C4B63_28g25

pyruvate dehydrogenase (lipoamide) kinase

Trypanosoma cruzi Dm28c 2018 OG6: OG6_146742 OG7: OG7_0002830 181 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 181 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_16g30 ⚠ poly(A)-specific ribonuclease PARN	—	OG6 LdBPK_230660.1 ↔ LdBPK_240010.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 +1 more	Both
C4B63_63g95 ⚠ poly(A)-specific ribonuclease PARN	—	OG6 LdBPK_230660.1 ↔ LdBPK_240010.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 +1 more	Both
C4B63_160g6 ⚠ poly(A)-specific ribonuclease PARN	—	OG6 LdBPK_230660.1 ↔ LdBPK_240010.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 +1 more	Both
C4B63_2g75 ⚠ poly(A)-specific ribonuclease PARN(fragment)	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
C4B63_2g74 ⚠ poly(A)-specific ribonuclease PARN(fragment)	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
C4B63_32g239 ⚠ tubulin folding cofactor D	—	OG6 LdBPK_240010.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_001571 OG7 LdBPK_240010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001571 +1 more	Both
C4B63_7g377 ⚠ [Pyruvate dehydrogenase (acetyl-transferring)	—	OG7 Tb927.1.1000 ↔ Tb927.11.4780 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007262	OG7
C4B63_42g202 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
C4B63_7g79 ⚠ aspartyl-tRNA synthetase	—	OG6 TCSYLVIO_001571 ↔ TCSYLVIO_003867 OG6 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 +1 more	Both
C4B63_42g203 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
C4B63_168g16 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
C4B63_102g61 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
C4B63_2g566 ⚠ phenylalanyl-tRNA synthetase	—	OG6 TCSYLVIO_001571 ↔ TCSYLVIO_005548 OG6 LdBPK_191010.1 ↔ LdBPK_240010.1 OG7 TCSYLVIO_005548 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005548 +1 more	Both
C4B63_41g128 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 LdBPK_120255.1 ↔ LdBPK_240010.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977	OG7
C4B63_22g11 ⚠ developmentally regulated phosphoprotein	—	OG6 TCSYLVIO_001571 ↔ TCSYLVIO_007262 OG6 Tb927.1.1000 ↔ Tb927.11.4780 OG7 Tb927.1.1000 ↔ Tb927.11.4780 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007262	Both
C4B63_32g238 ⚠ tubulin folding cofactor D	—	OG6 LdBPK_240010.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_001571 OG7 LdBPK_240010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001571 +1 more	Both
C4B63_224g16 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 LdBPK_120255.1 ↔ LdBPK_240010.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977	OG7
C4B63_41g122 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 LdBPK_120255.1 ↔ LdBPK_240010.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977	OG7
C4B63_23g186 ⚠ aspartyl aminopeptidase	—	OG6 TCSYLVIO_001571 ↔ TCSYLVIO_004406 OG6 LdBPK_240010.1 ↔ LdBPK_292470.1 OG7 LdBPK_240010.1 ↔ LdBPK_292470.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004406	Both
C4B63_41g125 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 LdBPK_120255.1 ↔ LdBPK_240010.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977	OG7
C4B63_41g119 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 LdBPK_120255.1 ↔ LdBPK_240010.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977	OG7
C4B63_78g10 ⚠ conserved hypothetical protein	—	OG7 LdBPK_071090.1 ↔ LdBPK_240010.1	OG7
