C4B63_79g37

methionyl-tRNA synthetase

Trypanosoma cruzi Dm28c 2018 OG6: OG6_101119 OG7: OG7_0003306 159 interactions (filtered)

Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used

Source datasets

T.brucei_2016_Gazestani

T.brucei_2017_Crozier

L.donovani_2025_Azimi

T.cruzi_2025_Azimi

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Network view up to 80 partners

Query Computational only Exp + computational Experimental only

Interactions 159 total

Partner	Experimental (Co-frac/MS)	Computational (OG inference)	OG
C4B63_42g178 histidyl-tRNA synthetase	—	OG6 TCSYLVIO_003126 ↔ TCSYLVIO_007991 OG6 Tb927.10.1500 ↔ Tb927.6.2060 OG7 TCSYLVIO_003126 ↔ TCSYLVIO_007991 OG7 Tb927.10.1500 ↔ Tb927.6.2060	Both
C4B63_425g4 ⚠ tyrosyl or methionyl-tRNA synthetase	—	OG6 Tb927.10.1500 ↔ Tb927.7.2400 OG6 TCSYLVIO_001244 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_007991 OG7 Tb927.10.1500 ↔ Tb927.7.3620 +2 more	Both
C4B63_18g212 valyl-tRNA synthetase	—	OG6 Tb927.10.1500 ↔ Tb927.6.4480 OG6 TCSYLVIO_003345 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_003345 ↔ TCSYLVIO_007991 OG7 Tb927.10.1500 ↔ Tb927.6.4480	Both
C4B63_52g161 ⚠ tyrosyl-tRNA synthetase	—	OG6 Tb927.10.1500 ↔ Tb927.7.3620 OG6 TCSYLVIO_007991 ↔ TCSYLVIO_010624 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_007991 OG7 Tb927.10.1500 ↔ Tb927.7.3620 +2 more	Both
C4B63_76g56 ⚠ Aminoacyl tRNA synthase complex-interacting m	—	OG6 Tb927.10.1500 ↔ Tb927.7.2400 OG6 TCSYLVIO_001244 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_007991 OG7 Tb927.10.1500 ↔ Tb927.7.3620 +2 more	Both
C4B63_55g95 ⚠ tyrosyl or methionyl-tRNA synthetase	—	OG6 Tb927.10.1500 ↔ Tb927.7.2400 OG6 TCSYLVIO_001244 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_001244 ↔ TCSYLVIO_007991 OG7 Tb927.10.1500 ↔ Tb927.7.3620 +2 more	Both
C4B63_46g91 leucyl-tRNA synthetase	—	OG6 Tb927.10.1500 ↔ Tb927.11.3730 OG6 TCSYLVIO_003028 ↔ TCSYLVIO_007991 OG7 Tb927.10.1500 ↔ Tb927.11.3730 OG7 TCSYLVIO_003028 ↔ TCSYLVIO_007991	Both
C4B63_70g572c ⚠ cytochrome b5	—	OG7 TCSYLVIO_003124 ↔ TCSYLVIO_007991	OG7
C4B63_147g73 ⚠ U3 snoRNP-associated protein-like YAOH	—	OG6 TCSYLVIO_005180 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_005180 ↔ TCSYLVIO_007991	Both
C4B63_147g74 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_005180 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_005180 ↔ TCSYLVIO_007991	Both
C4B63_49g81 ⚠ translation initiation factor IF-2	—	OG6 TCSYLVIO_001768 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_001768 ↔ TCSYLVIO_007991	Both
C4B63_11g9 eukaryotic translation initiation factor 3 su	—	OG6 TCSYLVIO_006404 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_006404 ↔ TCSYLVIO_007991	Both
C4B63_227g2 ⚠ glucan 1,3-alpha-glucosidase	—	OG6 TCSYLVIO_006140 ↔ TCSYLVIO_007991 OG6 TCSYLVIO_006141 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_007991	Both
C4B63_4g375 ⚠ glucan 1,3-alpha-glucosidase	—	OG6 TCSYLVIO_006140 ↔ TCSYLVIO_007991 OG6 TCSYLVIO_006141 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_006140 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_006141 ↔ TCSYLVIO_007991	Both
C4B63_23g207 ⚠ tRNA (cytosine(34)-C(5))-methyltransferase	—	OG6 TCSYLVIO_004998 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_004998 ↔ TCSYLVIO_007991	Both
C4B63_81g44 ⚠ tRNA (cytosine(34)-C(5))-methyltransferase	—	OG6 TCSYLVIO_004998 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_004998 ↔ TCSYLVIO_007991	Both
C4B63_54g28 conserved hypothetical protein	—	OG6 TCSYLVIO_005084 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_005084 ↔ TCSYLVIO_007991	Both
C4B63_184g38 ⚠ TPR-repeat protein	—	OG6 TCSYLVIO_003496 ↔ TCSYLVIO_007991	OG6
C4B63_13g167 ⚠ stress-inducible protein STI1-like	—	OG6 TCSYLVIO_003496 ↔ TCSYLVIO_007991	OG6
C4B63_175g8 ⚠ TPR-repeat protein	—	OG6 TCSYLVIO_003496 ↔ TCSYLVIO_007991	OG6
