C4B63_21g259

Small RNA degrading nuclease 5

Trypanosoma cruzi Dm28c 2018 OG6: OG6_147025 OG7: OG7_0002372 101 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 101 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_7g417 snoRNP protein GAR1	—	OG6 TCSYLVIO_003690 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_003690 ↔ TCSYLVIO_010944	Both
C4B63_63g32 ⚠ adaptin-related protein-like	—	OG6 TCSYLVIO_004597 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_004597 ↔ TCSYLVIO_010944	Both
C4B63_193g9 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010944	Both
C4B63_70g129 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010944	Both
C4B63_12g153 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG6 TCSYLVIO_001670 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_001670 ↔ TCSYLVIO_010944	Both
C4B63_3g553 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_008502 ↔ TCSYLVIO_010944 OG6 TCSYLVIO_005159 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_008502 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_005159 ↔ TCSYLVIO_010944	Both
C4B63_15g18 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_008502 ↔ TCSYLVIO_010944 OG6 TCSYLVIO_005159 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_008502 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_005159 ↔ TCSYLVIO_010944	Both
C4B63_3g552 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_008502 ↔ TCSYLVIO_010944 OG6 TCSYLVIO_005159 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_008502 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_005159 ↔ TCSYLVIO_010944	Both
C4B63_3g550 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_008502 ↔ TCSYLVIO_010944 OG6 TCSYLVIO_005159 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_008502 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_005159 ↔ TCSYLVIO_010944	Both
C4B63_54g71 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_008502 ↔ TCSYLVIO_010944 OG6 TCSYLVIO_005159 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_008502 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_005159 ↔ TCSYLVIO_010944	Both
C4B63_15g19 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_008502 ↔ TCSYLVIO_010944 OG6 TCSYLVIO_005159 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_008502 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_005159 ↔ TCSYLVIO_010944	Both
C4B63_54g70 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_008502 ↔ TCSYLVIO_010944 OG6 TCSYLVIO_005159 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_008502 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_005159 ↔ TCSYLVIO_010944	Both
C4B63_3g554 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_008502 ↔ TCSYLVIO_010944 OG6 TCSYLVIO_005159 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_008502 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_005159 ↔ TCSYLVIO_010944	Both
C4B63_3g551 ⚠ NADH-dependent fumarate reductase	—	OG6 TCSYLVIO_008502 ↔ TCSYLVIO_010944 OG6 TCSYLVIO_005159 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_008502 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_005159 ↔ TCSYLVIO_010944	Both
C4B63_28g25 ⚠ pyruvate dehydrogenase (lipoamide) kinase	—	OG6 TCSYLVIO_001571 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_007262 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_001571 ↔ TCSYLVIO_010944	Both
C4B63_101g15 serine peptidase, Clan SC, Family S9B	—	OG6 TCSYLVIO_007536 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_007536 ↔ TCSYLVIO_010944	Both
C4B63_7g395 conserved hypothetical protein	—	OG6 TCSYLVIO_003707 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_003707 ↔ TCSYLVIO_010944	Both
C4B63_3g1104 threonyl-tRNA synthetase	—	OG6 TCSYLVIO_007511 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_007511 ↔ TCSYLVIO_010944	Both
C4B63_16g105 coronin	—	OG6 TCSYLVIO_000174 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_000174 ↔ TCSYLVIO_010944	Both
C4B63_2g566 phenylalanyl-tRNA synthetase	—	OG6 TCSYLVIO_005548 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_005548 ↔ TCSYLVIO_010944	Both
C4B63_4g422 C-terminal motor kinesin	—	OG6 TCSYLVIO_006065 ↔ TCSYLVIO_010944	OG6
