C4B63_14g171

ubiquitin-protein ligase
Trypanosoma cruzi Dm28c 2018 OG6: OG6_158309 OG7: OG7_0002947 170 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 170 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_31g99 ⚠
WD repeat-containing protein 17
— OG7
C4B63_134g73 ⚠
conserved hypothetical protein
— OG7
C4B63_134g72 ⚠
XRN 5'-3' exonuclease N-terminus
— OG7
C4B63_31g273 ⚠
XRN 5'-3' exonuclease N-terminus
— OG7
C4B63_4g1058c ⚠
sporangia induced deflagellation-inducible pr
— OG7
C4B63_227g70c ⚠
sjogren s syndrome nuclear autoantigen 1
— OG7
C4B63_128g63 ⚠
GTP-binding protein
— OG7
C4B63_56g32 ⚠
GTPase
— OG7
C4B63_8g202 ⚠
GTP-binding protein
— OG7
C4B63_91g35 ⚠
GTPase
— OG7
C4B63_2g345 ⚠
GTP-binding protein
— OG7
C4B63_128g62 ⚠
50S ribosome-binding GTPase
— OG7
C4B63_128g61 ⚠
50S ribosome-binding GTPase
— OG7
C4B63_2g431 ⚠
GTPase protein
— OG7
C4B63_76g32 ⚠
guide RNA associated protein, GAP2
— OG7
C4B63_56g50 ⚠
Surp module,
— OG7
C4B63_56g51 ⚠
RNA-binding protein
— OG7
C4B63_31g76 ⚠
ubiquitin-activating enzyme
— OG7
C4B63_42g593c ⚠
small nuclear ribonucleoprotein Sm-E
— OG7
C4B63_85g75 ⚠
ubiquitin activating enzyme
— OG7
C4B63_69g174c ⚠
U6 snRNA-associated Sm-like protein LSm6p
— OG7
C4B63_144g102c ⚠
U6 snRNA-associated Sm-like protein LSm6p
— OG7
C4B63_271g80c ⚠
U6 snRNA-associated Sm-like protein LSm7p
— OG7
C4B63_43g1065c ⚠
U6 snRNA-associated Sm-like protein LSm7p
— OG7
C4B63_11g283c ⚠
U6 snRNA-associated Sm-like protein LSm8
— OG7
C4B63_2g1123c ⚠
small nuclear ribonucleoprotein Sm-F
— OG7
C4B63_26g232 ⚠
ubiquitin hydrolase(fragment)
— OG7
C4B63_2g4 ⚠
ubiquitin hydrolase
— OG7
C4B63_7g391 ⚠
ubiquitin hydrolase
— OG7
C4B63_26g231 ⚠
ubiquitin hydrolase(fragment)
— OG7
C4B63_7g392 ⚠
ubiquitin hydrolase
— OG7
C4B63_233g32 ⚠
ubiquitin hydrolase
— OG7
C4B63_233g31 ⚠
ubiquitin hydrolase
— OG7
C4B63_6g411 ⚠
Replication factor A 51 kDa subunit
— OG7
C4B63_6g389 ⚠
D123
— OG7
C4B63_4g320 ⚠
conserved hypothetical protein
— OG7
C4B63_20g61 ⚠
conserved hypothetical protein
— OG7
C4B63_26g261 ⚠
glutamate dehydrogenase
— OG7
C4B63_295g26 ⚠
glutamate dehydrogenase
— OG7
C4B63_7g229 ⚠
Probable 18S rRNA (guanine-N(7))-methyltransf
— OG7
C4B63_102g53 ⚠
conserved hypothetical protein
— OG7
C4B63_18g147 ⚠
calmodulin
— OG7
C4B63_75g61 ⚠
calmodulin
— OG7
C4B63_42g192 ⚠
N-alpha-acetyltransferase 25, NatB auxiliary
— OG7
C4B63_113g58 ⚠
hydrogenase
— OG7
C4B63_8g510 ⚠
conserved hypothetical protein
— OG7
C4B63_82g92 ⚠
conserved hypothetical protein
— OG7
C4B63_77g26 ⚠
conserved hypothetical protein
— OG7
C4B63_22g79 ⚠
Tubulin/FtsZ family
— OG7
C4B63_84g82 ⚠
DNA mismatch repair protein MSH2
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.