C4B63_4g226

UTP-glucose-1-phosphate uridylyltransferase 2

Trypanosoma cruzi Dm28c 2018 OG6: OG6_102276 OG7: OG7_0005733 189 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 189 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_144g30 ⚠ Kinesin-13 1	—	OG7 TCSYLVIO_001515 ↔ TCSYLVIO_006226	OG7
C4B63_279g8 ⚠ ubiquitin carboxyl-terminal hydrolase	—	OG6 TCSYLVIO_002972 ↔ TCSYLVIO_006226 OG7 TCSYLVIO_002972 ↔ TCSYLVIO_006226	Both
C4B63_19g259 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005459 ↔ TCSYLVIO_006226 OG7 TCSYLVIO_005459 ↔ TCSYLVIO_006226	Both
C4B63_48g23 nicotinate phosphoribosyltransferase	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_006226 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_006226	Both
C4B63_9g331 ⚠ transcription elongation factor s-II	—	OG6 TCSYLVIO_000382 ↔ TCSYLVIO_006226 OG7 TCSYLVIO_000382 ↔ TCSYLVIO_006226	Both
C4B63_23g248 ⚠ inorganic pyrophosphatase	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006226 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006226	Both
C4B63_70g77 ⚠ acidocalcisomal pyrophosphatase	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_006226 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_006226	Both
C4B63_19g185 ⚠ isocitrate dehydrogenase	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_010946 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_010946	Both
C4B63_4g180 ⚠ serine/threonine protein kinase	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_009716 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_009716	Both
C4B63_11g29 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldola	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_006387 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_006387	Both
C4B63_13g109 ⚠ protein phosphatase 2C-like	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_007482	OG6
C4B63_45g139 ⚠ serine/threonine protein kinase	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_009716 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_009716	Both
C4B63_39g342 phosphoenolpyruvate mutase	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_009212 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_009212	Both
C4B63_27g229 cyclin 1	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_006512 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_006512	Both
C4B63_39g304 ⚠ NUDIX hydrolase 3	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_009243 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_009243	Both
C4B63_21g253 Mitogen-activated protein kinase 10	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_010938	OG6
C4B63_52g143 Bifunctional NAD(P)H-hydrate repair enzyme	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_010611 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_010611	Both
C4B63_134g36 ⚠ dihydroorotase	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_008471 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_008471	Both
C4B63_184g38 ⚠ TPR-repeat protein	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_009926	OG6
C4B63_35g129 ⚠ dihydroorotase	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_008471 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_008471	Both
C4B63_40g25 Biotin--acetyl-CoA-carboxylase ligase	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_008176 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_008176	Both
C4B63_26g204 phosphomevalonate kinase protein	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_007028 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_007028	Both
C4B63_13g167 ⚠ stress-inducible protein STI1-like	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_009926	OG6
C4B63_21g261 ⚠ isocitrate dehydrogenase [NADP], mitochondria	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_010946 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_010946	Both
C4B63_132g66 ⚠ NUDIX hydrolase 3	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_009243 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_009243	Both
C4B63_17g249 ⚠ protein phosphatase 2C	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_007482	OG6
C4B63_10g437 U-box domain protein	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_010665 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_010665	Both
C4B63_22g64 ⚠ Poly(A) RNA polymerase GLD2-A	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_007293 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_007293	Both
C4B63_3g1122 ⚠ choline/ethanolamine kinase	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_007612 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_007612	Both
C4B63_12g300 TAP42-like family	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_006262 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_006262	Both
C4B63_13g192 ⚠ Elongation factor G1, mitochondrial	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_007487 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_007487	Both
C4B63_60g80 ⚠ dihydroorotase	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_008471 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_008471	Both
C4B63_89g43 PITH domain-containing protein	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_007000 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_007000	Both
C4B63_79g87 phosphoglucomutase	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_007974 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_007974	Both
C4B63_21g264 ⚠ protein transport protein SEC23	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_010948 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_010948	Both
C4B63_13g230 Eukaryotic translation initiation factor 6	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_009989 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_009989	Both
C4B63_7g133 pyroglutamyl-peptidase I	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_010957	Both
C4B63_10g488 UBX domain-containing protein	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_010701 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_010701	Both
C4B63_3g1118 ⚠ choline/ethanolamine kinase	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_007612 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_007612	Both
C4B63_31g106 conserved hypothetical protein	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_010565 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_010565	Both
C4B63_31g228 ⚠ dihydroorotase	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_008471 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_008471	Both
C4B63_58g38 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_006876 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_006876	Both
C4B63_175g8 ⚠ TPR-repeat protein	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_009926	OG6
C4B63_184g9 ⚠ protein phosphatase 2C	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_007482	OG6
C4B63_188g43 conserved hypothetical protein	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_009863 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_009863	Both
C4B63_11g25 conserved hypothetical protein	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_006390 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_006390	Both
C4B63_11g76 molecular chaperone HscB	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_006355 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_006355	Both
C4B63_35g191 6-phosphogluconolactonase	—	OG6 TCSYLVIO_006226 ↔ TCSYLVIO_007658 OG7 TCSYLVIO_006226 ↔ TCSYLVIO_007658	Both
C4B63_54g35 ⚠ protein kinase	—	OG7 TCSYLVIO_006226 ↔ TCSYLVIO_009716	OG7
C4B63_13g231 ⚠ serine/threonine protein kinase	—	OG7 TCSYLVIO_006226 ↔ TCSYLVIO_009716	OG7

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