C4B63_42g42

co-chaperone GrpE
Trypanosoma cruzi Dm28c 2018 OG6: OG6_100642 OG7: OG7_0004892 157 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 157 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_18g260
small glutamine-rich tetratricopeptide repeat
— OG6
C4B63_42g593c ⚠
small nuclear ribonucleoprotein Sm-E
— OG7
C4B63_72g106 ⚠
DIS3-like exonuclease(fragment)
— OG7
C4B63_8g54
conserved hypothetical protein
— OG7
C4B63_7g388 ⚠
geranylgeranyl transferase type II beta subun
— OG7
C4B63_50g5 ⚠
protein farnesyltransferase
— OG7
C4B63_8g219 ⚠
protein farnesyltransferase
— OG7
C4B63_6g517 ⚠
geranylgeranyl transferase type II beta subun
— OG7
C4B63_22g108 ⚠
Replication Factor C Subunit 1-related protei
— OG7
C4B63_4g258
prolyl-tRNA synthetase
— OG7
C4B63_2g762 ⚠
replication factor C, subunit 3
— OG7
C4B63_61g82 ⚠
Chromosome transmission fidelity protein 18 h
— OG7
C4B63_28g129 ⚠
replication factor C, subunit 1
— OG7
C4B63_18g277 ⚠
replication factor C, subunit 2
— OG7
C4B63_61g81 ⚠
conserved hypothetical protein
— OG7
C4B63_63g41 ⚠
replication factor C, subunit 3
— OG7
C4B63_39g340 ⚠
replication factor C, subunit 4
— OG7
C4B63_2g376 ⚠
ribosome assembly protein RRB1
— OG7
C4B63_271g10 ⚠
conserved hypothetical protein
— OG7
C4B63_14g171 ⚠
ubiquitin-protein ligase
— OG7
C4B63_2g815 ⚠
conserved hypothetical protein
— OG7
C4B63_17g98 ⚠
E3 ubiquitin-protein ligase UPL3
— OG7
C4B63_2g817 ⚠
conserved hypothetical protein
— OG7
C4B63_2g297
conserved hypothetical protein
— OG7
C4B63_49g54 ⚠
p22 protein precursor (Mitochondrial glycopro
— OG7
C4B63_69g26
endo-beta-N-acetylglucosaminidase
— OG7
C4B63_43g202 ⚠
hook complex protein, conserved
— OG7
C4B63_2g816 ⚠
conserved hypothetical protein
— OG7
C4B63_56g82 ⚠
mitochondrial glycoprotein-like protein
— OG7
C4B63_7g382 ⚠
ubiquitin-protein ligase
— OG7
C4B63_2g88 ⚠
ubiquitin-protein ligase
— OG7
C4B63_84g82
DNA mismatch repair protein MSH2
— OG7
C4B63_54g82
conserved hypothetical protein
— OG7
C4B63_293g2 ⚠
p22 protein precursor (Mitochondrial glycopro
— OG7
C4B63_2g768
RNA-binding protein
— OG7
C4B63_4g269
conserved hypothetical protein
— OG7
C4B63_8g190 ⚠
conserved hypothetical protein
— OG7
C4B63_197g36 ⚠
conserved hypothetical protein
— OG7
C4B63_52g161 ⚠
tyrosyl-tRNA synthetase
— OG7
C4B63_76g32
guide RNA associated protein, GAP2
— OG7
C4B63_17g265 ⚠
Probable ADP-ribosylation factor GTPase-activ
— OG7
C4B63_10g489 ⚠
ADP-ribosylation factor GTPase activating pro
— OG7
C4B63_6g417 ⚠
ADP-ribosylation factor GTPase activating pro
— OG7
C4B63_70g129 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_193g9 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_25g215 ⚠
tRNA (cytosine(34)-C(5))-methyltransferase
— OG7
C4B63_26g231 ⚠
ubiquitin hydrolase(fragment)
— OG7
C4B63_4g245 ⚠
Multisite-specific tRNA:(cytosine-C(5))-methy
— OG7
C4B63_12g153 ⚠
metallo-peptidase, Clan MF, Family M17
— OG7
C4B63_75g70 ⚠
ADP-ribosylation factor GTPase activating pro
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.