C4B63_16g30

poly(A)-specific ribonuclease PARN

Trypanosoma cruzi Dm28c 2018 OG6: OG6_102215 OG7: OG7_0005534 223 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 223 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_32g239 ⚠ tubulin folding cofactor D	—	OG6 LdBPK_230660.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 LdBPK_230660.1 ↔ LdBPK_242100.1	Both
C4B63_28g25 ⚠ pyruvate dehydrogenase (lipoamide) kinase	—	OG6 LdBPK_230660.1 ↔ LdBPK_240010.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 +1 more	Both
C4B63_4g235 ⚠ 5-oxoprolinase	—	OG6 TCSYLVIO_004635 ↔ TCSYLVIO_006232 OG6 LdBPK_181050.1 ↔ LdBPK_230660.1 OG7 TCSYLVIO_004635 ↔ TCSYLVIO_006232 OG7 LdBPK_181050.1 ↔ LdBPK_230660.1	Both
C4B63_4g234 ⚠ 5-oxoprolinase	—	OG6 TCSYLVIO_004635 ↔ TCSYLVIO_006232 OG6 LdBPK_181050.1 ↔ LdBPK_230660.1 OG7 TCSYLVIO_004635 ↔ TCSYLVIO_006232 OG7 LdBPK_181050.1 ↔ LdBPK_230660.1	Both
C4B63_7g79 ⚠ aspartyl-tRNA synthetase	—	OG6 LdBPK_230660.1 ↔ LdBPK_342110.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_003867 OG7 LdBPK_230660.1 ↔ LdBPK_342110.1	Both
C4B63_2g566 ⚠ phenylalanyl-tRNA synthetase	—	OG6 LdBPK_191010.1 ↔ LdBPK_230660.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_005548 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_230660.1	Both
C4B63_32g238 ⚠ tubulin folding cofactor D	—	OG6 LdBPK_230660.1 ↔ LdBPK_242100.1 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001302 OG7 LdBPK_230660.1 ↔ LdBPK_242100.1	Both
C4B63_102g61 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_003867 OG7 LdBPK_230660.1 ↔ LdBPK_342110.1	OG7
C4B63_7g377 ⚠ [Pyruvate dehydrogenase (acetyl-transferring)	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	OG7
C4B63_22g11 ⚠ developmentally regulated phosphoprotein	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001571 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007262 OG7 LdBPK_230660.1 ↔ LdBPK_240010.1	Both
C4B63_41g128 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_230660.1	OG7
C4B63_168g16 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_003867 OG7 LdBPK_230660.1 ↔ LdBPK_342110.1	OG7
C4B63_224g16 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_230660.1	OG7
C4B63_42g203 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_003867 OG7 LdBPK_230660.1 ↔ LdBPK_342110.1	OG7
C4B63_42g202 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_003867 OG7 LdBPK_230660.1 ↔ LdBPK_342110.1	OG7
C4B63_41g119 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_230660.1	OG7
C4B63_41g122 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_230660.1	OG7
C4B63_41g125 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_000055 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_230660.1	OG7
C4B63_2g785 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004635 ↔ TCSYLVIO_005838 OG7 TCSYLVIO_004635 ↔ TCSYLVIO_005838	Both
C4B63_144g102c ⚠ U6 snRNA-associated Sm-like protein LSm6p	—	OG7 Tb927.5.4030 ↔ Tb927.8.2850	OG7
C4B63_6g521 ⚠ DIS3-like exonuclease	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_004635	OG7
C4B63_72g106 ⚠ DIS3-like exonuclease(fragment)	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_004635	OG7
C4B63_276g11 ⚠ DIS3-like exonuclease(fragment)	—	OG7 TCSYLVIO_001759 ↔ TCSYLVIO_004635	OG7
C4B63_69g174c ⚠ U6 snRNA-associated Sm-like protein LSm6p	—	OG7 Tb927.5.4030 ↔ Tb927.8.2850	OG7
C4B63_42g593c ⚠ small nuclear ribonucleoprotein Sm-E	—	OG7 Tb927.5.4030 ↔ Tb927.8.2850	OG7
C4B63_17g180c ⚠ U6 snRNA-associated Sm-like protein LSm4	—	OG6 Tb927.11.13960 ↔ Tb927.8.2850 OG7 Tb927.11.13960 ↔ Tb927.8.2850	Both
