG6
C4B63_4g422 ⚠ C-terminal motor kinesin	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_006065	OG6
C4B63_70g129 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_001670 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001670	Both
C4B63_24g190 ⚠ Exportin-7	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003586 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003586	Both
C4B63_3g552 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005116 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_005116 +2 more	Both

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