C4B63_48g23

nicotinate phosphoribosyltransferase

Trypanosoma cruzi Dm28c 2018 OG6: OG6_109462 OG7: OG7_0015320 207 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 207 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_2g177 ⚠ UPF0652 protein	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_005744 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_005744	Both
C4B63_70g77 ⚠ acidocalcisomal pyrophosphatase	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_004898 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_004898	Both
C4B63_23g248 ⚠ inorganic pyrophosphatase	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_004898 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_004898	Both
C4B63_9g331 ⚠ transcription elongation factor s-II	—	OG6 TCSYLVIO_000382 ↔ TCSYLVIO_004898 OG7 TCSYLVIO_000382 ↔ TCSYLVIO_004898	Both
C4B63_112g17 conserved hypothetical protein	—	OG6 TCSYLVIO_001734 ↔ TCSYLVIO_004898 OG7 TCSYLVIO_001734 ↔ TCSYLVIO_004898	Both
C4B63_58g136 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_006832 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_006832	Both
C4B63_58g137 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_006832 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_006832	Both
C4B63_4g136 ⚠ N-myristoyl transferase	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_006126 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_006126	Both
C4B63_35g191 6-phosphogluconolactonase	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_007658 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_007658	Both
C4B63_4g357 Activator of 90 kDa heat shock protein ATPase	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_006151 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_006151	Both
C4B63_99g106 ⚠ monothiol glutaredoxin	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_007499 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_007499	Both
C4B63_241g7 ⚠ Leucine-rich repeat-containing protein 34	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_007538 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_007538	Both
C4B63_11g25 conserved hypothetical protein	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_006390 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_006390	Both
C4B63_20g213 ⚠ enoyl-CoA hydratase/isomerase family protein	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_005344 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_005344	Both
C4B63_188g43 conserved hypothetical protein	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_009863 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_009863	Both
C4B63_184g9 ⚠ protein phosphatase 2C	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_007482	OG6
C4B63_175g8 ⚠ TPR-repeat protein	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_009926	OG6
C4B63_4g383 ⚠ mevalonate-diphosphate decarboxylase	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_006134 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_006134	Both
C4B63_58g38 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_006876 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_006876	Both
C4B63_21g282 mitogen-activated protein kinase 3	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_007367	OG6
C4B63_31g228 ⚠ dihydroorotase	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_008471 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_008471	Both
C4B63_17g233 ⚠ iron superoxide dismutase	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_010549 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_010549	Both
C4B63_31g106 conserved hypothetical protein	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_010565 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_010565	Both
C4B63_14g782c ⚠ monothiol glutaredoxin	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_007499 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_007499	Both
C4B63_25g240 Macro domain containing protein	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_008897 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_008897	Both
C4B63_227g9 ⚠ mevalonate-diphosphate decarboxylase	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_006134 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_006134	Both
C4B63_2g294 40 kDa cyclophilin	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_005686	OG6
C4B63_24g272 ⚠ Zn-finger in Ran binding protein and others/S	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_005185 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_005185	Both
C4B63_2g486 ⚠ Serine-threonine kinase receptor-associated p	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_005499 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_005499	Both
C4B63_31g85 ⚠ iron superoxide dismutase A, mitochondrial	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_010549 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_010549	Both
C4B63_13g192 ⚠ Elongation factor G1, mitochondrial	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_007487 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_007487	Both
C4B63_60g80 ⚠ dihydroorotase	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_008471 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_008471	Both
C4B63_20g212 ⚠ enoyl-CoA hydratase/isomerase family protein	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_005344 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_005344	Both
C4B63_4g146 ⚠ pyruvate kinase 2	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_006133 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_006133	Both
C4B63_227g20 ⚠ pyruvate kinase 2	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_006133 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_006133	Both
C4B63_24g273 ⚠ Probable E3 ubiquitin-protein ligase HERC1	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_005185 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_005185	Both
C4B63_80g53 ⚠ iron superoxide dismutase	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_010549 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_010549	Both
C4B63_392g17 ⚠ iron superoxide dismutase	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_010549 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_010549	Both
C4B63_47g40 ⚠ CS domain containing protein	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_005716 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_005716	Both
C4B63_219g55 ⚠ Leucine-rich repeat-containing protein 34	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_007538 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_007538	Both
C4B63_90g47 ⚠ UPF0652 protein	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_005744 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_005744	Both
C4B63_10g488 UBX domain-containing protein	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_010701 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_010701	Both
C4B63_148g27 ⚠ iron superoxide dismutase	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_010549 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_010549	Both
C4B63_7g133 pyroglutamyl-peptidase I	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_010957	Both
C4B63_13g230 Eukaryotic translation initiation factor 6	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_009989 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_009989	Both
C4B63_219g40 ⚠ Leucine-rich repeat-containing protein	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_007538 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_007538	Both
C4B63_79g87 phosphoglucomutase	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_007974 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_007974	Both
C4B63_4g226 UTP-glucose-1-phosphate uridylyltransferase 2	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_006226 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_006226	Both
C4B63_89g43 PITH domain-containing protein	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_007000 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_007000	Both
C4B63_259g9 ⚠ Ran-binding protein	—	OG6 TCSYLVIO_000197 ↔ TCSYLVIO_004898 OG7 TCSYLVIO_000197 ↔ TCSYLVIO_004898	Both

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