C4B63_17g69 ⚠ phenylalanyl-tRNA synthetase alpha chain	—	OG6 TCSYLVIO_004213 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_004213 ↔ TCSYLVIO_010944	Both
C4B63_297g14 ⚠ phenylalanyl-tRNA synthetase alpha chain	—	OG6 TCSYLVIO_004213 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_004213 ↔ TCSYLVIO_010944	Both
C4B63_7g77 conserved hypothetical protein	—	OG6 TCSYLVIO_003865 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_003865 ↔ TCSYLVIO_010944	Both
C4B63_128g59 dihydrolipoamide branched chain transacylase	—	OG6 TCSYLVIO_009880 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_009880 ↔ TCSYLVIO_010944	Both
C4B63_42g221 kinesin	—	OG6 TCSYLVIO_003093 ↔ TCSYLVIO_010944	OG6
C4B63_43g126 ATP synthase F1 subunit gamma protein	—	OG6 TCSYLVIO_009375 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_009375 ↔ TCSYLVIO_010944	Both
C4B63_21g247 conserved hypothetical protein	—	OG6 TCSYLVIO_008446 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_008446 ↔ TCSYLVIO_010944	Both
C4B63_7g79 ⚠ aspartyl-tRNA synthetase	—	OG6 TCSYLVIO_003867 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_010944	Both
C4B63_4g342 ATP synthase mitochondrial F1 complex assembl	—	OG6 TCSYLVIO_006163 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_006163 ↔ TCSYLVIO_010944	Both
C4B63_31g99 WD repeat-containing protein 17	—	OG6 TCSYLVIO_010560 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_010560 ↔ TCSYLVIO_010944	Both
C4B63_70g126 conserved hypothetical protein	—	OG6 TCSYLVIO_001673 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_001673 ↔ TCSYLVIO_010944	Both
C4B63_22g164 ⚠ calpain-like cysteine peptidase	—	OG6 TCSYLVIO_007342 ↔ TCSYLVIO_010944	OG6
C4B63_38g169 ⚠ calpain-like cysteine peptidase	—	OG6 TCSYLVIO_007342 ↔ TCSYLVIO_010944	OG6
C4B63_22g161 ⚠ calpain-like cysteine peptidase	—	OG6 TCSYLVIO_007342 ↔ TCSYLVIO_010944	OG6
C4B63_2g513 conserved hypothetical protein	—	OG6 TCSYLVIO_005512 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_005512 ↔ TCSYLVIO_010944	Both
C4B63_2g748 conserved hypothetical protein	—	OG6 TCSYLVIO_005810 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_005810 ↔ TCSYLVIO_010944	Both
C4B63_8g540 ⚠ 6-phosphofructo-2-kinase/fructose-2,6-biphosp	—	OG6 TCSYLVIO_002376 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_002376 ↔ TCSYLVIO_010944	Both
C4B63_2g376 ⚠ ribosome assembly protein RRB1	—	OG6 TCSYLVIO_005619 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_005619 ↔ TCSYLVIO_010944	Both
C4B63_80g25 ⚠ ubiquitin hydrolase	—	OG6 TCSYLVIO_005374 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_005374 ↔ TCSYLVIO_010944	Both
C4B63_42g49 Protein aardvark	—	OG6 TCSYLVIO_003145 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_003145 ↔ TCSYLVIO_010944	Both
C4B63_10g522 FACT complex subunit SPT16	—	OG6 TCSYLVIO_010728 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_010728 ↔ TCSYLVIO_010944	Both
C4B63_7g134 conserved hypothetical protein	—	OG6 TCSYLVIO_010944 ↔ TCSYLVIO_010958 OG7 TCSYLVIO_010944 ↔ TCSYLVIO_010958	Both
C4B63_72g79 ⚠ inositol 5-phosphatase 1	—	OG6 TCSYLVIO_007569 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_007569 ↔ TCSYLVIO_010944	Both
C4B63_153g40 ⚠ inositol 5-phosphatase 1	—	OG6 TCSYLVIO_007569 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_007569 ↔ TCSYLVIO_010944	Both
C4B63_153g41 ⚠ inositol 5-phosphatase 1(fragment)	—	OG6 TCSYLVIO_007569 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_007569 ↔ TCSYLVIO_010944	Both
C4B63_83g73 ribonucleoprotein p18, mitochondrial precurso	—	OG6 TCSYLVIO_002426 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_002426 ↔ TCSYLVIO_010944	Both
C4B63_85g64 DNA-damage inducible protein DDI1-like protei	—	OG6 TCSYLVIO_003428 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_003428 ↔ TCSYLVIO_010944	Both
C4B63_32g256 ⚠ PFU (PLAA family ubiquitin binding)	—	OG6 TCSYLVIO_001314 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_001314 ↔ TCSYLVIO_010944	Both
C4B63_32g255 ⚠ WD domain, G-beta repeat	—	OG6 TCSYLVIO_001314 ↔ TCSYLVIO_010944 OG7 TCSYLVIO_001314 ↔ TCSYLVIO_010944	Both

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