C4B63_89g43

PITH domain-containing protein

Trypanosoma cruzi Dm28c 2018 OG6: OG6_102988 OG7: OG7_0006444 239 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 239 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_6g148 ⚠ haloacid dehalogenase-like hydrolase	—	OG6 LdBPK_120020.1 ↔ LdBPK_281480.1 OG6 TCSYLVIO_002576 ↔ TCSYLVIO_007000 OG7 LdBPK_120020.1 ↔ LdBPK_281480.1 OG7 LdBPK_120020.1 ↔ LdBPK_281470.1 +1 more	Both
C4B63_6g146 ⚠ haloacid dehalogenase-like hydrolase	—	OG6 LdBPK_120020.1 ↔ LdBPK_281480.1 OG6 TCSYLVIO_002576 ↔ TCSYLVIO_007000 OG7 LdBPK_120020.1 ↔ LdBPK_281480.1 OG7 LdBPK_120020.1 ↔ LdBPK_281470.1 +1 more	Both
C4B63_253g15 ⚠ haloacid dehalogenase-like hydrolase	—	OG6 LdBPK_120020.1 ↔ LdBPK_281480.1 OG6 TCSYLVIO_002576 ↔ TCSYLVIO_007000 OG7 LdBPK_120020.1 ↔ LdBPK_281480.1 OG7 LdBPK_120020.1 ↔ LdBPK_281470.1 +1 more	Both
C4B63_112g33 ⚠ haloacid dehalogenase hydrolase	—	OG7 LdBPK_120020.1 ↔ LdBPK_281480.1 OG7 LdBPK_120020.1 ↔ LdBPK_281470.1 OG7 TCSYLVIO_002576 ↔ TCSYLVIO_007000	OG7
C4B63_30g112 ⚠ haloacid dehalogenase hydrolase	—	OG7 LdBPK_120020.1 ↔ LdBPK_281480.1 OG7 LdBPK_120020.1 ↔ LdBPK_281470.1 OG7 TCSYLVIO_002576 ↔ TCSYLVIO_007000	OG7
C4B63_14g35 Sucrase/ferredoxin-like	—	OG6 LdBPK_120020.1 ↔ LdBPK_366440.1 OG6 TCSYLVIO_004651 ↔ TCSYLVIO_007000 OG7 LdBPK_120020.1 ↔ LdBPK_366440.1 OG7 TCSYLVIO_004651 ↔ TCSYLVIO_007000	Both
C4B63_184g38 ⚠ TPR-repeat protein	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_009926	OG6
C4B63_31g228 ⚠ dihydroorotase	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_008471 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_008471	Both
C4B63_17g233 ⚠ iron superoxide dismutase	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_010549 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_010549	Both
C4B63_31g106 conserved hypothetical protein	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_010565 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_010565	Both
C4B63_14g782c ⚠ monothiol glutaredoxin	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_007499 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_007499	Both
C4B63_25g240 Macro domain containing protein	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_008897 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_008897	Both
C4B63_10g488 UBX domain-containing protein	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_010701 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_010701	Both
C4B63_148g27 ⚠ iron superoxide dismutase	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_010549 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_010549	Both
C4B63_7g133 pyroglutamyl-peptidase I	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_010957 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_010957	Both
C4B63_13g230 Eukaryotic translation initiation factor 6	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_009989 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_009989	Both
C4B63_219g40 ⚠ Leucine-rich repeat-containing protein	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_007538 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_007538	Both
C4B63_219g55 ⚠ Leucine-rich repeat-containing protein 34	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_007538 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_007538	Both
C4B63_236g16 ⚠ Leucine-rich repeat-containing protein 34	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_007538 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_007538	Both
C4B63_79g87 phosphoglucomutase	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_007974 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_007974	Both
C4B63_392g17 ⚠ iron superoxide dismutase	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_010549 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_010549	Both
C4B63_80g53 ⚠ iron superoxide dismutase	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_010549 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_010549	Both
