C4B63_8g540

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_132778 OG7: OG7_0002306 186 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 186 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_2g799 ⚠
tRNA wybutosine-synthesizing protein 4
— OG7
C4B63_13g166 ⚠
leucine carboxyl methyltransferase
— OG7
C4B63_84g63 ⚠
conserved hypothetical protein
— OG7
C4B63_391g15 ⚠
conserved hypothetical protein
— OG7
C4B63_28g111 ⚠
synaptojanin
— OG7
C4B63_13g257 ⚠
endonuclease/exonuclease/phosphatase
— OG7
C4B63_2g83 ⚠
ubiquitin hydrolase
— OG7
C4B63_56g88 ⚠
Zinc finger C2HC domain-containing protein 1C
— OG7
C4B63_4g377 ⚠
Zinc finger protein 474
— OG7
C4B63_13g113 ⚠
zinc-finger of a C2HC-type
— OG7
C4B63_26g245 ⚠
inositol/phosphatidylinositol phosphatase
— OG7
C4B63_39g357 ⚠
ATP synthase
— OG7
C4B63_2g354 ⚠
isopentenyl-diphosphate delta-isomerase
— OG7
C4B63_4g378 ⚠
Zinc finger C2HC domain-containing protein 1C
— OG7
C4B63_42g202 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_41g119 ⚠
conserved hypothetical protein
— OG7
C4B63_14g103 ⚠
beta adaptin
— OG7
C4B63_54g80 ⚠
conserved hypothetical protein
— OG7
C4B63_25g120 ⚠
Protein kinase domain
— OG7
C4B63_4g577 ⚠
eukaryotic translation initiation factor 4E (
— OG7
C4B63_4g258 ⚠
prolyl-tRNA synthetase
— OG7
C4B63_40g106 ⚠
Adaptor protein complex AP-3 subunit beta-3
— OG7
C4B63_41g125 ⚠
conserved hypothetical protein
— OG7
C4B63_41g122 ⚠
conserved hypothetical protein
— OG7
C4B63_43g175 ⚠
2-oxoisovalerate dehydrogenase alpha subunit
— OG7
C4B63_52g51 ⚠
serine/threonine protein kinase
— OG7
C4B63_42g205 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
C4B63_14g144 ⚠
branch point binding protein
— OG7
C4B63_42g203 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_224g16 ⚠
conserved hypothetical protein
— OG7
C4B63_2g203 ⚠
synaptojanin (N-terminal domain)
— OG7
C4B63_43g202 ⚠
hook complex protein, conserved
— OG7
C4B63_168g16 ⚠
aspartyl-tRNA synthetase
— OG7
C4B63_42g204 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
C4B63_2g551 ⚠
Eukaryotic translation initiation factor 4E-1
— OG7
C4B63_52g128 ⚠
protein kinase
— OG7
C4B63_40g122 ⚠
vacuolar protein sorting-associated protein-l
— OG7
C4B63_19g264 ⚠
conserved hypothetical protein
— OG7
C4B63_310g13 ⚠
branch point binding protein
— OG7
C4B63_10g490 ⚠
Hsc70-interacting protein (Hip)
— OG7
C4B63_41g128 ⚠
conserved hypothetical protein
— OG7
C4B63_12g219 ⚠
adaptin-related protein-like
— OG7
C4B63_513g4 ⚠
eukaryotic translation initiation factor 4E (
— OG7
C4B63_85g75 ⚠
ubiquitin activating enzyme
— OG7
C4B63_20g38 ⚠
Synaptojanin
— OG7
C4B63_2g502 ⚠
ubiquitin carboxyl-terminal hydrolase
— OG7
C4B63_252g9 ⚠
ubiquitin carboxyl-terminal hydrolase
— OG7
C4B63_46g40 ⚠
conserved hypothetical protein
— OG7
C4B63_6g392 ⚠
leucine-rich repeat protein (LRRP)
— OG7
C4B63_28g59 ⚠
leucine-rich repeat protein (LRRP)
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.