C4B63_114g20

C-1-tetrahydrofolate synthase, cytoplasmic
Trypanosoma cruzi Dm28c 2018 OG6: OG6_200158 OG7: OG7_0002739 181 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 181 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_31g106 ⚠
conserved hypothetical protein
— OG7
C4B63_282g13 ⚠
Elongation factor G 2, mitochondrial
— OG7
C4B63_43g124 ⚠
RNA polymerase II
— OG7
C4B63_39g342 ⚠
phosphoenolpyruvate mutase
— OG7
C4B63_267g13 ⚠
Nuclear protein localization protein 4 homolo
— OG7
C4B63_4g577 ⚠
eukaryotic translation initiation factor 4E (
— OG7
C4B63_225g44 ⚠
conserved hypothetical protein
— OG7
C4B63_110g27 ⚠
Leucine-rich repeat-containing protein 34
— OG7
C4B63_69g55 ⚠
monothiol glutaredoxin
— OG7
C4B63_52g143 ⚠
Bifunctional NAD(P)H-hydrate repair enzyme
— OG7
C4B63_4g348 ⚠
Bifunctional coenzyme A synthase
— OG7
C4B63_42g205 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
C4B63_297g19 ⚠
Protein phosphatase methylesterase 1
— OG7
C4B63_48g116 ⚠
5'-3' exoribonuclease D
— OG7
C4B63_3g1086 ⚠
monothiol glutaredoxin
— OG7
C4B63_208g34 ⚠
KH domain/Domain of unknown function (DUF1771
— OG7
C4B63_2g396 ⚠
conserved hypothetical protein
— OG7
C4B63_134g36 ⚠
dihydroorotase
— OG7
C4B63_112g33 ⚠
haloacid dehalogenase hydrolase
— OG7
C4B63_84g37 ⚠
Gastrulation defective protein 1 homolog
— OG7
C4B63_7g361 ⚠
phosphomannomutase-like protein
— OG7
C4B63_58g37 ⚠
conserved hypothetical protein
— OG7
C4B63_17g263 ⚠
phosphomannose isomerase
— OG7
C4B63_17g82 ⚠
ubiquitin-conjugating enzyme E2
— OG7
C4B63_18g151 ⚠
conserved hypothetical protein
— OG7
C4B63_12g315 ⚠
Nuclear protein localization protein 4 homolo
— OG7
C4B63_23g122 ⚠
serine/threonine protein kinase
— OG7
C4B63_40g25 ⚠
Biotin--acetyl-CoA-carboxylase ligase
— OG7
C4B63_35g129 ⚠
dihydroorotase
— OG7
C4B63_42g204 ⚠
Eukaryotic translation initiation factor 4E-4
— OG7
C4B63_2g551 ⚠
Eukaryotic translation initiation factor 4E-1
— OG7
C4B63_42g67 ⚠
Protein F37C4.5
— OG7
C4B63_13g231 ⚠
serine/threonine protein kinase
— OG7
C4B63_10g488 ⚠
UBX domain-containing protein
— OG7
C4B63_48g23 ⚠
nicotinate phosphoribosyltransferase
— OG7
C4B63_227g9 ⚠
mevalonate-diphosphate decarboxylase
— OG7
C4B63_90g47 ⚠
UPF0652 protein
— OG7
C4B63_2g177 ⚠
UPF0652 protein
— OG7
C4B63_148g27 ⚠
iron superoxide dismutase
— OG7
C4B63_23g269 ⚠
conserved hypothetical protein
— OG7
C4B63_17g264 ⚠
phosphomannose isomerase
— OG7
C4B63_44g252 ⚠
ubiquitin carboxyl-terminal hydrolase
— OG7
C4B63_25g240 ⚠
Macro domain containing protein
— OG7
C4B63_14g782c ⚠
monothiol glutaredoxin
— OG7
C4B63_396g15 ⚠
Spindle assembly abnormal protein 6 homolog
— OG7
C4B63_47g80 ⚠
Gamma-soluble NSF attachment protein
— OG7
C4B63_35g191 ⚠
6-phosphogluconolactonase
— OG7
C4B63_99g106 ⚠
monothiol glutaredoxin
— OG7
C4B63_4g357 ⚠
Activator of 90 kDa heat shock protein ATPase
— OG7
C4B63_7g383 ⚠
epsilon-adaptin
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.