C4B63_42g204

Eukaryotic translation initiation factor 4E-4
Trypanosoma cruzi Dm28c 2018 OG6: OG6_106272 OG7: OG7_0002303 250 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 250 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_57g94 ⚠
ATP-dependent RNA helicase
— OG7
C4B63_63g46 ⚠
2,3-bisphosphoglycerate-independent phosphogl
— OG7
C4B63_114g20 ⚠
C-1-tetrahydrofolate synthase, cytoplasmic
— OG7
C4B63_8g539 ⚠
C-1-tetrahydrofolate synthase, cytoplasmic
— OG7
C4B63_92g63 ⚠
KH domain/Domain of unknown function (DUF1771
— OG7
C4B63_69g28 ⚠
UBA/TS-N domain/CUE domain/Domain of unknown
— OG7
C4B63_208g34 ⚠
KH domain/Domain of unknown function (DUF1771
— OG7
C4B63_51g200 ⚠
mitochondrial DNA polymerase I protein B
— OG7
C4B63_55g69 ⚠
conserved hypothetical protein
— OG7
C4B63_55g68 ⚠
conserved hypothetical protein
— OG7
C4B63_6g257 ⚠
Vacuolar proton pump subunit B
— OG7
C4B63_6g258 ⚠
Vacuolar proton pump subunit B
— OG7
C4B63_41g128 ⚠
conserved hypothetical protein
— OG7
C4B63_224g16 ⚠
conserved hypothetical protein
— OG7
C4B63_41g122 ⚠
conserved hypothetical protein
— OG7
C4B63_41g125 ⚠
conserved hypothetical protein
— OG7
C4B63_41g119 ⚠
conserved hypothetical protein
— OG7
C4B63_30g245 ⚠
conserved hypothetical protein
— OG7
C4B63_23g269 ⚠
conserved hypothetical protein
— OG7
C4B63_24g191 ⚠
deoxyhypusine hydroxylase
— OG7
C4B63_243g4 ⚠
Present in the outer mitochondrial membrane p
— OG7
C4B63_42g67 ⚠
Protein F37C4.5
— OG7
C4B63_230g26 ⚠
tRNA threonylcarbamoyl adenosine modification
— OG7
C4B63_10g524 ⚠
nuclear transcription factor
— OG7
C4B63_13g189 ⚠
ubiquitin-like protein
— OG7
C4B63_19g259 ⚠
conserved hypothetical protein
— OG7
C4B63_56g64 ⚠
Present in the outer mitochondrial membrane p
— OG7
C4B63_6g385 ⚠
tRNA threonylcarbamoyl adenosine modification
— OG7
C4B63_142g6 ⚠
GMP synthase
— OG7
C4B63_238g18 ⚠
GMP synthase(fragment)
— OG7
C4B63_55g26 ⚠
conserved hypothetical protein
— OG7
C4B63_14g188 ⚠
UPF0769 protein C21orf59 homolog B
— OG7
C4B63_78g9 ⚠
conserved hypothetical protein
— OG7
C4B63_70g77 ⚠
acidocalcisomal pyrophosphatase
— OG7
C4B63_17g263 ⚠
phosphomannose isomerase
— OG7
C4B63_17g264 ⚠
phosphomannose isomerase
— OG7
C4B63_23g200 ⚠
Flagellum attachment zone protein 19
— OG7
C4B63_23g34 ⚠
quinone oxidoreductase
— OG7
C4B63_63g81 ⚠
protein transport protein Sec23A
— OG7
C4B63_34g318 ⚠
Vps51/Vps67
— OG7
C4B63_300g15 ⚠
Vps51/Vps67
— OG7
C4B63_9g488 ⚠
conserved hypothetical protein
— OG7
C4B63_7g361 ⚠
phosphomannomutase-like protein
— OG7
C4B63_300g16 ⚠
conserved hypothetical protein
— OG7
C4B63_35g125 ⚠
transaldolase
— OG7
C4B63_48g23 ⚠
nicotinate phosphoribosyltransferase
— OG7
C4B63_78g10 ⚠
conserved hypothetical protein
— OG7
C4B63_78g13 ⚠
Proteasome activator complex subunit 4
— OG7
C4B63_48g116 ⚠
5'-3' exoribonuclease D
— OG7
C4B63_25g220 ⚠
5'-3' exoribonuclease B
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.