C4B63_42g187

conserved hypothetical protein

Trypanosoma cruzi Dm28c 2018 OG6: OG6_158251 OG7: OG7_0052285 230 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Interactions 230 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_31g76 ⚠ ubiquitin-activating enzyme	—	OG6 LdBPK_080230.1 ↔ LdBPK_300580.1 OG6 TCSYLVIO_003118 ↔ TCSYLVIO_010542 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_010542 OG7 LdBPK_080230.1 ↔ LdBPK_300580.1	Both
C4B63_85g75 ⚠ ubiquitin activating enzyme	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_010542 OG7 LdBPK_080230.1 ↔ LdBPK_300580.1	OG7
C4B63_2g566 phenylalanyl-tRNA synthetase	—	OG6 LdBPK_191010.1 ↔ LdBPK_300580.1 OG6 TCSYLVIO_003118 ↔ TCSYLVIO_005548 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_005548 OG7 LdBPK_191010.1 ↔ LdBPK_300580.1	Both
C4B63_41g128 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_300580.1	OG7
C4B63_168g16 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_003867 OG7 LdBPK_300580.1 ↔ LdBPK_342110.1	OG7
C4B63_43g202 ⚠ hook complex protein, conserved	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_005619 OG7 LdBPK_300580.1 ↔ LdBPK_332020.1	OG7
C4B63_224g16 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_300580.1	OG7
C4B63_42g203 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_003867 OG7 LdBPK_300580.1 ↔ LdBPK_342110.1	OG7
C4B63_41g122 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_300580.1	OG7
C4B63_41g125 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_300580.1	OG7
C4B63_31g99 WD repeat-containing protein 17	—	OG6 LdBPK_080420.1 ↔ LdBPK_300580.1 OG6 TCSYLVIO_003118 ↔ TCSYLVIO_010560 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_010560 OG7 LdBPK_080420.1 ↔ LdBPK_300580.1	Both
C4B63_41g119 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_006977 OG7 LdBPK_120255.1 ↔ LdBPK_300580.1	OG7
C4B63_42g202 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_003867 OG7 LdBPK_300580.1 ↔ LdBPK_342110.1	OG7
C4B63_271g10 ⚠ conserved hypothetical protein	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_005619 OG7 LdBPK_300580.1 ↔ LdBPK_332020.1	OG7
C4B63_102g61 ⚠ aspartyl-tRNA synthetase	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_003867 OG7 LdBPK_300580.1 ↔ LdBPK_342110.1	OG7
C4B63_7g79 ⚠ aspartyl-tRNA synthetase	—	OG6 LdBPK_300580.1 ↔ LdBPK_342110.1 OG6 TCSYLVIO_003118 ↔ TCSYLVIO_003867 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_003867 OG7 LdBPK_300580.1 ↔ LdBPK_342110.1	Both
C4B63_2g376 ⚠ ribosome assembly protein RRB1	—	OG6 LdBPK_300580.1 ↔ LdBPK_332020.1 OG6 TCSYLVIO_003118 ↔ TCSYLVIO_005619 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_005619 OG7 LdBPK_300580.1 ↔ LdBPK_332020.1	Both
C4B63_2g450 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG7 LdBPK_110640.1 ↔ LdBPK_300580.1	OG7
C4B63_193g9 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG6 LdBPK_110640.1 ↔ LdBPK_300580.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG7 LdBPK_110640.1 ↔ LdBPK_300580.1	Both
C4B63_70g129 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG6 LdBPK_110640.1 ↔ LdBPK_300580.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG7 LdBPK_110640.1 ↔ LdBPK_300580.1	Both
C4B63_12g153 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG6 LdBPK_110640.1 ↔ LdBPK_300580.1 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_003118 OG7 LdBPK_110640.1 ↔ LdBPK_300580.1	Both
C4B63_32g239 ⚠ tubulin folding cofactor D	—	OG6 LdBPK_242100.1 ↔ LdBPK_300580.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003118 OG7 LdBPK_242100.1 ↔ LdBPK_300580.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003118	Both
C4B63_32g238 ⚠ tubulin folding cofactor D	—	OG6 LdBPK_242100.1 ↔ LdBPK_300580.1 OG6 TCSYLVIO_001302 ↔ TCSYLVIO_003118 OG7 LdBPK_242100.1 ↔ LdBPK_300580.1 OG7 TCSYLVIO_001302 ↔ TCSYLVIO_003118	Both
C4B63_39g340 ⚠ replication factor C, subunit 4	—	OG7 LdBPK_241010.1 ↔ LdBPK_300580.1	OG7
C4B63_72g79 ⚠ inositol 5-phosphatase 1	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_007569 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_007569	Both
C4B63_12g219 ⚠ adaptin-related protein-like	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_004597	OG7
C4B63_44g232 ⚠ CRAL/TRIO domain containing protein	—	OG7 LdBPK_300580.1 ↔ LdBPK_310320.1	OG7
C4B63_2g203 ⚠ synaptojanin (N-terminal domain)	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_007569	OG7
C4B63_2g513 conserved hypothetical protein	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_005512 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_005512	Both
C4B63_15g18 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_003118 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_008502	Both
C4B63_54g57 vacuolar ATP synthase subunit d	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_005104 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_005104	Both
C4B63_24g190 ⚠ Exportin-7	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_003586 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_003586	Both
C4B63_40g106 ⚠ Adaptor protein complex AP-3 subunit beta-3	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_004597	OG7
C4B63_14g103 ⚠ beta adaptin	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_004597	OG7
C4B63_3g552 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_003118 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_008502	Both
C4B63_26g245 ⚠ inositol/phosphatidylinositol phosphatase	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_007569	OG7
C4B63_2g83 ⚠ ubiquitin hydrolase	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_005374	OG7
C4B63_13g257 ⚠ endonuclease/exonuclease/phosphatase	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_007569	OG7
C4B63_7g377 ⚠ [Pyruvate dehydrogenase (acetyl-transferring)	—	OG7 TCSYLVIO_003118 ↔ TCSYLVIO_007262 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_003118	OG7
C4B63_4g422 C-terminal motor kinesin	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_006065	OG6
C4B63_3g554 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_005159 OG6 TCSYLVIO_003118 ↔ TCSYLVIO_008502 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_005159 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_008502	Both
C4B63_21g30 ⚠ Exportin-7-A	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_003586 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_003586	Both
C4B63_85g64 DNA-damage inducible protein DDI1-like protei	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_003428 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_003428	Both
C4B63_42g49 Protein aardvark	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_003145 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_003145	Both
C4B63_2g748 conserved hypothetical protein	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_005810 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_005810	Both
C4B63_27g4 ⚠ ubiquitin ligase	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_006542 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_006542	Both
C4B63_7g417 snoRNP protein GAR1	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_003690 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_003690	Both
C4B63_297g14 ⚠ phenylalanyl-tRNA synthetase alpha chain	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_004213 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_004213	Both
C4B63_7g77 conserved hypothetical protein	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_003865 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_003865	Both
C4B63_3g1104 threonyl-tRNA synthetase	—	OG6 TCSYLVIO_003118 ↔ TCSYLVIO_007511 OG7 TCSYLVIO_003118 ↔ TCSYLVIO_007511	Both

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