C4B63_31g76

ubiquitin-activating enzyme
Trypanosoma cruzi Dm28c 2018 OG6: OG6_101769 OG7: OG7_0003569 155 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 155 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_42g187 ⚠
conserved hypothetical protein
— Both
C4B63_31g99 ⚠
WD repeat-containing protein 17
— Both
C4B63_2g376 ⚠
ribosome assembly protein RRB1
— Both
C4B63_22g161 ⚠
calpain-like cysteine peptidase
— OG6
C4B63_38g169 ⚠
calpain-like cysteine peptidase
— OG6
C4B63_22g164 ⚠
calpain-like cysteine peptidase
— OG6
C4B63_70g77 ⚠
acidocalcisomal pyrophosphatase
— Both
C4B63_23g248 ⚠
inorganic pyrophosphatase
— Both
C4B63_43g202 ⚠
hook complex protein, conserved
— OG7
C4B63_271g10 ⚠
conserved hypothetical protein
— OG7
C4B63_2g74 ⚠
poly(A)-specific ribonuclease PARN(fragment)
— OG7
C4B63_63g95 ⚠
poly(A)-specific ribonuclease PARN
— Both
C4B63_22g11 ⚠
developmentally regulated phosphoprotein
— Both
C4B63_24g190 ⚠
Exportin-7
— Both
C4B63_21g30 ⚠
Exportin-7-A
— Both
C4B63_107g4 ⚠
Rab3 GTPase-activating protein catalytic subu
— Both
C4B63_11g100 ⚠
Rab3 GTPase-activating protein catalytic subu
— Both
C4B63_39g359 ⚠
conserved hypothetical protein
— Both
C4B63_11g484 ⚠
Leucine Rich Repeat protein
— Both
C4B63_54g57 ⚠
vacuolar ATP synthase subunit d
— Both
C4B63_14g155 ⚠
Leucine-rich repeat-containing protein 74A
— Both
C4B63_10g522 ⚠
FACT complex subunit SPT16
— Both
C4B63_7g134 ⚠
conserved hypothetical protein
— Both
C4B63_21g259 ⚠
Small RNA degrading nuclease 5
— Both
C4B63_122g21 ⚠
ubiquitin ligase
— Both
C4B63_149g26 ⚠
GDP-mannose pyrophosphorylase
— Both
C4B63_27g4 ⚠
ubiquitin ligase
— Both
C4B63_32g239 ⚠
tubulin folding cofactor D
— Both
C4B63_32g238 ⚠
tubulin folding cofactor D
— Both
C4B63_2g450 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_41g119 ⚠
conserved hypothetical protein
— OG7
C4B63_41g125 ⚠
conserved hypothetical protein
— OG7
C4B63_41g122 ⚠
conserved hypothetical protein
— OG7
C4B63_224g16 ⚠
conserved hypothetical protein
— OG7
C4B63_41g128 ⚠
conserved hypothetical protein
— OG7
C4B63_45g121 ⚠
6-phosphofructo-2-kinase/fructose-2,6-biphosp
— OG7
C4B63_23g264 ⚠
6-phosphofructo-2-kinase 1
— OG7
C4B63_13g160 ⚠
6-phosphofructo-2-kinase/fructose-2,6-bisphos
— OG7
C4B63_2g203 ⚠
synaptojanin (N-terminal domain)
— OG7
C4B63_13g257 ⚠
endonuclease/exonuclease/phosphatase
— OG7
C4B63_26g245 ⚠
inositol/phosphatidylinositol phosphatase
— OG7
C4B63_20g38 ⚠
Synaptojanin
— OG7
C4B63_28g111 ⚠
synaptojanin
— OG7
C4B63_11g283c ⚠
U6 snRNA-associated Sm-like protein LSm8
— OG7
C4B63_2g83 ⚠
ubiquitin hydrolase
— OG7
C4B63_42g202 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_2g1123c ⚠
small nuclear ribonucleoprotein Sm-F
— OG7
C4B63_6g517 ⚠
geranylgeranyl transferase type II beta subun
— OG7
C4B63_54g82 ⚠
conserved hypothetical protein
— OG7
C4B63_8g190 ⚠
conserved hypothetical protein
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.