C4B63_23g186

aspartyl aminopeptidase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_102047 OG7: OG7_0006128 270 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 270 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_22g11 ⚠
developmentally regulated phosphoprotein
— OG7
C4B63_7g377 ⚠
[Pyruvate dehydrogenase (acetyl-transferring)
— OG7
C4B63_28g25 ⚠
pyruvate dehydrogenase (lipoamide) kinase
— Both
C4B63_22g113 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_78g9 ⚠
conserved hypothetical protein
— OG7
C4B63_78g13 ⚠
Proteasome activator complex subunit 4
— OG7
C4B63_78g10 ⚠
conserved hypothetical protein
— OG7
C4B63_63g81 ⚠
protein transport protein Sec23A
— OG7
C4B63_10g291 ⚠
Paraflagellar rod protein 2
— OG7
C4B63_9g266 ⚠
paraflagellar rod protein 5
— OG7
C4B63_10g289 ⚠
Paraflagellar rod protein 2
— OG7
C4B63_9g267 ⚠
paraflagellar rod protein 5
— OG7
C4B63_10g290 ⚠
Paraflagellar rod protein 2
— OG7
C4B63_10g288 ⚠
Paraflagellar rod protein 2
— OG7
C4B63_10g287 ⚠
Paraflagellar rod protein 2
— OG7
C4B63_46g54 ⚠
Dpy-30 motif containing protein
— OG7
C4B63_25g219 ⚠
conserved hypothetical protein
— OG7
C4B63_25g218 ⚠
Centrosomal protein of 164 kDa
— OG7
C4B63_6g252 ⚠
Centrosomal protein of 164 kDa
— OG7
C4B63_17g127 ⚠
Desumoylating isopeptidase 1
— OG7
C4B63_186g6 ⚠
Desumoylating isopeptidase 1
— OG7
C4B63_51g200 ⚠
mitochondrial DNA polymerase I protein B
— OG7
C4B63_39g340 ⚠
replication factor C, subunit 4
— OG7
C4B63_63g41 ⚠
replication factor C, subunit 3
— OG7
C4B63_61g81 ⚠
conserved hypothetical protein
— OG7
C4B63_18g277 ⚠
replication factor C, subunit 2
— OG7
C4B63_61g82 ⚠
Chromosome transmission fidelity protein 18 h
— OG7
C4B63_124g1 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_17g277 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_17g278 ⚠
phosphatidylinositol 3-related kinase
— OG7
C4B63_7g380 ⚠
phosphatidylinositol 3-kinase(fragment)
— OG7
C4B63_124g3 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_34g361 ⚠
phosphatidylinositol kinase related protein
— OG7
C4B63_2g762 ⚠
replication factor C, subunit 3
— OG7
C4B63_22g108 ⚠
Replication Factor C Subunit 1-related protei
— OG7
C4B63_124g2 ⚠
phosphatidylinositol 3-kinase
— OG7
C4B63_31g99
WD repeat-containing protein 17
— Both
C4B63_162g37 ⚠
mitochondrial DNA polymerase I protein D
— Both
C4B63_10g293
Phosphatidylinositol 4-phosphate 5-kinase 6
— OG6
C4B63_12g208
leucine-rich repeat protein (LRRP)
— Both
C4B63_142g11 ⚠
Protein shuttle craft
— Both
C4B63_30g226 ⚠
lipin
— Both
C4B63_30g227 ⚠
lipin
— Both
C4B63_248g25 ⚠
Centrosomal protein of 164 kDa
— Both
C4B63_9g249 ⚠
conserved hypothetical protein
— Both
C4B63_12g211 ⚠
conserved hypothetical protein
— Both
C4B63_33g8 ⚠
Phosphatidylinositol 4-phosphate 5-kinase
— Both
C4B63_29g3 ⚠
Phosphatidylinositol 4-phosphate 5-kinase
— Both
C4B63_56g104 ⚠
Phosphatidylinositol 4-phosphate 5-kinase
— Both
C4B63_9g250 ⚠
Dpy-30 motif containing protein
— Both
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.