C4B63_60g80 ⚠ dihydroorotase	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_008471 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_008471	Both
C4B63_13g192 ⚠ Elongation factor G1, mitochondrial	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_007487 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_007487	Both
C4B63_31g85 ⚠ iron superoxide dismutase A, mitochondrial	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_010549 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_010549	Both
C4B63_22g64 ⚠ Poly(A) RNA polymerase GLD2-A	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_007293 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_007293	Both
C4B63_10g437 U-box domain protein	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_010665 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_010665	Both
C4B63_17g249 ⚠ protein phosphatase 2C	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_007482	OG6
C4B63_21g261 ⚠ isocitrate dehydrogenase [NADP], mitochondria	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_010946 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_010946	Both
C4B63_13g167 ⚠ stress-inducible protein STI1-like	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_009926	OG6
C4B63_40g25 Biotin--acetyl-CoA-carboxylase ligase	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_008176 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_008176	Both
C4B63_35g129 ⚠ dihydroorotase	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_008471 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_008471	Both
C4B63_9g216 ⚠ esterase	—	OG6 TCSYLVIO_000457 ↔ TCSYLVIO_007000 OG7 TCSYLVIO_000457 ↔ TCSYLVIO_007000	Both
C4B63_6g385 ⚠ tRNA threonylcarbamoyl adenosine modification	—	OG6 TCSYLVIO_002651 ↔ TCSYLVIO_007000 OG7 TCSYLVIO_002651 ↔ TCSYLVIO_007000	Both
C4B63_230g26 ⚠ tRNA threonylcarbamoyl adenosine modification	—	OG6 TCSYLVIO_002651 ↔ TCSYLVIO_007000 OG7 TCSYLVIO_002651 ↔ TCSYLVIO_007000	Both
C4B63_69g27 35 kDa cyclophilin	—	OG6 TCSYLVIO_003462 ↔ TCSYLVIO_007000	OG6
C4B63_58g38 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_006876 ↔ TCSYLVIO_007000 OG7 TCSYLVIO_006876 ↔ TCSYLVIO_007000	Both
C4B63_4g137 ⚠ N-myristoyl transferase	—	OG6 TCSYLVIO_006126 ↔ TCSYLVIO_007000 OG7 TCSYLVIO_006126 ↔ TCSYLVIO_007000	Both
C4B63_4g136 ⚠ N-myristoyl transferase	—	OG6 TCSYLVIO_006126 ↔ TCSYLVIO_007000 OG7 TCSYLVIO_006126 ↔ TCSYLVIO_007000	Both
C4B63_44g252 ⚠ ubiquitin carboxyl-terminal hydrolase	—	OG6 TCSYLVIO_002972 ↔ TCSYLVIO_007000 OG7 TCSYLVIO_002972 ↔ TCSYLVIO_007000	Both
C4B63_279g8 ⚠ ubiquitin carboxyl-terminal hydrolase	—	OG6 TCSYLVIO_002972 ↔ TCSYLVIO_007000 OG7 TCSYLVIO_002972 ↔ TCSYLVIO_007000	Both
C4B63_47g80 Gamma-soluble NSF attachment protein	—	OG6 TCSYLVIO_004539 ↔ TCSYLVIO_007000 OG7 TCSYLVIO_004539 ↔ TCSYLVIO_007000	Both
C4B63_19g259 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005459 ↔ TCSYLVIO_007000 OG7 TCSYLVIO_005459 ↔ TCSYLVIO_007000	Both
C4B63_48g23 nicotinate phosphoribosyltransferase	—	OG6 TCSYLVIO_004898 ↔ TCSYLVIO_007000 OG7 TCSYLVIO_004898 ↔ TCSYLVIO_007000	Both
C4B63_112g17 conserved hypothetical protein	—	OG6 TCSYLVIO_001734 ↔ TCSYLVIO_007000 OG7 TCSYLVIO_001734 ↔ TCSYLVIO_007000	Both
C4B63_9g331 ⚠ transcription elongation factor s-II	—	OG6 TCSYLVIO_000382 ↔ TCSYLVIO_007000 OG7 TCSYLVIO_000382 ↔ TCSYLVIO_007000	Both
C4B63_23g248 ⚠ inorganic pyrophosphatase	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_007000 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_007000	Both
C4B63_70g77 ⚠ acidocalcisomal pyrophosphatase	—	OG6 TCSYLVIO_004455 ↔ TCSYLVIO_007000 OG7 TCSYLVIO_004455 ↔ TCSYLVIO_007000	Both
C4B63_225g44 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_007538 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_007538	Both
C4B63_110g27 ⚠ Leucine-rich repeat-containing protein 34	—	OG6 TCSYLVIO_007000 ↔ TCSYLVIO_007538 OG7 TCSYLVIO_007000 ↔ TCSYLVIO_007538	Both

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