C4B63_1g48 ⚠ Deubiquitinase DESI2	—	OG6 LdBPK_240010.1 ↔ LdBPK_240660.1 OG7 LdBPK_240010.1 ↔ LdBPK_240660.1	Both
C4B63_13g160 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-bisphos	—	OG7 TCSYLVIO_002376 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_002376	OG7
C4B63_23g264 ⚠ 6-phosphofructo-2-kinase 1	—	OG7 TCSYLVIO_002376 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_002376	OG7
C4B63_45g121 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-biphosp	—	OG7 TCSYLVIO_002376 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_002376	OG7
C4B63_271g10 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_005619 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005619	OG7
C4B63_43g202 ⚠ hook complex protein, conserved	—	OG7 TCSYLVIO_005619 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005619	OG7
C4B63_56g104 ⚠ Phosphatidylinositol 4-phosphate 5-kinase	—	OG7 LdBPK_030950.1 ↔ LdBPK_200310.1	OG7
C4B63_23g242 ⚠ radial spoke protein RSP10	—	OG7 LdBPK_030950.1 ↔ LdBPK_200310.1	OG7
C4B63_2g368 ⚠ conserved hypothetical protein	—	OG6 LdBPK_240010.1 ↔ LdBPK_331980.1 OG7 LdBPK_240010.1 ↔ LdBPK_331980.1	Both
C4B63_300g18 ⚠ Glycerophosphoryl diester phosphodiesterase f	—	OG7 TCSYLVIO_000902 ↔ TCSYLVIO_007262	OG7
C4B63_28g76 ⚠ Leucine-rich repeat-containing protein 9	—	OG6 LdBPK_240010.1 ↔ LdBPK_240500.1 OG7 LdBPK_240010.1 ↔ LdBPK_240500.1	Both
C4B63_22g22 ⚠ ARM-like helical domain-containing protein	—	OG6 LdBPK_240010.1 ↔ LdBPK_312230.1	OG6
C4B63_57g110 ⚠ conserved hypothetical protein	—	OG6 LdBPK_240010.1 ↔ LdBPK_363000.1 OG7 LdBPK_240010.1 ↔ LdBPK_363000.1	Both
C4B63_28g93 ⚠ DeSI-like protein At4g17486	—	OG6 LdBPK_240010.1 ↔ LdBPK_240660.1 OG7 LdBPK_240010.1 ↔ LdBPK_240660.1	Both
C4B63_2g731 zinc-finger protein	—	OG6 LdBPK_240010.1 ↔ LdBPK_353550.1	OG6
C4B63_22g23 ⚠ ARM-like helical domain-containing protein	—	OG6 LdBPK_240010.1 ↔ LdBPK_312230.1	OG6
C4B63_6g400 ⚠ conserved hypothetical protein	—	OG6 LdBPK_240010.1 ↔ LdBPK_282030.1 OG7 LdBPK_240010.1 ↔ LdBPK_282030.1	Both
C4B63_10g293 Phosphatidylinositol 4-phosphate 5-kinase 6	—	OG6 LdBPK_240010.1 ↔ LdBPK_291830.1	OG6
C4B63_235g21 ⚠ DeSI-like protein At4g17486	—	OG6 LdBPK_240010.1 ↔ LdBPK_240660.1 OG7 LdBPK_240010.1 ↔ LdBPK_240660.1	Both
C4B63_32g256 ⚠ PFU (PLAA family ubiquitin binding)	—	OG6 TCSYLVIO_001314 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_001314 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_001314 ↔ TCSYLVIO_007262	Both
C4B63_33g8 ⚠ Phosphatidylinositol 4-phosphate 5-kinase	—	OG7 LdBPK_030950.1 ↔ LdBPK_200310.1	OG7
C4B63_2g450 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_001670	OG7
C4B63_4g234 ⚠ 5-oxoprolinase	—	OG6 LdBPK_181050.1 ↔ LdBPK_240010.1 OG7 LdBPK_181050.1 ↔ LdBPK_240010.1	Both
C4B63_4g235 ⚠ 5-oxoprolinase	—	OG6 LdBPK_181050.1 ↔ LdBPK_240010.1 OG7 LdBPK_181050.1 ↔ LdBPK_240010.1	Both
C4B63_32g255 ⚠ WD domain, G-beta repeat	—	OG6 TCSYLVIO_001314 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_001314 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_001314 ↔ TCSYLVIO_007262	Both
C4B63_282g21 ⚠ conserved hypothetical protein	—	OG6 LdBPK_240010.1 ↔ LdBPK_282030.1 OG7 LdBPK_240010.1 ↔ LdBPK_282030.1	Both
C4B63_1g43 ⚠ DeSI-like protein At4g17486	—	OG6 LdBPK_240010.1 ↔ LdBPK_240660.1 OG7 LdBPK_240010.1 ↔ LdBPK_240660.1	Both
C4B63_101g26 ⚠ conserved hypothetical protein	—	OG6 LdBPK_240010.1 ↔ LdBPK_362610.1 OG7 LdBPK_240010.1 ↔ LdBPK_362610.1	Both

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