C4B63_42g49

Protein aardvark
Trypanosoma cruzi Dm28c 2018 OG6: OG6_113914 OG7: OG7_0021257 151 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Network view all shared interactors, plus up to 150 more
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Interactions 151 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_70g129 ⚠
metallo-peptidase, Clan MF, Family M17
— Both
C4B63_12g153 ⚠
metallo-peptidase, Clan MF, Family M17
— Both
C4B63_193g9 ⚠
metallo-peptidase, Clan MF, Family M17
— Both
C4B63_3g550 ⚠
NADH-dependent fumarate reductase
— +2 more Both
C4B63_54g71 ⚠
NADH-dependent fumarate reductase
— +2 more Both
C4B63_15g19 ⚠
NADH-dependent fumarate reductase
— +2 more Both
C4B63_54g70 ⚠
NADH-dependent fumarate reductase
— +2 more Both
C4B63_3g553 ⚠
NADH-dependent fumarate reductase
— +2 more Both
C4B63_15g18 ⚠
NADH-dependent fumarate reductase
— +2 more Both
C4B63_3g552 ⚠
NADH-dependent fumarate reductase
— +2 more Both
C4B63_3g554 ⚠
NADH-dependent fumarate reductase
— +2 more Both
C4B63_3g551 ⚠
NADH-dependent fumarate reductase
— +2 more Both
C4B63_2g450 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_32g255 ⚠
WD domain, G-beta repeat
— Both
C4B63_25g202 ⚠
conserved hypothetical protein
— OG7
C4B63_76g133 ⚠
conserved hypothetical protein
— Both
C4B63_242g4 ⚠
conserved hypothetical protein
— Both
C4B63_160g6 ⚠
poly(A)-specific ribonuclease PARN
— Both
C4B63_16g30 ⚠
poly(A)-specific ribonuclease PARN
— Both
C4B63_63g95 ⚠
poly(A)-specific ribonuclease PARN
— Both
C4B63_10g524 ⚠
nuclear transcription factor
— Both
C4B63_23g248 ⚠
inorganic pyrophosphatase
— Both
C4B63_70g77 ⚠
acidocalcisomal pyrophosphatase
— Both
C4B63_42g187
conserved hypothetical protein
— Both
C4B63_32g239 ⚠
tubulin folding cofactor D
— Both
C4B63_32g238 ⚠
tubulin folding cofactor D
— Both
C4B63_22g77
conserved hypothetical protein
— Both
C4B63_48g124 ⚠
neurobeachin/beige protein
— OG7
C4B63_48g123 ⚠
neurobeachin/beige protein
— OG7
C4B63_8g527 ⚠
pseudouridylate synthase I
— OG7
C4B63_4g514 ⚠
tRNA pseudouridine synthase A-like protein
— OG7
C4B63_112g14 ⚠
neurobeachin/beige-like protein
— OG7
C4B63_48g122 ⚠
neurobeachin/beige protein
— OG7
C4B63_47g49 ⚠
tRNA pseudouridine synthase 1
— OG7
C4B63_112g13 ⚠
neurobeachin/beige-like protein(fragment)
— OG7
C4B63_17g182
phosphatidylinositol 3-kinase catalytic subun
— OG7
C4B63_102g61 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_271g10 ⚠
conserved hypothetical protein
— OG7
C4B63_7g377 ⚠
[Pyruvate dehydrogenase (acetyl-transferring)
— OG7
C4B63_13g257 ⚠
endonuclease/exonuclease/phosphatase
— OG7
C4B63_2g83 ⚠
ubiquitin hydrolase
— OG7
C4B63_26g245 ⚠
inositol/phosphatidylinositol phosphatase
— OG7
C4B63_42g202 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_41g119 ⚠
conserved hypothetical protein
— OG7
C4B63_14g103 ⚠
beta adaptin
— OG7
C4B63_40g106 ⚠
Adaptor protein complex AP-3 subunit beta-3
— OG7
C4B63_41g125 ⚠
conserved hypothetical protein
— OG7
C4B63_4g63
polyprenyl synthase
— OG7
C4B63_63g81 ⚠
protein transport protein Sec23A
— OG7
C4B63_142g11 ⚠
Protein shuttle craft
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.