C4B63_23g110 ⚠ UDP-glucose:glycoprotein glucosyltransferase	—	OG6 TCSYLVIO_004363 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_004363 ↔ TCSYLVIO_007991	Both
C4B63_23g109 ⚠ UDP-glucose:glycoprotein glucosyltransferase	—	OG6 TCSYLVIO_004363 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_004363 ↔ TCSYLVIO_007991	Both
C4B63_19g137 ⚠ cleavage and polyadenylation specificity fact	—	OG6 TCSYLVIO_005414 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_005414 ↔ TCSYLVIO_007991	Both
C4B63_49g164 ⚠ alanyl-tRNA synthetase	—	OG6 TCSYLVIO_001889 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_001889 ↔ TCSYLVIO_007991	Both
C4B63_49g165 ⚠ alanyl-tRNA synthetase	—	OG6 TCSYLVIO_001889 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_001889 ↔ TCSYLVIO_007991	Both
C4B63_49g166 ⚠ alanyl-tRNA synthetase	—	OG6 TCSYLVIO_001889 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_001889 ↔ TCSYLVIO_007991	Both
C4B63_6g521 ⚠ DIS3-like exonuclease	—	OG6 TCSYLVIO_002525 ↔ TCSYLVIO_007991 OG6 TCSYLVIO_002526 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007991	Both
C4B63_109g37 ⚠ Gar1/Naf1 RNA binding region containing prote	—	OG6 TCSYLVIO_000836 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_007991	Both
C4B63_34g118 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_000836 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_000836 ↔ TCSYLVIO_007991	Both
C4B63_56g84 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001973 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_007991	Both
C4B63_56g85 ⚠ conserved hypothetical protein	—	OG6 TCSYLVIO_001973 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_001973 ↔ TCSYLVIO_007991	Both
C4B63_14g97 ⚠ isoleucyl-tRNA synthetase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007991	Both
C4B63_14g96 ⚠ isoleucil-tRNA synthetase	—	OG6 TCSYLVIO_004705 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_004705 ↔ TCSYLVIO_007991	Both
C4B63_102g61 ⚠ aspartyl-tRNA synthetase	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007991	Both
C4B63_42g202 ⚠ aspartyl-tRNA synthetase	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007991	Both
C4B63_42g203 ⚠ aspartyl-tRNA synthetase	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007991	Both
C4B63_168g16 ⚠ aspartyl-tRNA synthetase	—	OG6 TCSYLVIO_003107 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_003107 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_003867 ↔ TCSYLVIO_007991	Both
C4B63_23g248 ⚠ inorganic pyrophosphatase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007991	Both
C4B63_70g77 ⚠ acidocalcisomal pyrophosphatase	—	OG6 TCSYLVIO_001709 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_001709 ↔ TCSYLVIO_007991	Both
C4B63_42g42 co-chaperone GrpE	—	OG6 TCSYLVIO_003139 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_003139 ↔ TCSYLVIO_007991	Both
C4B63_149g26 GDP-mannose pyrophosphorylase	—	OG6 TCSYLVIO_007603 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_007603 ↔ TCSYLVIO_007991	Both
C4B63_30g129 ⚠ rrp44p homologue	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007991	OG7
C4B63_193g9 ⚠ metallo-peptidase, Clan MF, Family M17	—	OG7 TCSYLVIO_005560 ↔ TCSYLVIO_007991	OG7
C4B63_276g11 ⚠ DIS3-like exonuclease(fragment)	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007991	OG7
C4B63_72g106 ⚠ DIS3-like exonuclease(fragment)	—	OG7 TCSYLVIO_002525 ↔ TCSYLVIO_007991 OG7 TCSYLVIO_002526 ↔ TCSYLVIO_007991	OG7
C4B63_20g51 ⚠ tRNA-dihydrouridine synthase 4	—	OG7 TCSYLVIO_007991 ↔ TCSYLVIO_009102	OG7
C4B63_313g3 ⚠ dihydrouridine synthase (Dus)(fragment)	—	OG7 TCSYLVIO_007991 ↔ TCSYLVIO_009102	OG7
C4B63_336g10 ⚠ dihydrouridine synthase (Dus)	—	OG7 TCSYLVIO_007991 ↔ TCSYLVIO_009102	OG7
C4B63_350g11 ⚠ dihydrouridine synthase (Dus)	—	OG7 TCSYLVIO_007991 ↔ TCSYLVIO_009102	OG7
C4B63_13g118 ⚠ tRNA-dihydrouridine synthase 2	—	OG7 TCSYLVIO_007991 ↔ TCSYLVIO_009102	OG7

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