C4B63_6g389

D123
Trypanosoma cruzi Dm28c 2018 OG6: OG6_146486 OG7: OG7_0042742 115 interactions (filtered)
Experimental Direct co-fractionation MS evidence Computational Inferred by orthology (OG) transfer ⚠ Ambiguous: multiple orthologs in target organism OG6 / OG7 Ortholog group version used
Source datasets
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Interactions 115 total
Partner Experimental (Co-frac/MS) Computational (OG inference) OG
C4B63_31g273 ⚠
XRN 5'-3' exonuclease N-terminus
— OG7
C4B63_79g85 ⚠
nucleotide-binding protein
— Both
C4B63_8g526 ⚠
nucleotide-binding protein
— Both
C4B63_330g2 ⚠
MRP protein
— OG6
C4B63_19g44 ⚠
5'-3' exoribonuclease 2
— Both
C4B63_34g313
casein kinase II, alpha chain
— OG6
C4B63_168g23 ⚠
Programmed cell death protein 2, C-terminal d
— Both
C4B63_6g411
Replication factor A 51 kDa subunit
— Both
C4B63_16g122 ⚠
Beta-lactamase superfamily domain containing
— Both
C4B63_102g71 ⚠
Programmed cell death protein 2, C-terminal d
— Both
C4B63_49g131 ⚠
conserved hypothetical protein
— Both
C4B63_49g130 ⚠
Putative hydrolase C777.06c
— Both
C4B63_113g58
hydrogenase
— Both
C4B63_21g114 ⚠
oxidoreductase
— OG7
C4B63_199g21 ⚠
oxidoreductase
— OG7
C4B63_13g152 ⚠
elongation factor 2
— OG7
C4B63_13g157 ⚠
elongation factor 2
— OG7
C4B63_13g153 ⚠
elongation factor 2
— OG7
C4B63_13g156 ⚠
elongation factor 2
— OG7
C4B63_9g523 ⚠
U5 small nuclear ribonucleoprotein component
— OG7
C4B63_13g155 ⚠
elongation factor 2
— OG7
C4B63_13g154 ⚠
elongation factor 2
— OG7
C4B63_24g224
conserved hypothetical protein
— OG7
C4B63_21g280
ribonuclease mar1
— OG7
C4B63_35g166 ⚠
XRN 5'-3' exonuclease N-terminus
— OG7
C4B63_134g71 ⚠
conserved hypothetical protein
— OG7
C4B63_60g125 ⚠
XRN 5'-3' exonuclease N-terminus
— OG7
C4B63_134g73 ⚠
conserved hypothetical protein
— OG7
C4B63_134g72 ⚠
XRN 5'-3' exonuclease N-terminus
— OG7
C4B63_17g98 ⚠
E3 ubiquitin-protein ligase UPL3
— OG7
C4B63_19g271
conserved hypothetical protein
— OG7
C4B63_263g16 ⚠
Programmed cell death protein 2-like
— OG7
C4B63_7g324 ⚠
Programmed cell death protein 2, C-terminal d
— OG7
C4B63_7g323 ⚠
conserved hypothetical protein
— OG7
C4B63_10g137
conserved hypothetical protein
— OG7
C4B63_233g31 ⚠
ubiquitin hydrolase
— OG7
C4B63_233g32 ⚠
ubiquitin hydrolase
— OG7
C4B63_13g118 ⚠
tRNA-dihydrouridine synthase 2
— OG7
C4B63_20g51 ⚠
tRNA-dihydrouridine synthase 4
— OG7
C4B63_293g2 ⚠
p22 protein precursor (Mitochondrial glycopro
— OG7
C4B63_7g382 ⚠
ubiquitin-protein ligase
— OG7
C4B63_56g82 ⚠
mitochondrial glycoprotein-like protein
— OG7
C4B63_339g3 ⚠
tRNA-dihydrouridine synthase 3
— OG7
C4B63_49g54 ⚠
p22 protein precursor (Mitochondrial glycopro
— OG7
C4B63_91g35 ⚠
GTPase
— OG7
C4B63_40g50 ⚠
metallo-peptidase, Clan MC, Family M14
— OG7
C4B63_2g431 ⚠
GTPase protein
— OG7
C4B63_2g345 ⚠
GTP-binding protein
— OG7
C4B63_26g232 ⚠
ubiquitin hydrolase(fragment)
— OG7
C4B63_8g202 ⚠
GTP-binding protein
— OG7
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Orthogroup expansion — connections between the query proteins
list 30/60/…
How many partner orthogroups appear in the table below. It does not change the analysis — the counts in the summary line always cover all partners.
degree ≤ N
Drops partners that interact with more than N orthogroups across the whole network. Promiscuous hubs connect to everything and explain nothing: the top partner of this query set by raw degree is a retrotransposon hot spot protein touching 586 orthogroups.
Score
(queries touched + 2 if bridge + 0.5 if other-network) ÷ log2(2 + degree). Rewards partners that connect the query set; penalises promiscuity.
Queries
How many of the query proteins' orthogroups this partner interacts with. 2 or more makes it a shared partner.
bridge
It links query proteins that came from different organisms.
other network
At least one of its links is supported only by a dataset from an organism other than that query protein's own — invisible in the network being searched. This is the discovery signal.
complex N
The partner belongs to conserved complex N (two or more datasets).
hub
Degree above 150 — interpret with care.
Click Analyse to look for partners that link the query proteins through the orthogroup network, including links only visible in another organism's dataset.