C4B63_21g253

Mitogen-activated protein kinase 10
Trypanosoma cruzi Dm28c 2018 OG6: OG6_147455 OG7: OG7_0000396 167 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 167 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_114g23
UBX domain-containing protein 3
— OG6
C4B63_47g40 ⚠
CS domain containing protein
— OG6
C4B63_2g235 ⚠
Co-chaperone protein P23
— OG6
C4B63_35g191
6-phosphogluconolactonase
— OG6
C4B63_20g212 ⚠
enoyl-CoA hydratase/isomerase family protein
— OG6
C4B63_20g213 ⚠
enoyl-CoA hydratase/isomerase family protein
— OG6
C4B63_52g143
Bifunctional NAD(P)H-hydrate repair enzyme
— OG6
C4B63_227g9 ⚠
mevalonate-diphosphate decarboxylase
— OG6
C4B63_4g383 ⚠
mevalonate-diphosphate decarboxylase
— OG6
C4B63_4g180 ⚠
serine/threonine protein kinase
— OG6
C4B63_188g43
conserved hypothetical protein
— OG6
C4B63_45g139 ⚠
serine/threonine protein kinase
— OG6
C4B63_40g25
Biotin--acetyl-CoA-carboxylase ligase
— OG6
C4B63_10g488
UBX domain-containing protein
— OG6
C4B63_4g357
Activator of 90 kDa heat shock protein ATPase
— OG6
C4B63_18g278
RNA-binding protein
— OG6
C4B63_253g15 ⚠
haloacid dehalogenase-like hydrolase
— OG6
C4B63_54g69 ⚠
aspartate aminotransferase
— OG6
C4B63_6g146 ⚠
haloacid dehalogenase-like hydrolase
— OG6
C4B63_28g64 ⚠
aspartate aminotransferase
— OG6
C4B63_6g148 ⚠
haloacid dehalogenase-like hydrolase
— OG6
C4B63_10g148 ⚠
carnitine/choline acetyltransferase
— OG6
C4B63_10g147 ⚠
carnitine O-acetyltransferase(fragment)
— OG6
C4B63_25g240
Macro domain containing protein
— OG6
C4B63_17g73 ⚠
Probable protein phosphatase methylesterase 1
— OG6
C4B63_18g30
epsilon-adaptin
— OG6
C4B63_297g19 ⚠
Protein phosphatase methylesterase 1
— OG6
C4B63_17g99
exportin 1
— OG6
C4B63_11g25
conserved hypothetical protein
— OG6
C4B63_9g201 ⚠
GTP-binding protein
— OG6
C4B63_184g8 ⚠
GTP-binding protein
— OG6
C4B63_7g361
phosphomannomutase-like protein
— OG6
C4B63_17g188
Phosphopantetheine adenylyltransferase
— OG6
C4B63_30g144
Cilia- and flagella-associated protein 52
— OG6
C4B63_184g38 ⚠
TPR-repeat protein
— OG6
C4B63_13g167 ⚠
stress-inducible protein STI1-like
— OG6
C4B63_175g8 ⚠
TPR-repeat protein
— OG6
C4B63_40g46
ATP-dependent protease subunit HslV
— OG6
C4B63_42g217
protein phosphatase
— OG6
C4B63_17g249 ⚠
protein phosphatase 2C
— OG6
C4B63_16g163
Pyridoxal phosphate homeostasis protein
— OG6
C4B63_30g145
electron-transfer-flavoprotein, alpha polypep
— OG6
C4B63_279g8 ⚠
ubiquitin carboxyl-terminal hydrolase
— OG6
C4B63_9g331
transcription elongation factor s-II
— OG6
C4B63_112g17
conserved hypothetical protein
— OG6
C4B63_48g23
nicotinate phosphoribosyltransferase
— OG6
C4B63_19g259
conserved hypothetical protein
— OG6
C4B63_47g80
Gamma-soluble NSF attachment protein
— OG6
C4B63_35g129 ⚠
dihydroorotase
— OG6
C4B63_44g252 ⚠
ubiquitin carboxyl-terminal hydrolase
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.