C4B63_7g377

[Pyruvate dehydrogenase (acetyl-transferring)] kinase 1, mitochondrial

Trypanosoma cruzi Dm28c 2018 OG6: OG6_146732 OG7: OG7_0002830 165 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 165 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_2g566 ⚠ phenylalanyl-tRNA synthetase	—	OG7 TCSYLVIO_005548 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_240010.1	OG7
C4B63_32g238 ⚠ tubulin folding cofactor D	—	OG7 LdBPK_240010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_007262	OG7
C4B63_23g186 ⚠ aspartyl aminopeptidase	—	OG7 LdBPK_240010.1 ↔ LdBPK_292470.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004406	OG7
C4B63_32g239 ⚠ tubulin folding cofactor D	—	OG7 LdBPK_240010.1 ↔ LdBPK_242100.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_007262	OG7
C4B63_41g119 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 LdBPK_120255.1 ↔ LdBPK_240010.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977	OG7
C4B63_42g202 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
C4B63_41g125 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 LdBPK_120255.1 ↔ LdBPK_240010.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977	OG7
C4B63_41g122 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 LdBPK_120255.1 ↔ LdBPK_240010.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977	OG7
C4B63_224g16 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 LdBPK_120255.1 ↔ LdBPK_240010.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977	OG7
C4B63_41g128 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_006977 ↔ TCSYLVIO_007262 OG7 LdBPK_120255.1 ↔ LdBPK_240010.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006977	OG7
C4B63_42g203 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
C4B63_63g95 ⚠ poly(A)-specific ribonuclease PARN	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
C4B63_16g30 ⚠ poly(A)-specific ribonuclease PARN	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
C4B63_2g75 ⚠ poly(A)-specific ribonuclease PARN(fragment)	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
C4B63_2g74 ⚠ poly(A)-specific ribonuclease PARN(fragment)	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
C4B63_28g25 ⚠ pyruvate dehydrogenase (lipoamide) kinase	—	OG7 Tb927.1.1000 ↔ Tb927.11.4780 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007262	OG7
C4B63_22g11 ⚠ developmentally regulated phosphoprotein	—	OG7 Tb927.1.1000 ↔ Tb927.11.4780 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007262	OG7
C4B63_160g6 ⚠ poly(A)-specific ribonuclease PARN	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
C4B63_7g79 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
C4B63_102g61 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
C4B63_168g16 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007262 OG7 LdBPK_240010.1 ↔ LdBPK_342110.1 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003867	OG7
C4B63_157g28 ⚠ FK506-binding protein (FKBP)-type peptidyl-pr	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005957	OG7
C4B63_171g30 ⚠ FK506-binding protein (FKBP)-type peptidyl-pr	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005957	OG7
C4B63_14g103 ⚠ beta adaptin	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_004597 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_007262	OG7
C4B63_128g59 ⚠ dihydrolipoamide branched chain transacylase	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009880 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009880	OG7
C4B63_10g522 ⚠ FACT complex subunit SPT16	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010728 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010728	OG7
C4B63_83g73 ⚠ ribonucleoprotein p18, mitochondrial precurso	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_002426 OG7 TCSYLVIO_002426 ↔ TCSYLVIO_007262	OG7
C4B63_73g1 ⚠ arginine N-methyltransferase	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006901	OG7
C4B63_26g245 ⚠ inositol/phosphatidylinositol phosphatase	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007569	OG7
C4B63_45g229 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006116	OG7
C4B63_13g257 ⚠ endonuclease/exonuclease/phosphatase	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007569	OG7
C4B63_30g184 ⚠ Basic immunoglobulin-like variable motif-cont	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_001826	OG7
C4B63_39g359 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_009198 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_009198	OG7
C4B63_72g79 ⚠ inositol 5-phosphatase 1	—	OG7 TCSYLVIO_007262 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_007569	OG7
C4B63_3g553 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
C4B63_30g226 ⚠ lipin	—	OG7 TCSYLVIO_001856 ↔ TCSYLVIO_007262	OG7
C4B63_4g140 ⚠ conserved hypothetical protein	—	OG7 LdBPK_161200.1 ↔ LdBPK_240010.1	OG7
C4B63_24g190 ⚠ Exportin-7	—	OG7 TCSYLVIO_003586 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003586	OG7
C4B63_21g30 ⚠ Exportin-7-A	—	OG7 TCSYLVIO_003586 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003586	OG7
C4B63_85g64 ⚠ DNA-damage inducible protein DDI1-like protei	—	OG7 TCSYLVIO_003428 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003428	OG7
C4B63_3g550 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
C4B63_54g71 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
C4B63_15g19 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
C4B63_54g70 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
C4B63_3g551 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7
C4B63_49g325c ⚠ peptidyl-prolyl cis-trans isomerase	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005957	OG7
C4B63_12g234 ⚠ protein transport protein Sec31	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_001623	OG7
C4B63_12g235 ⚠ protein transport protein Sec31	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_001623	OG7
C4B63_30g232 ⚠ protein arginine n-methyltransferase 7	—	OG7 TCSYLVIO_001571 ↔ TCSYLVIO_006901	OG7
C4B63_3g552 ⚠ NADH-dependent fumarate reductase	—	OG7 TCSYLVIO_005159 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_008502	OG7

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