C4B63_31g228

dihydroorotase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_101673 OG7: OG7_0002356 158 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
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Interactions 158 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_144g30 ⚠
Kinesin-13 1
— OG7
C4B63_184g9 ⚠
protein phosphatase 2C
— OG6
C4B63_30g145 ⚠
electron-transfer-flavoprotein, alpha polypep
— Both
C4B63_16g163 ⚠
Pyridoxal phosphate homeostasis protein
— Both
C4B63_114g23 ⚠
UBX domain-containing protein 3
— Both
C4B63_13g192 ⚠
Elongation factor G1, mitochondrial
— Both
C4B63_23g200 ⚠
Flagellum attachment zone protein 19
— Both
C4B63_6g385 ⚠
tRNA threonylcarbamoyl adenosine modification
— Both
C4B63_230g26 ⚠
tRNA threonylcarbamoyl adenosine modification
— Both
C4B63_69g27 ⚠
35 kDa cyclophilin
— OG6
C4B63_22g64 ⚠
Poly(A) RNA polymerase GLD2-A
— Both
C4B63_58g38 ⚠
conserved hypothetical protein
— Both
C4B63_4g137 ⚠
N-myristoyl transferase
— Both
C4B63_4g136 ⚠
N-myristoyl transferase
— Both
C4B63_14g37 ⚠
conserved hypothetical protein
— Both
C4B63_19g185 ⚠
isocitrate dehydrogenase
— Both
C4B63_4g180 ⚠
serine/threonine protein kinase
— Both
C4B63_45g139 ⚠
serine/threonine protein kinase
— Both
C4B63_39g342 ⚠
phosphoenolpyruvate mutase
— Both
C4B63_52g143 ⚠
Bifunctional NAD(P)H-hydrate repair enzyme
— Both
C4B63_21g253 ⚠
Mitogen-activated protein kinase 10
— OG6
C4B63_184g38 ⚠
TPR-repeat protein
— OG6
C4B63_13g167 ⚠
stress-inducible protein STI1-like
— OG6
C4B63_21g261 ⚠
isocitrate dehydrogenase [NADP], mitochondria
— Both
C4B63_10g437 ⚠
U-box domain protein
— Both
C4B63_13g230 ⚠
Eukaryotic translation initiation factor 6
— Both
C4B63_7g133 ⚠
pyroglutamyl-peptidase I
— Both
C4B63_10g488 ⚠
UBX domain-containing protein
— Both
C4B63_31g106 ⚠
conserved hypothetical protein
— Both
C4B63_175g8 ⚠
TPR-repeat protein
— OG6
C4B63_188g43 ⚠
conserved hypothetical protein
— Both
C4B63_44g252 ⚠
ubiquitin carboxyl-terminal hydrolase
— Both
C4B63_279g8 ⚠
ubiquitin carboxyl-terminal hydrolase
— Both
C4B63_19g259 ⚠
conserved hypothetical protein
— Both
C4B63_48g23 ⚠
nicotinate phosphoribosyltransferase
— Both
C4B63_9g331 ⚠
transcription elongation factor s-II
— Both
C4B63_23g248 ⚠
inorganic pyrophosphatase
— Both
C4B63_70g77 ⚠
acidocalcisomal pyrophosphatase
— Both
C4B63_4g226 ⚠
UTP-glucose-1-phosphate uridylyltransferase 2
— Both
C4B63_89g43 ⚠
PITH domain-containing protein
— Both
C4B63_54g35 ⚠
protein kinase
— OG7
C4B63_114g20 ⚠
C-1-tetrahydrofolate synthase, cytoplasmic
— OG7
C4B63_69g28 ⚠
UBA/TS-N domain/CUE domain/Domain of unknown
— OG7
C4B63_13g41 ⚠
protein kinase
— OG7
C4B63_6g391 ⚠
protein kinase
— OG7
C4B63_13g231 ⚠
serine/threonine protein kinase
— OG7
C4B63_58g54 ⚠
serine/threonine protein kinase
— OG7
C4B63_23g122 ⚠
serine/threonine protein kinase
— OG7
C4B63_28g48 ⚠
transcription elongation factor
— OG7
C4B63_76g131 ⚠
protein kinase
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.