C4B63_10g125 ⚠ ankyrin	—	OG6 TCSYLVIO_004284 ↔ TCSYLVIO_004635 OG7 TCSYLVIO_004284 ↔ TCSYLVIO_004635	Both
C4B63_42g49 ⚠ Protein aardvark	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_003145 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_003145	Both
C4B63_2g748 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_005810 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_005810	Both
C4B63_27g4 ⚠ ubiquitin ligase	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_006542 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_006542	Both
C4B63_102g71 ⚠ Programmed cell death protein 2, C-terminal d	—	OG6 TCSYLVIO_004635 ↔ TCSYLVIO_008261 OG7 TCSYLVIO_004635 ↔ TCSYLVIO_008261	Both
C4B63_7g417 ⚠ snoRNP protein GAR1	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_003690 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_003690	Both
C4B63_21g30 ⚠ Exportin-7-A	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_003586 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_003586	Both
C4B63_153g41 ⚠ inositol 5-phosphatase 1(fragment)	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007569	Both
C4B63_7g395 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_003707 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_003707	Both
C4B63_297g14 ⚠ phenylalanyl-tRNA synthetase alpha chain	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_004213 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_004213	Both
C4B63_3g1104 ⚠ threonyl-tRNA synthetase	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_007511 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_007511	Both
C4B63_87g16 ⚠ pitrilysin-like metalloprotease	—	OG6 TCSYLVIO_004635 ↔ TCSYLVIO_009816 OG7 TCSYLVIO_004635 ↔ TCSYLVIO_009816	Both
C4B63_3g552 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_000055 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_008502	Both
C4B63_4g422 ⚠ C-terminal motor kinesin	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_006065	OG6
C4B63_3g1118 ⚠ choline/ethanolamine kinase	—	OG6 TCSYLVIO_004635 ↔ TCSYLVIO_007612 OG7 TCSYLVIO_004635 ↔ TCSYLVIO_007612	Both
C4B63_168g23 ⚠ Programmed cell death protein 2, C-terminal d	—	OG6 TCSYLVIO_004635 ↔ TCSYLVIO_008261 OG7 TCSYLVIO_004635 ↔ TCSYLVIO_008261	Both
C4B63_70g129 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_001670 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001670	Both
C4B63_83g73 ⚠ ribonucleoprotein p18, mitochondrial precurso	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_002426 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_002426	Both
C4B63_70g77 ⚠ acidocalcisomal pyrophosphatase	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_001709 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001709	Both
C4B63_38g42 ⚠ tRNA nucleotidyltransferase	—	OG6 TCSYLVIO_004635 ↔ TCSYLVIO_007204 OG7 TCSYLVIO_004635 ↔ TCSYLVIO_007204	Both
C4B63_7g157 ⚠ D-isomer specific 2-hydroxyacid dehydrogenase	—	OG6 TCSYLVIO_004635 ↔ TCSYLVIO_011102 OG7 TCSYLVIO_004635 ↔ TCSYLVIO_011102	Both
C4B63_54g57 ⚠ vacuolar ATP synthase subunit d	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_005104 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_005104	Both
C4B63_48g163 ⚠ ARF-like 2 binding protein BART	—	OG6 TCSYLVIO_004635 ↔ TCSYLVIO_004918 OG7 TCSYLVIO_004635 ↔ TCSYLVIO_004918	Both
C4B63_70g126 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_000055 ↔ TCSYLVIO_001673 OG7 TCSYLVIO_000055 ↔ TCSYLVIO_001673	Both

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