C4B63_184g38

TPR-repeat protein
Trypanosoma cruzi Dm28c 2018 OG6: OG6_103410 OG7: OG7_0001150 202 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 202 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_23g207 ⚠
tRNA (cytosine(34)-C(5))-methyltransferase
— OG6
C4B63_22g292 ⚠
deoxyhypusine synthase
— OG6
C4B63_7g79 ⚠
aspartyl-tRNA synthetase
— OG6
C4B63_7g133 ⚠
pyroglutamyl-peptidase I
— OG6
C4B63_81g44 ⚠
tRNA (cytosine(34)-C(5))-methyltransferase
— OG6
C4B63_13g230 ⚠
Eukaryotic translation initiation factor 6
— OG6
C4B63_13g161 ⚠
conserved hypothetical protein
— OG6
C4B63_61g23 ⚠
tRNA-dihydrouridine synthase 3
— OG6
C4B63_47g52 ⚠
deoxyhypusine synthase
— OG6
C4B63_47g53 ⚠
deoxyhypusine synthase
— OG6
C4B63_14g241 ⚠
trypanothione reductase
— OG6
C4B63_10g305 ⚠
conserved hypothetical protein
— OG6
C4B63_397g13 ⚠
protein kinase
— OG6
C4B63_124g7 ⚠
Pre-mRNA-splicing factor 38
— OG6
C4B63_101g36 ⚠
inositol-3-phosphate synthase
— OG6
C4B63_52g161 ⚠
tyrosyl-tRNA synthetase
— OG6
C4B63_25g329 ⚠
Nuclear migration protein nudC
— OG6
C4B63_19g137 ⚠
cleavage and polyadenylation specificity fact
— OG6
C4B63_227g2 ⚠
glucan 1,3-alpha-glucosidase
— OG6
C4B63_14g97 ⚠
isoleucyl-tRNA synthetase
— OG6
C4B63_2g823 ⚠
acyl-CoA dehydrogenase
— OG6
C4B63_21g251 ⚠
conserved hypothetical protein
— OG6
C4B63_2g244 ⚠
conserved hypothetical protein
— OG6
C4B63_10g437 ⚠
U-box domain protein
— OG6
C4B63_14g50 ⚠
disgorgin
— OG6
C4B63_21g261 ⚠
isocitrate dehydrogenase [NADP], mitochondria
— OG6
C4B63_339g3 ⚠
tRNA-dihydrouridine synthase 3
— OG6
C4B63_11g25 ⚠
conserved hypothetical protein
— OG6
C4B63_7g361 ⚠
phosphomannomutase-like protein
— OG6
C4B63_17g188 ⚠
Phosphopantetheine adenylyltransferase
— OG6
C4B63_30g144 ⚠
Cilia- and flagella-associated protein 52
— OG6
C4B63_2g243 ⚠
conserved hypothetical protein
— OG6
C4B63_52g157 ⚠
serine hydroxymethyltransferase
— OG6
C4B63_11g9 ⚠
eukaryotic translation initiation factor 3 su
— OG6
C4B63_19g185 ⚠
isocitrate dehydrogenase
— OG6
C4B63_23g110 ⚠
UDP-glucose:glycoprotein glucosyltransferase
— OG6
C4B63_303g16 ⚠
trypanothione reductase
— OG6
C4B63_79g37 ⚠
methionyl-tRNA synthetase
— OG6
C4B63_149g26 ⚠
GDP-mannose pyrophosphorylase
— OG6
C4B63_93g69 ⚠
tRNA (Uracil-5-)-methyltransferase
— OG6
C4B63_19g179 ⚠
protein kinase
— OG6
C4B63_355g19 ⚠
inositol-3-phosphate synthase(fragment)
— OG6
C4B63_14g96 ⚠
isoleucil-tRNA synthetase
— OG6
C4B63_58g37 ⚠
conserved hypothetical protein
— OG6
C4B63_22g116 ⚠
Pre-mRNA-splicing factor 38
— OG6
C4B63_21g253 ⚠
Mitogen-activated protein kinase 10
— OG6
C4B63_15g7 ⚠
protein kinase
— OG6
C4B63_54g28 ⚠
conserved hypothetical protein
— OG6
C4B63_19g195 ⚠
Nuclear pore complex protein 158
— OG6
C4B63_52g143 ⚠
Bifunctional NAD(P)H-hydrate repair enzyme
— OG6
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.