C4B63_54g69

aspartate aminotransferase

Trypanosoma cruzi Dm28c 2018 OG6: OG6_100337 OG7: OG7_0003266 198 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 198 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_170g15 ⚠ aminopeptidase	—	OG6 Tb927.11.3570 ↔ Tb927.11.5090 OG7 Tb927.11.3570 ↔ Tb927.11.5090 OG7 TCSYLVIO_005115 ↔ TCSYLVIO_007446	Both
C4B63_46g74 ⚠ aminopeptidase	—	OG6 Tb927.11.3570 ↔ Tb927.11.5090 OG7 Tb927.11.3570 ↔ Tb927.11.5090 OG7 TCSYLVIO_005115 ↔ TCSYLVIO_007446	Both
C4B63_23g83 ⚠ Aminopeptidase M1	—	OG6 TCSYLVIO_005115 ↔ TCSYLVIO_007446 OG7 Tb927.11.3570 ↔ Tb927.11.5090 OG7 TCSYLVIO_005115 ↔ TCSYLVIO_007446	Both
C4B63_41g246 ⚠ puromycin-sensitive aminopeptidase-like prote	—	OG7 Tb927.11.3570 ↔ Tb927.11.5090 OG7 TCSYLVIO_005115 ↔ TCSYLVIO_007446	OG7
C4B63_41g245 ⚠ puromycin-sensitive aminopeptidase-like prote	—	OG7 Tb927.11.3570 ↔ Tb927.11.5090 OG7 TCSYLVIO_005115 ↔ TCSYLVIO_007446	OG7
C4B63_4g383 ⚠ mevalonate-diphosphate decarboxylase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_006134 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_006134	Both
C4B63_163g21 ⚠ deoxyribose-phosphate aldolase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_001881 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_001881	Both
C4B63_279g8 ⚠ ubiquitin carboxyl-terminal hydrolase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_002972 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_002972	Both
C4B63_42g174 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_003130 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_003130	Both
C4B63_243g4 ⚠ Present in the outer mitochondrial membrane p	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_003157 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_003157	Both
C4B63_17g188 ⚠ Phosphopantetheine adenylyltransferase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_004096 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_004096	Both
C4B63_35g191 ⚠ 6-phosphogluconolactonase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_007658 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_007658	Both
C4B63_4g136 ⚠ N-myristoyl transferase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_006126 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_006126	Both
C4B63_4g357 ⚠ Activator of 90 kDa heat shock protein ATPase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_006151 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_006151	Both
C4B63_6g148 ⚠ haloacid dehalogenase-like hydrolase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_002576 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_002576	Both
C4B63_69g27 ⚠ 35 kDa cyclophilin	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_003462	OG6
C4B63_92g63 ⚠ KH domain/Domain of unknown function (DUF1771	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_002786 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_002786	Both
C4B63_25g317 ⚠ threonine synthase	—	OG6 TCSYLVIO_005115 ↔ TCSYLVIO_010337 OG7 TCSYLVIO_005115 ↔ TCSYLVIO_010337	Both
C4B63_10g147 ⚠ carnitine O-acetyltransferase(fragment)	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_004300	OG6
C4B63_14g17 ⚠ small G-protein	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_004644	OG6
C4B63_20g213 ⚠ enoyl-CoA hydratase/isomerase family protein	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_005344 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_005344	Both
C4B63_246g7 ⚠ Gastrulation defective protein 1 homolog	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_004877 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_004877	Both
C4B63_11g25 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_006390 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_006390	Both
C4B63_188g43 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_009863 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_009863	Both
C4B63_184g9 ⚠ protein phosphatase 2C	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_007482	OG6
C4B63_175g8 ⚠ TPR-repeat protein	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_009926	OG6
C4B63_44g104 ⚠ diphthine synthase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_002908 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_002908	Both
C4B63_6g146 ⚠ haloacid dehalogenase-like hydrolase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_002576 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_002576	Both
C4B63_7g133 ⚠ pyroglutamyl-peptidase I	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_010957	Both
C4B63_10g488 ⚠ UBX domain-containing protein	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_010701 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_010701	Both
C4B63_48g23 ⚠ nicotinate phosphoribosyltransferase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_004898 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_004898	Both
C4B63_227g9 ⚠ mevalonate-diphosphate decarboxylase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_006134 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_006134	Both
C4B63_90g47 ⚠ UPF0652 protein	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_005744 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_005744	Both
C4B63_2g177 ⚠ UPF0652 protein	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_005744 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_005744	Both
C4B63_23g269 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_004472 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_004472	Both
C4B63_17g264 ⚠ phosphomannose isomerase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_004145 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_004145	Both
C4B63_44g252 ⚠ ubiquitin carboxyl-terminal hydrolase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_002972 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_002972	Both
C4B63_52g141 ⚠ poly(A) polymerase	—	OG6 TCSYLVIO_005115 ↔ TCSYLVIO_010610 OG7 TCSYLVIO_005115 ↔ TCSYLVIO_010610	Both
C4B63_31g106 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_010565 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_010565	Both
C4B63_9g488 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_004051 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_004051	Both
C4B63_31g228 ⚠ dihydroorotase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_008471 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_008471	Both
C4B63_58g38 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_006876 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_006876	Both
C4B63_4g324 ⚠ aconitase	—	OG6 TCSYLVIO_005115 ↔ TCSYLVIO_006177 OG7 TCSYLVIO_005115 ↔ TCSYLVIO_006177	Both
C4B63_230g26 ⚠ tRNA threonylcarbamoyl adenosine modification	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_002651 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_002651	Both
C4B63_129g42 ⚠ diphthine synthase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_002908 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_002908	Both
C4B63_140g30 ⚠ diphthine synthase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_002908 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_002908	Both
C4B63_125g66 ⚠ Mucin-associated surface protein (MASP)	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_002495	OG6
C4B63_26g278 ⚠ arginine kinase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_007077 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_007077	Both
C4B63_3g686 ⚠ Mucin-associated surface protein (MASP)	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_002495	OG6
C4B63_70g77 ⚠ acidocalcisomal pyrophosphatase	—	OG6 TCSYLVIO_001538 ↔ TCSYLVIO_004455 OG7 TCSYLVIO_001538 ↔ TCSYLVIO_004455	Both

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